DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment snk and Tmprss12

DIOPT Version :9

Sequence 1:	NP_001097766.1	Gene:	snk / 41607	FlyBaseID:	FBgn0003450	Length:	435	Species:	Drosophila melanogaster
Sequence 2:	NP_898932.2	Gene:	Tmprss12 / 75002	MGIID:	1922252	Length:	336	Species:	Mus musculus

Alignment Length:	249	Identity:	81/249 - (32%)
Similarity:	129/249 - (51%)	Gaps:	20/249 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   186 IVGGTPTRHGLFPHMAALGWTQGSGSKDQDIKWG-CGGALVSELYVLTAAHCATSGSKPPDMVR- 248
            |:||:....|.:|      |......:|.||... ||||||.:.:||||||| |..::.|...|
Mouse    66 IIGGSQADTGAWP------WQVSLQVQDGDILMHVCGGALVRDRWVLTAAHC-TKEARDPLKWRA 123

  Fly   249 -LGARQLNETSATQQDIKILIIVLHPKYRSSAYYHDIALLKLTRRVKFSEQVRPACL----WQLP 308
             :|...|..:....::|:|..|::.|.:....:.:||||.:|.|.|::::.::|.||    :|..
Mouse   124 VMGTNDLTRSPYHSRNIRITDIIIPPDFIMETFVNDIALFRLKRAVRYNDYIQPICLPFGVFQKL 188

  Fly   309 ELQIPTVVAAGWGRTEFLGAKSNALRQVDLDVVPQMTCKQIYRKERRLPRGIIEGQFCAGYLPGG 373
            : |......:|||||...|..:..|::..:..:.:..|.........:|    ...||||:..|.
Mouse   189 D-QNTACFISGWGRTREEGNGTTILQEAKVHFISREVCSSDQGYSGMIP----NTSFCAGHENGT 248

  Fly   374 RDTCQGDSGGPIHALLPEYNCVAFVVGITSFGKFCAAPNAPGVYTRLYSYLDWI 427
            .|:|:||||||:...|||::.. ||:||||:|..|...:.||||:....:.:|:
Mouse   249 FDSCRGDSGGPLMCYLPEHSRY-FVMGITSYGHGCGRRHFPGVYSNPSFFQEWM 301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
snk	NP_001097766.1	CLIP	93..139	CDD:197829
		Tryp_SPc	186..430	CDD:238113	81/249 (33%)
		Tryp_SPc	186..427	CDD:214473	80/247 (32%)
Tmprss12	NP_898932.2	Tryp_SPc	65..300	CDD:214473	80/246 (33%)
Tmprss12	NP_898932.2	Tryp_SPc	66..300	CDD:238113	80/246 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BF5U
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810