DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hsc70-2 and Hspa8

DIOPT Version :9

Sequence 1:NP_524339.1 Gene:Hsc70-2 / 41609 FlyBaseID:FBgn0001217 Length:633 Species:Drosophila melanogaster
Sequence 2:NP_112442.2 Gene:Hspa8 / 15481 MGIID:105384 Length:646 Species:Mus musculus


Alignment Length:647 Identity:462/647 - (71%)
Similarity:537/647 - (82%) Gaps:16/647 - (2%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MGKIPAIGIDLGTTYSCVGVWQNSKVEIIANDQGNRTTPSYVAFNETERLIGDPAKNQVAMNAKN 65
            |.|.||:|||||||||||||:|:.||||||||||||||||||||.:|||||||.||||||||..|
Mouse     1 MSKGPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTN 65

  Fly    66 TVFDAKRLIGRKFDDKKIQEDLKLWPFKVINEKGKPKIEVEFKGERKRFAPEEISSMVLTKMREI 130
            |||||||||||:|||..:|.|:|.|||.|:|:.|:||::||:|||.|.|.|||:||||||||:||
Mouse    66 TVFDAKRLIGRRFDDAVVQSDMKHWPFMVVNDAGRPKVQVEYKGETKSFYPEEVSSMVLTKMKEI 130

  Fly   131 AEVYLGGKVKDAVVTVPAYFNDSQRQATKDAGSIAGLNVLRIINEPTAAALAYGLDKNLKGERNV 195
            ||.|||..|.:|||||||||||||||||||||:|||||||||||||||||:||||||.:..||||
Mouse   131 AEAYLGKTVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKKVGAERNV 195

  Fly   196 LIFDLGGGTFDVSVLSIDEGSLFEVKATAGDTHLGGEDFDNRLVNHFAEEFKRKHKSDIKGNARA 260
            |||||||||||||:|:|::| :||||:|||||||||||||||:||||..|||||||.||..|.||
Mouse   196 LIFDLGGGTFDVSILTIEDG-IFEVKSTAGDTHLGGEDFDNRMVNHFIAEFKRKHKKDISENKRA 259

  Fly   261 LRRLRTACERAKRTLSSSTEASLEIDALHEGIDFYSKISRARFEELNMDLFRSTMQPVERALSDA 325
            :||||||||||||||||||:||:|||:|:||||||:.|:||||||||.||||.|:.|||:||.||
Mouse   260 VRRLRTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRARFEELNADLFRGTLDPVEKALRDA 324

  Fly   326 KMDKKAIHDVVLVGGSTRIPKIQKLLQDLFGGKQLNLSINPDEAVAYGAAVQAAILTGVGSSQIQ 390
            |:||..|||:||||||||||||||||||.|.||:||.|||||||||||||||||||:|..|..:|
Mouse   325 KLDKSQIHDIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILSGDKSENVQ 389

  Fly   391 DLLLVDVAPLSLGIETAGGVMTNLVERNARIPCKQQQIFTTYSDNQNAVTIQVYEGERAMTKDNN 455
            ||||:||.||||||||||||||.|::||..||.||.|.||||||||..|.|||||||||||||||
Mouse   390 DLLLLDVTPLSLGIETAGGVMTVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNN 454

  Fly   456 LLGTFNLTGIPPAPRGVPQIEVAFDLNADGILNVNAKDNSTGKSEKITISNDKGRLSKAEIDRML 520
            |||.|.||||||||||||||||.||::|:|||||:|.|.||||..||||:||||||||.:|:||:
Mouse   455 LLGKFELTGIPPAPRGVPQIEVTFDIDANGILNVSAVDKSTGKENKITITNDKGRLSKEDIERMV 519

  Fly   521 SEAEKYKVEDDRQRERVQSKNNLEAYIYACRQAVDDAP-SGVLSETERSKVRDKCSSEASWLDKN 584
            .||||||.||::||::|.|||:||:|.:..:..|:|.. .|.:::.::.|:.|||:...||||||
Mouse   520 QEAEKYKAEDEKQRDKVSSKNSLESYAFNMKATVEDEKLQGKINDEDKQKILDKCNEIISWLDKN 584

  Fly   585 SLAEKEEFESHLKECQRICTPIMSKIH-------GGKKG-------KSSMGKGSHPTVEEVD 632
            ..|||||||...||.:::|.||::|::       ||..|       ..|.|..|.||:||||
Mouse   585 QTAEKEEFEHQQKELEKVCNPIITKLYQSAGGMPGGMPGGFPGGGAPPSGGASSGPTIEEVD 646

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hsc70-2NP_524339.1 PTZ00009 1..632 CDD:240227 460/645 (71%)
HSPA1-2_6-8-like_NBD 6..382 CDD:212675 299/375 (80%)
Hspa8NP_112442.2 PTZ00009 1..613 CDD:240227 450/612 (74%)
Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142 2..386 303/384 (79%)
Interaction with BAG1. /evidence=ECO:0000250 186..377 151/191 (79%)
Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142 394..509 89/114 (78%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 614..646 10/31 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0443
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53894
OrthoDB 1 1.010 - - D288077at2759
OrthoFinder 1 1.000 - - FOG0000049
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100083
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
65.730

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