DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ry and XDH2

DIOPT Version :9

Sequence 1:	NP_524337.1	Gene:	ry / 41605	FlyBaseID:	FBgn0003308	Length:	1335	Species:	Drosophila melanogaster
Sequence 2:	NP_195216.2	Gene:	XDH2 / 829642	AraportID:	AT4G34900	Length:	1353	Species:	Arabidopsis thaliana

Alignment Length:	1357	Identity:	611/1357 - (45%)
Similarity:	843/1357 - (62%)	Gaps:	73/1357 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VFFVNGKKVTEVSPD--PECTLLTFLREKLRLCGTKLGCAEGGCGACTVMVSRLDRRANKIRHLA 69
            :.:|||  |..|.||  ...|||.:||: |.|.||||||.|||||:||||||..||.:....|.|
plant    10 IMYVNG--VRRVLPDGLAHMTLLEYLRD-LGLTGTKLGCGEGGCGSCTVMVSSYDRESKTCVHYA 71

  Fly    70 VNACLTPVCSMHGCAVTTVEGIGSTKTRLHPVQERLAKAHGSQCGFCTPGIVMSMYALLRNAE-Q 133
            |||||.|:.|:.|..|.::||:|..|..|||:||.||.:|||||||||||.|||||||||::: .
plant    72 VNACLAPLYSVEGMHVISIEGVGHRKLGLHPLQESLASSHGSQCGFCTPGFVMSMYALLRSSKNS 136

  Fly   134 PSMRDLEVAFQGNLCRCTGYRPILEGYKTFTKE---FACGM-------GEKCCKVSGKGCGTDAE 188
            ||..::|....||||||||||||::.::.|.|.   ...|:       |...|..:||.|...::
plant   137 PSEEEIEECLAGNLCRCTGYRPIIDAFRVFAKSDDALYSGLSSLSLQDGSNICPSTGKPCSCGSK 201

  Fly   189 T-------DDKLFERSEFQPLD----PSQEPIFPPELQLSDAFDSQSLIFSSDRVTWYRPTNLEE 242
            |       ::..|:...:..:|    ..:|.||||||.|...  :...:..::.:|||||.:|:.
plant   202 TTSEAATCNEDRFQSISYSDIDGAKYTDKELIFPPELLLRKL--APLKLGGNEGITWYRPVSLQN 264

  Fly   243 LLQLKAKHPAAKLVVGNTEVGVEVKFKHFLYPHLINPTQVKELLEIKENQDGIYFGAAVSLMEID 307
            ||:|||..|.|||:|||||||:|::.|...||.||:..||.||..:..|.:||..|:|:.|.|:.
plant   265 LLELKANFPDAKLLVGNTEVGIEMRLKRLQYPVLISAAQVPELNALNVNDNGIEVGSALRLSELL 329

  Fly   308 ALLRQRIEQLPESETRLFQCTVDMLHYFAGKQIRNVACLGGNIMTGSPISDMNPVLSAAGAQLEV 372
            .|.|:.:::.|..||...:..::.|.:|||.|||||||:||||.|.|||||:||:..|:.|:..:
plant   330 RLFRKVVKERPAHETSACKAFIEQLKWFAGTQIRNVACIGGNICTASPISDLNPLWMASRAEFRI 394

  Fly   373 ASFVDGKLQKRSVHMGTGFFTGYRRNVIEAHEVLLGIHFRKTTPDQYIVAFKQARRRDDDIAIVN 437
            .: .:|.:  ||: ....||.|||:..:.::|:||.:....|.|.:|:..||||.||||||||||
plant   395 IN-CNGDV--RSI-PAKDFFLGYRKVDMGSNEILLSVFLPWTRPLEYVKEFKQAHRRDDDIAIVN 455

