DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hsc70-2 and HYOU1

DIOPT Version :9

Sequence 1:	NP_524339.1	Gene:	Hsc70-2 / 41609	FlyBaseID:	FBgn0001217	Length:	633	Species:	Drosophila melanogaster
Sequence 2:	XP_005271449.1	Gene:	HYOU1 / 10525	HGNCID:	16931	Length:	1000	Species:	Homo sapiens

Alignment Length:	801	Identity:	192/801 - (23%)
Similarity:	342/801 - (42%)	Gaps:	205/801 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IPAIGIDLGTTYSCVGVWQ-NSKVEIIANDQGNRTTPSYVAFNETERLIGDPAKNQVAMNAKNTV 67
            :..:.:|||:....|.:.: ...:||:.|.:..|.||..|...|.||..||.|.:....|.|.|:
Human    33 LAVMSVDLGSESMKVAIVKPGVPMEIVLNKESRRKTPVIVTLKENERFFGDSAASMAIKNPKATL 97

  Fly    68 FDAKRLIGRKFDDKKIQEDLKLWPFKVINEKGKPKIEVEFKGERK----------RFAPEEISSM 122
            ...:.|:|::.|:          |...:.:...|:.|:.|..:|:          :|:|||:..|
Human    98 RYFQHLLGKQADN----------PHVALYQARFPEHELTFDPQRQTVHFQISSQLQFSPEEVLGM 152

  Fly   123 VLTKMREIAEVYLGGKVKDAVVTVPAYFNDSQRQATKDAGSIAGLNVLRIINEPTAAALAYGL-- 185
            ||...|.:||.:....:||||:|||.:||.::|:|...|..:|||.||::||:.||.||:||:
Human   153 VLNYSRSLAEDFAEQPIKDAVITVPVFFNQAERRAVLQAARMAGLKVLQLINDNTATALSYGVFR 217

  Fly   186 --DKNLKGERNVLIFDLGGGTFDVSVLSID-----EGSL---FEVKATAGDTHLGGEDFD----N 236
              |.|...: |::.:|:|.|:...::::..     |..:   .:::....|..|||.:.:    .
Human   218 RKDINTTAQ-NIMFYDMGSGSTVCTIVTYQMVKTKEAGMQPQLQIRGVGFDRTLGGLEMELRLRE 281

  Fly   237 RLVNHFAEEFKRKHKSDIKGNARALRRLRTACERAKRTLSSSTEASLEIDALHEGIDFYSKISRA 301
            ||...|.|:.|.:...|::.|.||:.:|.....|.|..||::.:...:|:.|.:.:||.:|::|.
Human   282 RLAGLFNEQRKGQRAKDVRENPRAMAKLLREANRLKTVLSANADHMAQIEGLMDDVDFKAKVTRV 346

  Fly   302 RFEELNMDLFRSTMQPVERALSDAKMDKKAIHDVVLVGGSTRIPKIQKLLQDLFGGKQLNLSINP 366
            .||||..|||.....||::||..|:|....|..|:||||:||:|::|::|....|.::|..:||.
Human   347 EFEELCADLFERVPGPVQQALQSAEMSLDEIEQVILVGGATRVPRVQEVLLKAVGKEELGKNINA 411

  Fly   367 DEAVAYGAAVQAAILT---GVGSSQIQDLLLVDV-APLSLGIETAGGVMTNLVERNARI------ 421
            |||.|.||..|||.|:   .|....::|.::..: ...:..:|...|:  :.::.|.|:
Human   412 DEAAAMGAVYQAAALSKAFKVKPFVVRDAVVYPILVEFTREVEEEPGI--HSLKHNKRVLFSRMG 474

  Fly   422 PCKQQQI--FTTYSDNQNAVTIQVYEGERAM--TKDNNLLGTFNLT-----GIPPAPRGVPQ--- 474
            |..|:::  |..||.:.|   ..:..|:...  .:|..:.|:.|||     |:..:.:..|.
Human   475 PYPQRKVITFNRYSHDFN---FHINYGDLGFLGPEDLRVFGSQNLTTVKLKGVGDSFKKYPDYES 536

  Fly   475 --IEVAFDLNADGILNV--------------------------------------NAKDN----- 494
              |:..|:|:..|:|::                                      :||:|
Human   537 KGIKAHFNLDESGVLSLDRVESVFETLVEDSAEEESTLTKLGNTISSLFGGGTTPDAKENGTDTV 601

  Fly   495 -------------------------------------------STGKSEKIT--ISNDKGRLSK- 513
                                                       :|.:.||.|  .:.||....|
Human   602 QEEEESPAEGSKDEPGEQVELKEEAEAPVEDGSQPPPPEPKGDATPEGEKATEKENGDKSEAQKP 666

  Fly   514 ------------------------------AEI--------------DRMLSEAEKYK---VEDD 531
                                          .||              |::....:|.:   :.|.
Human   667 SEKAEAGPEGVAPAPEGEKKQKPARKRRMVEEIGVELVVLDLPDLPEDKLAQSVQKLQDLTLRDL 731

  Fly   532 RQRERVQSKNNLEAYIYACRQAV-DDAPSGVLSETERSKVRDKCSSEASWLDKNSL-AEKEEFES 594
            .::||.::.|:|||:|:..:..: ......|.:|.:|.::..|.|:.::||:...: |.....:.
Human   732 EKQEREKAANSLEAFIFETQDKLYQPEYQEVSTEEQREEISGKLSAASTWLEDEGVGATTVMLKE 796

  Fly   595 HLKECQRICTPIMSKIHGGKK 615
            .|.|.:::|..:..::...||
Human   797 KLAELRKLCQGLFFRVEERKK 817

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hsc70-2	NP_524339.1	PTZ00009	1..632	CDD:240227	192/801 (24%)
Hsc70-2	NP_524339.1	HSPA1-2_6-8-like_NBD	6..382	CDD:212675	131/402 (33%)
HYOU1	XP_005271449.1	HSP70	35..672	CDD:278441	167/652 (26%)
		NBD_sugar-kinase_HSP70_actin	36..424	CDD:302596	129/398 (32%)
		PHA00666	601..>739	CDD:222808	14/137 (10%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810