Protein Alignment Hsc70-2 and Grp170

DIOPT Version :10

• Sequence 1: NP_524339.1
• Gene: Hsc70-2 / 41609
• FlyBaseID: FBgn0001217
• Length: 633
• Species: Drosophila melanogaster
• Sequence 2: XP_321225.4
• Gene: Grp170 / 1281282
• VectorBaseID: AGAMI1_004700
• Length: 975
• Species: Anopheles gambiae
• Alignment Length: 782
• Identity: 182/782 - (23%)
• Similarity: 311/782 - (39%)
• Gaps: 202/782 - (25%)

  Fly     7 IGIDLGTTYSCVGVWQ-NSKVEIIANDQGNRTTPSYVAFNETERLIGDPAKNQVAMNAKNTVFDA 70
            :.:|||:.:..|||.. ...:||..|.:..|.||:.:||...:|:.|:.|:........|:....
Mosquito    35 MSVDLGSEWMKVGVVSPGVPMEIALNKESKRKTPTTIAFRNGDRVFGEDAQTLGVRFPSNSFGYL 99

  Fly    71 KRLIGRKFDDKKIQEDLKLWPFKVINEKGKP-KIEVEFKGERKRFAPEEISSMVLTKMREIAEVY 134
            ..|:|:..|:..:....|.:|:..|  ...| :..|.|:...:::..||:.:.:|...:..||..
Mosquito   100 TDLLGKTVDNPMVDLYRKRFPYYDI--VADPVRRTVVFRSGEEQYMIEELIAQLLQVAKSYAEDS 162

  Fly   135 LGGKVKDAVVTVPAYFNDSQRQATKDAGSIAGLNVLRIINEPTAAALAYGLDKNLKGERN----- 194
            .|..:.:.|:.||.::..::|.|...|..:|.|.||::||:.||.||.||:.:  :.|.|
Mosquito   163 TGQLITECVLIVPGFYGQAERTALVAAARLANLKVLQLINDYTAVALNYGIFR--RKEINETAQY 225

  Fly   195 VLIFDLGGGTFDVSVLSIDEGSLFEVKATAGDTH-------------LGGEDFDNRLVNHFAEEF 246
            .|.:|:|......:|:|.   .|.:.|||. :||             |||.:...||.::...||
Mosquito   226 FLFYDMGAYKTSAAVVSY---QLVKDKATR-ETHPVVQVLGVGYDRTLGGLEMQVRLRDYLGREF 286

  Fly   247 KR--KHKSDIKGNARALRRLRTACERAKRTLSSSTEASLEIDALHEGIDFYSKISRARFEELNMD 309
            .:  |.|:|:..|.||:.:|.....|.|..||::||...:|:.|.:..||...:.|.:||||..|
Mosquito   287 NKMGKTKTDVFTNPRAMAKLFKEAGRLKNVLSANTEHYAQIEGLLDEQDFRLLVKREQFEELCKD 351

  Fly   310 LFRSTMQPVERALSDAKMDKKAIHDVVLVGGSTRIPKIQKLLQDLFGGKQLNLSINPDEAVAYGA 374
            |:.....|:::||:.:.:....|:.|||.||:||:||:|.:|:... |::|..::|.|||...||
Mosquito   352 LYERVTAPLDKALAVSGLALDVINQVVLFGGNTRVPKVQDILRTHI-GQELAKNLNADEAACMGA 415

  Fly   375 AVQAA-ILTGVGSSQIQDLLLVDVA--PLSLGIETAG-GVMTNLVERNA-----RIPCKQQQIFT 430
            ..:|| :.||.   :::..:..|..  |:.:..:..| ...|..|.|..     ..|.|:...|.
Mosquito   416 VYRAADLATGF---KVKKFITKDAVLFPIQVVFDREGESGATRQVRRTLFGSMNSYPQKKVITFN 477

  Fly   431 TYSDNQNAVTIQVYEGERAMTKDNNLLGT------------------------------------ 459
            .::|:.. .|:|..|.:..:..|...||:
Mosquito   478 KHTDDFE-FTVQYAELDAVLKGDTETLGSPDLARVQLSEVAKRLKASVAENVESKGIKAHFLLDD 541

  Fly   460 ---FNLTGI-------------------------------------------PPAPRGVP----- 473
               |:|..:                                           ||...|..
Mosquito   542 SGIFSLANVELVLEKTVTKEEEDEDESTFQKIGNTISKLFSGDSADKPAEEKPPTEGGAEAKDEE 606

  Fly   474 -----------------------QIEVAFDLNADGILNVNAKD---------------------N 494
                                   :.:.|.|..|||    .|||                     |
Mosquito   607 EPASGKEGKESAEEEQQQQQEEGKKQSAKDKEADG----GAKDAKPEAGEPADKKAADEGTEAKN 667

  Fly   495 STGKSEKITISND-------------KGRLSKAEIDRM--LSEAEKYKVEDDRQRERVQSKNNLE 544
            :|.|.:.:|:...             .|.|..|...|:  |.|.:|.|      :.|..:.|.||
Mosquito   668 ATVKPKIVTLKEPIPSKVELAYVVPLDGELFDASAKRLSALDEVDKAK------QRRETALNALE 726

  Fly   545 AYIYACRQAVDDAP-SGVLSETERSKVRDKCSSEASWL-DKNSLAEKEEFESHLKECQRICTPIM 607
            :|:...:..:|:.. :...:|||...:|.:|...:.|| :..|.|:.|.:|:.|:|.:.:...:.
Mosquito   727 SYVIDAQVKLDEQEYASCATETEIETIRKRCGEISEWLYEDGSDADAETYETKLEELRGVANEVY 791

  Fly   608 SK 609
            ::
Mosquito   792 AR 793

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-2	NP_524339.1	PTZ00009	1..632	CDD:240227	182/782 (23%)
Grp170	XP_321225.4	None