  Fly   438 AAINVRFEEKSN--IVAEISMAFGGMAPTTVLAPRTSQLMVGQEWSHQLVERVAESLCTELPLAA 500
            ..:.|..|||..  .|::.|:.:||:||.::.|..|.:|::|:.|:..|::...:.:.:::.:..
plant   456 GGMRVFLEEKGQQLFVSDASIVYGGVAPLSLRARNTEELLIGKNWNKCLLQDALKVIQSDVLIKE 520

  Fly   501 SAPGGMIAYRRALVVSLFFKAYLAISLKLSK----------SGITSSDALPSEERSGAETFHTPV 555
            .|||||:.:|::|.:|.|||.:|.::..::.          |.:::...:|...|.|.:.:.|
plant   521 GAPGGMVEFRKSLTLSFFFKFFLWVTHHVNNVNPTIETFPPSHMSAVQLVPRFSRIGKQDYET-- 583

  Fly   556 LKSAQLFERVCSDQPICDPIGRPKVHAAALKQATGEAIYTDDIPRMDGEVYLAFVLSTKPRAKIT 620
            :|..             ..:|.|:||.:|..|.||||.||||.|.....::.|.|||..|.|:|.
plant   584 VKQG-------------TSVGLPEVHLSARMQVTGEAEYTDDTPLPPCTLHAALVLSKVPHARIL 635

  Fly   621 KLDASEALALDGVHQFFCYKDLTEHENEVGPVFHDEHVFAAGEVHCYGQIVGAIAADNKALAQRA 685
            .:|.|.|.:..|....|..||:..: |.:||:..||.:||...|.|.||::|.:.||....|:.|
plant   636 SVDDSAAKSSSGFVGLFLAKDVPGN-NMIGPIVADEELFATDVVTCVGQVIGVLVADTHENAKTA 699

  Fly   686 ARLVKVEYEELSPVIVTIEQAIEHKSYFPDYPRFVTKGNVEEAL--AQADHTFEGTCRMGGQEHF 748
            ||.|.|.|:|| |.|::|::||..||:.|:..|.:.||:||...  .|.|...||..:|||||||
plant   700 ARKVDVRYQEL-PAILSIKEAINAKSFHPNTERRLRKGDVELCFQSGQCDRIIEGEVQMGGQEHF 763

  Fly   749 YLETHAALAVPRD-SDELELFCSTQHPSEVQKLVAHVTALPAHRVVCRAKRLGGGFGGKESRGIS 812
            |||.:.:|....| .:|:.:..|||.|.:.||.|:||..||..:|||:.|||||||||||:|...
plant   764 YLEPNGSLVWTIDGGNEVHMISSTQAPQQHQKYVSHVLGLPMSKVVCKTKRLGGGFGGKETRSAF 828

  Fly   813 VALPVALAAYRMGRPVRCMLDRDEDMLITGTRHPFLFKYKVGFTKEGLITACDIECYNNAGWSMD 877
            :|...::.:|.:.|||:.:||||.||:|||.||.|:.|||||||.||.|.|.|:|.|||.|.|||
plant   829 IAAAASVPSYLLNRPVKLILDRDVDMMITGHRHSFVGKYKVGFTNEGKILALDLEIYNNGGNSMD 893

  Fly   878 LSFSVLERAMFHFENCYRIPNVRVGGWVCKTNLPSNTAFRGFGGPQGMYAGEHIIRDVARIVGRD 942
            ||.|.|||||||.:|.|.||:||:.|.||.||.|||||||||||||||...|:.|:.:|..:.:.
plant   894 LSLSNLERAMFHSDNVYEIPHVRIVGNVCFTNFPSNTAFRGFGGPQGMLITENWIQRIAAELDKI 958

  Fly   943 VVDVMRLNFYKTGDYTHYHQQLEHFPIERCLEDCLKQSRYDEKRQEIARFNRENRWRKRGMAVVP 1007
            ..::..:||...|..|||.|.|:|..:.:..::....|.:.:.|:|...||..|||:|||:|:||
plant   959 PEEIKEMNFQVEGSITHYFQSLQHCTLHQLWKELKVSSNFLKTRREADEFNSHNRWKKRGVAMVP 1023

