Protein Alignment Hsc70-2 and Hspa2

DIOPT Version :9

• Sequence 1: NP_524339.1
• Gene: Hsc70-2 / 41609
• FlyBaseID: FBgn0001217
• Length: 633
• Species: Drosophila melanogaster
• Sequence 2: NP_001002012.1
• Gene: Hspa2 / 15512
• MGIID: 96243
• Length: 633
• Species: Mus musculus
• Alignment Length: 631
• Identity: 455/631 - (72%)
• Similarity: 535/631 - (84%)
• Gaps: 6/631 - (0%)

  Fly     5 PAIGIDLGTTYSCVGVWQNSKVEIIANDQGNRTTPSYVAFNETERLIGDPAKNQVAMNAKNTVFD 69
            ||||||||||||||||:|:.||||||||||||||||||||.:|||||||.||||||||..||:||
Mouse     6 PAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNTIFD 70

  Fly    70 AKRLIGRKFDDKKIQEDLKLWPFKVINEKGKPKIEVEFKGERKRFAPEEISSMVLTKMREIAEVY 134
            |||||||||:|..:|.|:|.|||:|::|.||||::||:|||.|.|.||||||||||||:||||.|
Mouse    71 AKRLIGRKFEDATVQSDMKHWPFRVVSEGGKPKVQVEYKGEMKTFFPEEISSMVLTKMKEIAEAY 135

  Fly   135 LGGKVKDAVVTVPAYFNDSQRQATKDAGSIAGLNVLRIINEPTAAALAYGLDKN--LKGERNVLI 197
            |||||:.||:||||||||||||||||||:|.|||||||||||||||:||||||.  ..||:||||
Mouse   136 LGGKVQSAVITVPAYFNDSQRQATKDAGTITGLNVLRIINEPTAAAIAYGLDKKGCAGGEKNVLI 200

  Fly   198 FDLGGGTFDVSVLSIDEGSLFEVKATAGDTHLGGEDFDNRLVNHFAEEFKRKHKSDIKGNARALR 262
            |||||||||||:|:|::| :||||:|||||||||||||||:|:|.|||||||||.||..|.||:|
Mouse   201 FDLGGGTFDVSILTIEDG-IFEVKSTAGDTHLGGEDFDNRMVSHLAEEFKRKHKKDIGPNKRAVR 264

  Fly   263 RLRTACERAKRTLSSSTEASLEIDALHEGIDFYSKISRARFEELNMDLFRSTMQPVERALSDAKM 327
            |||||||||||||||||:||:|||:|:||:|||:.|:||||||||.||||.|::|||:||.|||:
Mouse   265 RLRTACERAKRTLSSSTQASIEIDSLYEGVDFYTSITRARFEELNADLFRGTLEPVEKALRDAKL 329

  Fly   328 DKKAIHDVVLVGGSTRIPKIQKLLQDLFGGKQLNLSINPDEAVAYGAAVQAAILTGVGSSQIQDL 392
            ||..|.::||||||||||||||||||.|.||:||.|||||||||||||||||||.|..|..:|||
Mouse   330 DKGQIQEIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILIGDKSENVQDL 394

  Fly   393 LLVDVAPLSLGIETAGGVMTNLVERNARIPCKQQQIFTTYSDNQNAVTIQVYEGERAMTKDNNLL 457
            ||:||.||||||||||||||.|::||..||.||.|.||||||||::|.:||||||||||||||||
Mouse   395 LLLDVTPLSLGIETAGGVMTPLIKRNTTIPTKQTQTFTTYSDNQSSVLVQVYEGERAMTKDNNLL 459

  Fly   458 GTFNLTGIPPAPRGVPQIEVAFDLNADGILNVNAKDNSTGKSEKITISNDKGRLSKAEIDRMLSE 522
            |.|:||||||||||||||||.||::|:|||||.|.|.||||..||||:||||||||.:||||:.|
Mouse   460 GKFDLTGIPPAPRGVPQIEVTFDIDANGILNVTAADKSTGKENKITITNDKGRLSKDDIDRMVQE 524

  Fly   523 AEKYKVEDDRQRERVQSKNNLEAYIYACRQAVDDAP-SGVLSETERSKVRDKCSSEASWLDKNSL 586
            ||:||.||:..|:||.:||.:|:|.|..:|.|:|.. .|.:||.:::|:.|||....:|||:|.:
Mouse   525 AERYKSEDEANRDRVAAKNAVESYTYNIKQTVEDEKLRGKISEQDKNKILDKCQEVINWLDRNQM 589

  Fly   587 AEKEEFESHLKECQRICTPIMSKIHGGKKGKSSMGKGSHPTVEEVD 632
            |||:|:|...||.:|:|.||:||::.|  |....|....||:||||
Mouse   590 AEKDEYEHKQKELERVCNPIISKLYQG--GPGGGGSSGGPTIEEVD 633

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-2	NP_524339.1	PTZ00009	1..632	CDD:240227	453/629 (72%)
		HSPA1-2_6-8-like_NBD	6..382	CDD:212675	298/377 (79%)
Hspa2	NP_001002012.1	PTZ00009	2..615	CDD:240227	446/609 (73%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142	2..389		301/383 (79%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142	397..512		88/114 (77%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	613..633		7/21 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53894
OrthoDB	1	1.010	-	-		D180577at33208
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.730