DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hsc70-2 and Hspa5

DIOPT Version :10

Sequence 1:NP_524339.1 Gene:Hsc70-2 / 41609 FlyBaseID:FBgn0001217 Length:633 Species:Drosophila melanogaster
Sequence 2:NP_071705.3 Gene:Hspa5 / 14828 MGIID:95835 Length:655 Species:Mus musculus


Alignment Length:628 Identity:367/628 - (58%)
Similarity:477/628 - (75%) Gaps:16/628 - (2%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 IGIDLGTTYSCVGVWQNSKVEIIANDQGNRTTPSYVAFN-ETERLIGDPAKNQVAMNAKNTVFDA 70
            :|||||||||||||::|.:|||||||||||.|||||||. |.||||||.||||:..|.:||||||
Mouse    32 VGIDLGTTYSCVGVFKNGRVEIIANDQGNRITPSYVAFTPEGERLIGDAAKNQLTSNPENTVFDA 96

  Fly    71 KRLIGRKFDDKKIQEDLKLWPFKVINEKGKPKIEVEF-KGERKRFAPEEISSMVLTKMREIAEVY 134
            ||||||.::|..:|:|:|..||||:.:|.||.|:|:. .|:.|.|||||||:||||||:|.||.|
Mouse    97 KRLIGRTWNDPSVQQDIKFLPFKVVEKKTKPYIQVDIGGGQTKTFAPEEISAMVLTKMKETAEAY 161

  Fly   135 LGGKVKDAVVTVPAYFNDSQRQATKDAGSIAGLNVLRIINEPTAAALAYGLDKNLKGERNVLIFD 199
            ||.||..|||||||||||:|||||||||:||||||:||||||||||:||||||. :||:|:|:||
Mouse   162 LGKKVTHAVVTVPAYFNDAQRQATKDAGTIAGLNVMRIINEPTAAAIAYGLDKR-EGEKNILVFD 225

  Fly   200 LGGGTFDVSVLSIDEGSLFEVKATAGDTHLGGEDFDNRLVNHFAEEFKRKHKSDIKGNARALRRL 264
            |||||||||:|:||.| :|||.||.|||||||||||.|::.||.:.:|:|...|::.:.||:::|
Mouse   226 LGGGTFDVSLLTIDNG-VFEVVATNGDTHLGGEDFDQRVMEHFIKLYKKKTGKDVRKDNRAVQKL 289

  Fly   265 RTACERAKRTLSSSTEASLEIDALHEGIDFYSKISRARFEELNMDLFRSTMQPVERALSDAKMDK 329
            |...|:|||.|||..:|.:||::..||.||...::||:|||||||||||||:||::.|.|:.:.|
Mouse   290 RREVEKAKRALSSQHQARIEIESFFEGEDFSETLTRAKFEELNMDLFRSTMKPVQKVLEDSDLKK 354

  Fly   330 KAIHDVVLVGGSTRIPKIQKLLQDLFGGKQLNLSINPDEAVAYGAAVQAAILTGVGSSQIQDLLL 394
            ..|.::|||||||||||||:|:::.|.||:.:..|||||||||||||||.:|:  |.....||:|
Mouse   355 SDIDEIVLVGGSTRIPKIQQLVKEFFNGKEPSRGINPDEAVAYGAAVQAGVLS--GDQDTGDLVL 417

  Fly   395 VDVAPLSLGIETAGGVMTNLVERNARIPCKQQQIFTTYSDNQNAVTIQVYEGERAMTKDNNLLGT 459
            :||.||:|||||.|||||.|:.||..:|.|:.|||:|.||||..|||:||||||.:||||:||||
Mouse   418 LDVCPLTLGIETVGGVMTKLIPRNTVVPTKKSQIFSTASDNQPTVTIKVYEGERPLTKDNHLLGT 482

  Fly   460 FNLTGIPPAPRGVPQIEVAFDLNADGILNVNAKDNSTGKSEKITISNDKGRLSKAEIDRMLSEAE 524
            |:||||||||||||||||.|:::.:|||.|.|:|..||...||||:||:.||:..||:||:::||
Mouse   483 FDLTGIPPAPRGVPQIEVTFEIDVNGILRVTAEDKGTGNKNKITITNDQNRLTPEEIERMVNDAE 547

  Fly   525 KYKVEDDRQRERVQSKNNLEAYIYACRQAVDDAP--SGVLSETERSKVRDKCSSEASWLDKNSLA 587
            |:..||.:.:||:.::|.||:|.|:.:..:.|..  .|.||..::..:......:..||:.:..|
Mouse   548 KFAEEDKKLKERIDTRNELESYAYSLKNQIGDKEKLGGKLSSEDKETMEKAVEEKIEWLESHQDA 612

  Fly   588 EKEEFESHLKECQRICTPIMSKIHGGKKGKSSMGKGSHPTVEE 630
            :.|:|::..||.:.|..||:||::|        ..|..||.||
Mouse   613 DIEDFKAKKKELEEIVQPIISKLYG--------SGGPPPTGEE 647

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hsc70-2NP_524339.1 PTZ00009 1..632 CDD:240227 367/628 (58%)
Hspa5NP_071705.3 Required for interaction with ELAPOR1. /evidence=ECO:0000250|UniProtKB:P11021 1..81 39/48 (81%)
HSP70 31..636 CDD:394970 361/607 (59%)
Nucleotide-binding (NBD). /evidence=ECO:0000250|UniProtKB:P11021 126..281 110/156 (71%)
Interdomain linker. /evidence=ECO:0000250|UniProtKB:G3I8R9 410..420 3/9 (33%)
Substrate-binding (SBD). /evidence=ECO:0000250|UniProtKB:P11021 421..501 58/79 (73%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 632..655 8/24 (33%)
Prevents secretion from ER 652..655
Blue background indicates that the domain is not in the aligned region.

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