  Fly  1008 TKYGIAFGVMHLNQAGSLINIYGDGSVLLSHGGVEIGQGLNTKMIQCAARALGIPSELIHISETA 1072
            ||:||:|....:||||:|:::|.||:||::|||||:||||:||:.|.||.|..|....:.:|||:
plant  1024 TKFGISFTTKFMNQAGALVHVYTDGTVLVTHGGVEMGQGLHTKVAQVAATAFNILLSSVFVSETS 1088

  Fly  1073 TDKVPNTSPTAASVGSDLNGMAVLDACEKLNKRLAPIKEALPGGTWKEWINKAYFDRVSLSATGF 1137
            ||||||.||||||..||:.|.|||||||::..|:.|:.......|:.|..:..||.|:.|||.||
plant  1089 TDKVPNASPTAASASSDMYGAAVLDACEQIIARMEPVASKHNFNTFSELASACYFQRIDLSAHGF 1153

  Fly  1138 YAMPGIGYHPETNPNARTYSYYTNGVGVTVVEIDCLTGDHQVLSTDIVMDIGSSLNPAIDIGQIE 1202
            :.:|.:.: ...:.....|.|||.|.....||||.||||......||::|:|.||||.|||||||
plant  1154 HIVPELEF-DWVSGKGNAYRYYTYGAAFAEVEIDTLTGDFHTRKADIMLDLGYSLNPTIDIGQIE 1217

  Fly  1203 GAFMQGYGLFTLEELMYS-------PQGMLYSRGPGMYKLPGFADIPGEFNVSLLTGAPNPRAVY 1260
            |||:||.|...||||.:.       ..|.|.:.|||.||:|...|:|.:.|||||.|.||.:|::
plant  1218 GAFVQGLGWVALEELKWGDAAHKWIKPGSLLTCGPGSYKIPSINDMPFQLNVSLLKGNPNAKAIH 1282

  Fly  1261 SSKAVGEPPLFIGSSAFFAIKEAIAAAREDQGLSGDFPLEAPSTSARIRIACQDKFT 1317
            |||||||||.|:.:||||||||||.|||.:.||:..||||.|:|..|||:||.|:|:
plant  1283 SSKAVGEPPFFLAASAFFAIKEAIKAARSEVGLTNWFPLETPATPERIRMACFDEFS 1339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ry	NP_524337.1	Fer2	8..78	CDD:278537	41/71 (58%)
		PLN02906	25..1317	CDD:215491	603/1335 (45%)
		Fer2_2	87..158	CDD:280048	46/71 (65%)
		FAD_binding_5	231..411	CDD:279309	80/179 (45%)
		CO_deh_flav_C	422..525	CDD:281449	42/104 (40%)
		Ald_Xan_dh_C	589..696	CDD:279635	44/106 (42%)
		Ald_Xan_dh_C2	716..1242	CDD:280834	263/535 (49%)
XDH2	NP_195216.2	PLN02906	26..1344	CDD:215491	604/1339 (45%)
		Fer2_2	90..162	CDD:280048	46/71 (65%)
		FAD_binding_5	252..431	CDD:279309	80/182 (44%)
		CO_deh_flav_C	441..545	CDD:281449	42/103 (41%)
		Ald_Xan_dh_C	604..711	CDD:214971	46/108 (43%)
		Ald_Xan_dh_C2	730..1264	CDD:280834	263/534 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	514	1.000	Domainoid score	I66
eggNOG	1	0.900	-	-		E1_COG4631
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H324
Inparanoid	1	1.050	1108	1.000	Inparanoid score	I28
OMA	1	1.010	-	-		QHG54386
OrthoDB	1	1.010	-	-		D48717at2759
OrthoFinder	1	1.000	-	-		FOG0000201
OrthoInspector	1	1.000	-	-		otm2451
orthoMCL	1	0.900	-	-		OOG6_100184
Panther	1	1.100	-	-	O	PTHR11908
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X518
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840