DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment snk and CMA1

DIOPT Version :9

Sequence 1:	NP_001097766.1	Gene:	snk / 41607	FlyBaseID:	FBgn0003450	Length:	435	Species:	Drosophila melanogaster
Sequence 2:	NP_001827.1	Gene:	CMA1 / 1215	HGNCID:	2097	Length:	247	Species:	Homo sapiens

Alignment Length:	250	Identity:	83/250 - (33%)
Similarity:	116/250 - (46%)	Gaps:	33/250 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   186 IVGGTPTRHGLFPHMAALGWTQGSG-SKDQDIKWGCGGALVSELYVLTAAHCATSGSKPPDMVRL 249
            |:|||..:....|:||.|.....:| ||      .|||.|:...:||||||||....    .|.|
Human    22 IIGGTECKPHSRPYMAYLEIVTSNGPSK------FCGGFLIRRNFVLTAAHCAGRSI----TVTL 76

  Fly   250 GARQLNETSATQQDIKILIIVLHPKYRSSAYYHDIALLKLTRRVKFSEQVR----PACLWQLPEL 310
            ||..:.|...|.|.::::....||||.:|..:|||.||||..:...:..|.    |:....:|..
Human    77 GAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLAVGTLPFPSQFNFVPPG 141

  Fly   311 QIPTVVAAGWGRTEFLGAKSNALRQVDLDVVPQMTCKQIYRKERRLPRGIIEGQFCAGYLPGGRD 375
            ::..|  ||||||..|...|:.|::|.|.::....|......:..|       |.|.|.....:.
Human   142 RMCRV--AGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRDFDHNL-------QLCVGNPRKTKS 197

  Fly   376 TCQGDSGGPIHALLPEYNCVAFVVGITSFGKFCAAPNAPGVYTRLYSYLDWIEKI 430
            ..:||||||:       .|.....||.|:|:..|.|  |.|:||:..|..||.:|
Human   198 AFKGDSGGPL-------LCAGVAQGIVSYGRSDAKP--PAVFTRISHYRPWINQI 243

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
snk	NP_001097766.1	CLIP	93..139	CDD:197829
		Tryp_SPc	186..430	CDD:238113	82/248 (33%)
		Tryp_SPc	186..427	CDD:214473	80/245 (33%)
CMA1	NP_001827.1	Tryp_SPc	22..243	CDD:238113	82/248 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6142
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.860