DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment snk and tmprss12

DIOPT Version :9

Sequence 1:	NP_001097766.1	Gene:	snk / 41607	FlyBaseID:	FBgn0003450	Length:	435	Species:	Drosophila melanogaster
Sequence 2:	XP_031751504.1	Gene:	tmprss12 / 100127698	XenbaseID:	XB-GENE-964846	Length:	324	Species:	Xenopus tropicalis

Alignment Length:	253	Identity:	85/253 - (33%)
Similarity:	123/253 - (48%)	Gaps:	27/253 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   186 IVGGTPTRHGLFPHMAALGWTQG-SGSKDQDIKWGCGGALVSELYVLTAAHCATSGSKPPDMVR- 248
            ||||.....|.:|...:|.:.:. ||...:     |||:|:...:||:||||..: ::.|:..|
Frog    41 IVGGRNALPGAWPWQVSLQYFRTLSGYSHR-----CGGSLIQNNWVLSAAHCFRA-NRNPEYWRA 99

  Fly   249 -LGARQLNETSATQQDIKILIIVLHPKYRSSAYYHDIALLKLTRRVKFSEQVRPACLWQLPELQI 312
             ||...:....:.....||..|::|..|...|..:|||||.|...|.:|:.:.|.|   |..:.:
Frog   100 VLGLHNIFMEGSPVVKAKIKQIIIHASYDHIAITNDIALLLLHDFVTYSDYIHPVC---LGSVTV 161

  Fly   313 PTVVAA----GWGRTEFLGAKSNALRQVDLDVVPQMTCKQIYRKERRLPRGIIEGQFCAGYLPGG 373
            |..:.|    |||.|:..|:.|..|::..:..:|...|    .........|.:...|||...|.
Frog   162 PDSLTACFITGWGVTKEKGSISVILQEALVQTIPYSEC----NSSSSYNGFITQSMICAGDNSGA 222

  Fly   374 RDTCQGDSGGPIHALLPEYNCVA---FVVGITSFGKFCAAPNAPGVYTRLYSYLDWIE 428
            .|:||||||||...    ||...   :.:||||||..|..||.|||||::.||:.||:
Frog   223 VDSCQGDSGGPFVC----YNTERMRFYQMGITSFGYGCGKPNFPGVYTKVESYVSWIK 276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
snk	NP_001097766.1	CLIP	93..139	CDD:197829
		Tryp_SPc	186..430	CDD:238113	85/253 (34%)
		Tryp_SPc	186..427	CDD:214473	83/250 (33%)
tmprss12	XP_031751504.1	Tryp_SPc	41..278	CDD:238113	85/253 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910