DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11668 and F10

DIOPT Version :9

Sequence 1:	NP_650254.1	Gene:	CG11668 / 41606	FlyBaseID:	FBgn0038113	Length:	398	Species:	Drosophila melanogaster
Sequence 2:	NP_000495.1	Gene:	F10 / 2159	HGNCID:	3528	Length:	488	Species:	Homo sapiens

Alignment Length:	412	Identity:	95/412 - (23%)
Similarity:	164/412 - (39%)	Gaps:	123/412 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 NCQAHDRPLI----GKCVRYVDCISAMQAVPRVTPLLCPSSWPNQLVCCPHGGYLLPPPSISKSE 103
            ||:...|.|.    |.|.::                 |... .|.:||....||     :::.:.
Human   120 NCELFTRKLCSLDNGDCDQF-----------------CHEE-QNSVVCSCARGY-----TLADNG 161

  Fly   104 QAC--ANAYPRAHHKRRRRRRNT------------------------NPKLDQVELVEPIIQKHN 142
            :||  ...||.......||:|:.                        :|..:..:|::     .|
Human   162 KACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLD-----FN 221

  Fly   143 QSQ------NL--LVGGRLTQENEHPYMCALGWPSRTNRWIHEHGSSKRRYTFNCGCAMIAPRFA 199
            |:|      ||  :|||:..::.|.|:...|         |:|....      .||..:::..:.
Human   222 QTQPERGDNNLTRIVGGQECKDGECPWQALL---------INEENEG------FCGGTILSEFYI 271

  Fly   200 ITAAHC--------ASVGGESPSVALIGGVELNSGRGQLIEIKRISQHPHFDAETLTNDLAVVKL 256
            :|||||        ..||..:        .|...|...:.|::.:.:|..|..||...|:||::|
Human   272 LTAAHCLYQAKRFKVRVGDRN--------TEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRL 328

  Fly   257 AR----RSHMPVACL----WNQESL-PERPLTALGYGQTKFAGPHSSNLLQIMLYHLNFQQCQRY 312
            ..    |.::..|||    |.:.:| .::.....|:|:|...|..|:.|..:.:.:::...|
Human   329 KTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSC--- 390

  Fly   313 LHNYDKLANG--LGSGQMCAGDYSGNMDTCQGDSGGPLLLHQHMRHHRHTIPYVVGITSFGGACA 375
                 ||::.  :.....|||..:...|.||||||||     |:...:.|. :|.||.|:|..||
Human   391 -----KLSSSFIITQNMFCAGYDTKQEDACQGDSGGP-----HVTRFKDTY-FVTGIVSWGEGCA 444

  Fly   376 -SGQPGVYVRIAHYIQWIEQQV 396
             .|:.|:|.::..:::||::.:
Human   445 RKGKYGIYTKVTAFLKWIDRSM 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11668	NP_650254.1	Tryp_SPc	149..395	CDD:238113	69/265 (26%)
CG11668	NP_650254.1	Tryp_SPc	149..392	CDD:214473	67/262 (26%)
F10	NP_000495.1	GLA	25..85	CDD:214503
		EGF_CA	86..122	CDD:238011	1/1 (100%)
		FXa_inhibition	129..164	CDD:317114	8/57 (14%)
		O-glycosylated at one site	183..203		0/19 (0%)
		Tryp_SPc	235..464	CDD:238113	69/265 (26%)
		O-glycosylated at one site	476..485
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910