DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment snk and GZMA

DIOPT Version :9

Sequence 1:NP_001097766.1 Gene:snk / 41607 FlyBaseID:FBgn0003450 Length:435 Species:Drosophila melanogaster
Sequence 2:NP_006135.2 Gene:GZMA / 3001 HGNCID:4708 Length:262 Species:Homo sapiens


Alignment Length:257 Identity:78/257 - (30%)
Similarity:111/257 - (43%) Gaps:46/257 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   186 IVGGTPTRHGLFPHMAALGWTQGSGSKDQDIKWGCGGALVSELYVLTAAHCATSGSKPPDMVRLG 250
            |:||........|:|..|         ..|.|..|.|||:::.:|||||||   .......|.||
Human    29 IIGGNEVTPHSRPYMVLL---------SLDRKTICAGALIAKDWVLTAAHC---NLNKRSQVILG 81

  Fly   251 ARQLNETSATQQDIKILIIVLHPKYRSSAYYHDIALLKLTRRVKFS------------EQVRPAC 303
            |..:.....|:|.:.:.....:|.|..:....|:.||:|..:.|.:            :.|:|..
Human    82 AHSITREEPTKQIMLVKKEFPYPCYDPATREGDLKLLQLMEKAKINKYVTILHLPKKGDDVKPGT 146

  Fly   304 LWQLPELQIPTVVAAGWGRTEFLGAKSNALRQVDLDVVPQMTCKQIYRKERRLPRGIIEGQFCAG 368
            :.|:          ||||||....:.|:.||:|::.::.:..|..  |........|.....|||
Human   147 MCQV----------AGWGRTHNSASWSDTLREVNITIIDRKVCND--RNHYNFNPVIGMNMVCAG 199

  Fly   369 YLPGGRDTCQGDSGGPIHALLPEYNCVAFVVGITSFG--KFCAAPNAPGVYTRL-YSYLDWI 427
            .|.||||:|.||||.|:       .|.....|:||||  ..|..|..||||..| ..:|:||
Human   200 SLRGGRDSCNGDSGSPL-------LCEGVFRGVTSFGLENKCGDPRGPGVYILLSKKHLNWI 254

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
snkNP_001097766.1 CLIP 93..139 CDD:197829
Tryp_SPc 186..430 CDD:238113 78/257 (30%)
Tryp_SPc 186..427 CDD:214473 76/255 (30%)
GZMANP_006135.2 Tryp_SPc 29..254 CDD:238113 76/255 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D476534at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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