DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-2 and Hyou1

DIOPT Version :9

Sequence 1:	NP_524339.1	Gene:	Hsc70-2 / 41609	FlyBaseID:	FBgn0001217	Length:	633	Species:	Drosophila melanogaster
Sequence 2:	NP_067370.3	Gene:	Hyou1 / 12282	MGIID:	108030	Length:	999	Species:	Mus musculus

Alignment Length:	801	Identity:	193/801 - (24%)
Similarity:	341/801 - (42%)	Gaps:	205/801 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IPAIGIDLGTTYSCVGVWQ-NSKVEIIANDQGNRTTPSYVAFNETERLIGDPAKNQVAMNAKNTV 67
            :..:.:|||:....|.:.: ...:||:.|.:..|.||..|...|.||.:||.|......|.|.|:
Mouse    33 LAVMSVDLGSESMKVAIVKPGVPMEIVLNKESRRKTPVTVTLKENERFLGDSAAGMAIKNPKATL 97

  Fly    68 FDAKRLIGRKFDDKKIQEDLKLWPFKVINEKGKPKIEVEFKGERK----------RFAPEEISSM 122
            ...:.|:|::.|:          |...:.....|:.|:....:|:          :|:|||:..|
Mouse    98 RYFQHLLGKQADN----------PHVALYRSRFPEHELIVDPQRQTVRFQISPQLQFSPEEVLGM 152

  Fly   123 VLTKMREIAEVYLGGKVKDAVVTVPAYFNDSQRQATKDAGSIAGLNVLRIINEPTAAALAYGL-- 185
            ||...|.:||.:....:||||:||||:||.::|:|...|..:|||.||::||:.||.||:||:
Mouse   153 VLNYSRSLAEDFAEQPIKDAVITVPAFFNQAERRAVLQAARMAGLKVLQLINDNTATALSYGVFR 217

  Fly   186 --DKNLKGERNVLIFDLGGGTFDVSVLSID-----EGSL---FEVKATAGDTHLGGEDFDNRLVN 240
              |.|...: ||:.:|:|.|:...::::..     |..:   .:::....|..|||.:.:.||..
Mouse   218 RKDINSTAQ-NVMFYDMGSGSTVCTIVTYQTVKTKEAGMQPQLQIRGVGFDRTLGGLEMELRLRE 281

  Fly   241 HFAEEFKRKHK----SDIKGNARALRRLRTACERAKRTLSSSTEASLEIDALHEGIDFYSKISRA 301
            |.|:.|..:.|    .|::.|.||:.:|.....|.|..||::.:...:|:.|.:.:||.:|::|.
Mouse   282 HLAKLFNEQRKGQKAKDVRENPRAMAKLLREANRLKTVLSANADHMAQIEGLMDDVDFKAKVTRV 346

  Fly   302 RFEELNMDLFRSTMQPVERALSDAKMDKKAIHDVVLVGGSTRIPKIQKLLQDLFGGKQLNLSINP 366
            .||||..|||.....||::||..|:|....|..|:||||:||:||:|::|....|.::|..:||.
Mouse   347 EFEELCADLFDRVPGPVQQALQSAEMSLDQIEQVILVGGATRVPKVQEVLLKAVGKEELGKNINA 411

  Fly   367 DEAVAYGAAVQAAILT---GVGSSQIQDLLLVDV-APLSLGIETAGGVMTNLVERNARI------ 421
            |||.|.||..|||.|:   .|....::|.::..: ...:..:|...|:.:  ::.|.|:
Mouse   412 DEAAAMGAVYQAAALSKAFKVKPFVVRDAVIYPILVEFTREVEEEPGLRS--LKHNKRVLFSRMG 474

  Fly   422 PCKQQQI--FTTYSDNQNAVTIQVYEGERAM--TKDNNLLGTFNLT-----GIPPAPRGVPQ--- 474
            |..|:::  |..||.:.|   ..:..|:...  .:|..:.|:.|||     |:..:.:..|.
Mouse   475 PYPQRKVITFNRYSHDFN---FHINYGDLGFLGPEDLRVFGSQNLTTVKLKGVGESFKKYPDYES 536

  Fly   475 --IEVAFDLNADGILNV--------------------------------------NAKDNST--- 496
              |:..|:|:..|:|::                                      :||:|.|
Mouse   537 KGIKAHFNLDESGVLSLDRVESVFETLVEDSPEEESTLTKLGNTISSLFGGGTSSDAKENGTDAV 601

  Fly   497 --------------------------------------------------------GKSEKITIS 505
                                                                    |...:....
Mouse   602 QEEEESPAEGSKDEPAEQGELKEEAEPPAEETSQPPPSEPKGDAAREGEKPDEKESGDKPEAQKP 666

  Fly   506 NDKGR---------------------------------------LSKAEIDRMLSEAEKYKVEDD 531
            |:||:                                       |.:.|:.|.:.:.|:..:.|.
Mouse   667 NEKGQAGPEGAAPAPEEDKKPKPARKQKMVEEIGVELAVLDLPDLPEDELARSVQKLEELTLRDL 731

  Fly   532 RQRERVQSKNNLEAYIYACRQAV-DDAPSGVLSETERSKVRDKCSSEASWL-DKNSLAEKEEFES 594
            .::||.::.|:|||:|:..:..: ......|.:|.:|.::..|.|:.::|| |:...|.....:.
Mouse   732 EKQEREKAANSLEAFIFETQDKLYQPEYQEVSTEEQREEISGKLSATSTWLEDEGFGATTVMLKD 796

  Fly   595 HLKECQRICTPIMSKIHGGKK 615
            .|.|.:::|..:..::...:|
Mouse   797 KLAELRKLCQGLFFRVEERRK 817

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-2	NP_524339.1	PTZ00009	1..632	CDD:240227	193/801 (24%)
Hsc70-2	NP_524339.1	HSPA1-2_6-8-like_NBD	6..382	CDD:212675	134/402 (33%)
Hyou1	NP_067370.3	HYOU1-like_NBD	36..424	CDD:212672	132/398 (33%)
		MDN1	<554..767	CDD:227596	22/212 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	567..694		8/126 (6%)
		PHA03169	<586..>691	CDD:223003	8/104 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	909..999
		Prevents secretion from ER. /evidence=ECO:0000255	996..999
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810