DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment snk and TMPRSS12

DIOPT Version :9

Sequence 1:	NP_001097766.1	Gene:	snk / 41607	FlyBaseID:	FBgn0003450	Length:	435	Species:	Drosophila melanogaster
Sequence 2:	NP_872365.2	Gene:	TMPRSS12 / 283471	HGNCID:	28779	Length:	348	Species:	Homo sapiens

Alignment Length:	309	Identity:	99/309 - (32%)
Similarity:	143/309 - (46%)	Gaps:	56/309 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 ATKCQEYNAAARRL--------HLTDTGRTFSGKQCVPSVPL--------IVGGTPTRHGLFPHM 200
            |...|:..|..:||        |..|.|          :.||        |:|||..:.|.:|.:
Human    38 AASSQQAEAVRKRLRRRREGGAHAEDCG----------TAPLKDVLQGSRIIGGTEAQAGAWPWV 92

  Fly   201 AALGWTQGSGSKDQDIKWG------CGGALVSELYVLTAAHCATSGSKPPDMVR-LGARQLNETS 258
            .:|           .||:|      |||.||.|.:|||||||....|.|..... :|...::...
Human    93 VSL-----------QIKYGRVLVHVCGGTLVRERWVLTAAHCTKDASDPLMWTAVIGTNNIHGRY 146

  Fly   259 ATQQDIKILIIVLHPKYRSSAYYHDIALLKLTRRVKFSEQVRPACL----WQLPELQIPTVVAAG 319
            ...:.|||..|::||.:...:|.:||||..|.:.|::::.::|.||    :|:.:......: :|
Human   147 PHTKKIKIKAIIIHPNFILESYVNDIALFHLKKAVRYNDYIQPICLPFDVFQILDGNTKCFI-SG 210

  Fly   320 WGRTEFLGAKSNALRQVDLDVVPQMTCKQIYRKERRLPRGIIEG-QFCAGYLPGGRDTCQGDSGG 383
            ||||:..|..:|.|:..::..:.:..|     ...|...|||.. .||||...|..|||:|||||
Human   211 WGRTKEEGNATNILQDAEVHYISREMC-----NSERSYGGIIPNTSFCAGDEDGAFDTCRGDSGG 270

  Fly   384 PIHALLPEYNCVAFVVGITSFGKFCAAPNAPGVYTRLYSYLDWIEKIAF 432
            |:...||||... ||:||||:|..|.....||||.....|..|:.:..|
Human   271 PLMCYLPEYKRF-FVMGITSYGHGCGRRGFPGVYIGPSFYQKWLTEHFF 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
snk	NP_001097766.1	CLIP	93..139	CDD:197829
		Tryp_SPc	186..430	CDD:238113	88/255 (35%)
		Tryp_SPc	186..427	CDD:214473	87/252 (35%)
TMPRSS12	NP_872365.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	24..63		6/24 (25%)
TMPRSS12	NP_872365.2	Tryp_SPc	78..316	CDD:238113	88/255 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BF5U
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810