DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11670 and MASP1

DIOPT Version :9

Sequence 1:	NP_001368950.1	Gene:	CG11670 / 41608	FlyBaseID:	FBgn0038114	Length:	431	Species:	Drosophila melanogaster
Sequence 2:	XP_011511291.1	Gene:	MASP1 / 5648	HGNCID:	6901	Length:	735	Species:	Homo sapiens

Alignment Length:	294	Identity:	82/294 - (27%)
Similarity:	132/294 - (44%)	Gaps:	65/294 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   172 GRSIVAPGQYPHMAALGFRNENHEIDYKC--GGSLISEEFVLTAAHCLTTHGTSPDIVKIG---- 230
            ||: ..||.:|..|.:...:.:...:.|.  .|:|:|..::|||||.|.:......::.:.
Human   460 GRN-AEPGLFPWQALIVVEDTSRVPNDKWFGSGALLSASWILTAAHVLRSQRRDTTVIPVSKEHV 523

  Fly   231 -------DIKLKEWELNVAPQRRRVAQIYLHPLYNASLNYHDIGLIQLNRPVEYTWFVRPV---R 285
                   |::.|...:|.:     .|::.|||.:|.....|||.|:||..||.....|.||   |
Human   524 TVYLGLHDVRDKSGAVNSS-----AARVVLHPDFNIQNYNHDIALVQLQEPVPLGPHVMPVCLPR 583

  Fly   286 LWPMNDIPYGKLHTMG-YGSTGFAQPQ--------------TNILTELDLSVVPIEQCNSSLPAD 335
            |.|....|    |.:| ....|.:.|.              :::|..:.|.|||..:|.:|..:.
Human   584 LEPEGPAP----HMLGLVAGWGISNPNVTVDEIISSGTRTLSDVLQYVKLPVVPHAECKTSYESR 644

  Fly   336 EGSPHGLLTSQICAHDYEKNRDTCQGDSGGPLQL--NLERRRRRHTSRKHYRYYLVGITSYGA-- 396
            .|: :.:..:..||..||..:|||.|||||...:  :|.:           |:.:.|:.|:|.
Human   645 SGN-YSVTENMFCAGYYEGGKDTCLGDSGGAFVIFDDLSQ-----------RWVVQGLVSWGGPE 697

  Fly   397 YCRS-ELPGVYTRVSSYIDWI-------ASIVWP 422
            .|.| ::.||||:||:|:||:       .|:|.|
Human   698 ECGSKQVYGVYTKVSNYVDWVWEQMGLPQSVVEP 731

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11670	NP_001368950.1	Tryp_SPc	172..419	CDD:238113	79/289 (27%)
MASP1	XP_011511291.1	CUB	35..144	CDD:238001
		FXa_inhibition	160..188	CDD:291342
		CUB	192..301	CDD:278839
		Sushi	308..369	CDD:278512
		CCP	374..439	CDD:153056
		Tryp_SPc	456..718	CDD:214473	78/279 (28%)
		Tryp_SPc	457..718	CDD:238113	78/279 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910