Protein Alignment snk and TMPRSS12

DIOPT Version :10

• Sequence 1: NP_524338.2
• Gene: snk / 41607
• FlyBaseID: FBgn0003450
• Length: 435
• Species: Drosophila melanogaster
• Sequence 2: NP_872365.2
• Gene: TMPRSS12 / 283471
• HGNCID: 28779
• Length: 348
• Species: Homo sapiens
• Alignment Length: 309
• Identity: 99/309 - (32%)
• Similarity: 143/309 - (46%)
• Gaps: 56/309 - (18%)

  Fly   152 ATKCQEYNAAARRL--------HLTDTGRTFSGKQCVPSVPL--------IVGGTPTRHGLFPHM 200
            |...|:..|..:||        |..|.|          :.||        |:|||..:.|.:|.:
Human    38 AASSQQAEAVRKRLRRRREGGAHAEDCG----------TAPLKDVLQGSRIIGGTEAQAGAWPWV 92

  Fly   201 AALGWTQGSGSKDQDIKWG------CGGALVSELYVLTAAHCATSGSKPPDMVR-LGARQLNETS 258
            .:|           .||:|      |||.||.|.:|||||||....|.|..... :|...::...
Human    93 VSL-----------QIKYGRVLVHVCGGTLVRERWVLTAAHCTKDASDPLMWTAVIGTNNIHGRY 146

  Fly   259 ATQQDIKILIIVLHPKYRSSAYYHDIALLKLTRRVKFSEQVRPACL----WQLPELQIPTVVAAG 319
            ...:.|||..|::||.:...:|.:||||..|.:.|::::.::|.||    :|:.:......: :|
Human   147 PHTKKIKIKAIIIHPNFILESYVNDIALFHLKKAVRYNDYIQPICLPFDVFQILDGNTKCFI-SG 210

  Fly   320 WGRTEFLGAKSNALRQVDLDVVPQMTCKQIYRKERRLPRGIIEG-QFCAGYLPGGRDTCQGDSGG 383
            ||||:..|..:|.|:..::..:.:..|     ...|...|||.. .||||...|..|||:|||||
Human   211 WGRTKEEGNATNILQDAEVHYISREMC-----NSERSYGGIIPNTSFCAGDEDGAFDTCRGDSGG 270

  Fly   384 PIHALLPEYNCVAFVVGITSFGKFCAAPNAPGVYTRLYSYLDWIEKIAF 432
            |:...||||... ||:||||:|..|.....||||.....|..|:.:..|
Human   271 PLMCYLPEYKRF-FVMGITSYGHGCGRRGFPGVYIGPSFYQKWLTEHFF 318

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
snk	NP_524338.2	CLIP	93..139	CDD:197829
		Tryp_SPc	186..430	CDD:238113	88/255 (35%)
TMPRSS12	NP_872365.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	24..46		2/7 (29%)
		Tryp_SPc	78..316	CDD:238113	88/255 (35%)