DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ry and XDH

DIOPT Version :9

Sequence 1:	NP_524337.1	Gene:	ry / 41605	FlyBaseID:	FBgn0003308	Length:	1335	Species:	Drosophila melanogaster
Sequence 2:	NP_000370.2	Gene:	XDH / 7498	HGNCID:	12805	Length:	1333	Species:	Homo sapiens

Alignment Length:	1356	Identity:	706/1356 - (52%)
Similarity:	931/1356 - (68%)	Gaps:	48/1356 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSNSVLVFFVNGKKVTEVSPDPECTLLTFLREKLRLCGTKLGCAEGGCGACTVMVSRLDRRANKI 65
            |:...|||||||:||.|.:.|||.|||.:||.||.|.||||||.||||||||||:|:.||..|||
Human     1 MTADKLVFFVNGRKVVEKNADPETTLLAYLRRKLGLSGTKLGCGEGGCGACTVMLSKYDRLQNKI 65

  Fly    66 RHLAVNACLTPVCSMHGCAVTTVEGIGSTKTRLHPVQERLAKAHGSQCGFCTPGIVMSMYALLRN 130
            .|.:.||||.|:||:|..|||||||||||||||||||||:||:|||||||||||||||||.||||
Human    66 VHFSANACLAPICSLHHVAVTTVEGIGSTKTRLHPVQERIAKSHGSQCGFCTPGIVMSMYTLLRN 130

  Fly   131 AEQPSMRDLEVAFQGNLCRCTGYRPILEGYKTFTKEFAC----GMGEKCCKVSGKGCGTDAETDD 191
            ..:|:|.::|.||||||||||||||||:|::||.::..|    |....||....|  ........
Human   131 QPEPTMEEIENAFQGNLCRCTGYRPILQGFRTFARDGGCCGGDGNNPNCCMNQKK--DHSVSLSP 193

  Fly   192 KLFERSEFQPLDPSQEPIFPPE-LQLSDAFDSQSLIFSSDRVTWYRPTNLEELLQLKAKHPAAKL 255
            .||:..||.||||:|||||||| |:|.|. ..:.|.|..:||||.:.:.|:|||.|||:||.|||
Human   194 SLFKPEEFTPLDPTQEPIFPPELLRLKDT-PRKQLRFEGERVTWIQASTLKELLDLKAQHPDAKL 257

  Fly   256 VVGNTEVGVEVKFKHFLYPHLINPTQVKELLEIKENQDGIYFGAAVSLMEIDALLRQRIEQLPES 320
            ||||||:|:|:|||:.|:|.::.|..:.||..::...|||.||||..|..::..|...:.:||..
Human   258 VVGNTEIGIEMKFKNMLFPMIVCPAWIPELNSVEHGPDGISFGAACPLSIVEKTLVDAVAKLPAQ 322

  Fly   321 ETRLFQCTVDMLHYFAGKQIRNVACLGGNIMTGSPISDMNPVLSAAGAQLEVASFVDGKLQKRSV 385
            :|.:|:..::.|.:|||||:::||.:||||:|.|||||:|||..|:||:|.:.|    :..:|:|
Human   323 KTEVFRGVLEQLRWFAGKQVKSVASVGGNIITASPISDLNPVFMASGAKLTLVS----RGTRRTV 383

  Fly   386 HMGTGFFTGYRRNVIEAHEVLLGIHFRKTTPDQYIVAFKQARRRDDDIAIVNAAINVRFEEKSNI 450
            .|...||.|||:.::...|:||.|....:...:|..|||||.||:||||.|.:.:.|.|:..:..
Human   384 QMDHTFFPGYRKTLLSPEEILLSIEIPYSREGEYFSAFKQASRREDDIAKVTSGMRVLFKPGTTE 448

  Fly   451 VAEISMAFGGMAPTTVLAPRTSQLMVGQEWSHQLVERVAESLCTELPLAASAPGGMIAYRRALVV 515
            |.|:::.:||||..|:.|.:|:|..:.:.|..:|::.|...|..||.|...|||||:.:|..|.:
Human   449 VQELALCYGGMANRTISALKTTQRQLSKLWKEELLQDVCAGLAEELHLPPDAPGGMVDFRCTLTL 513

  Fly   516 SLFFKAYLAISLKLSKSGITSSDALPSEERSGA--ETFHTPVL-------KSAQLFERVCSDQPI 571
            |.|||.||.:..||.:..:        |::.|.  .||.:..|       ...|||:.|...|..
Human   514 SFFFKFYLTVLQKLGQENL--------EDKCGKLDPTFASATLLFQKDPPADVQLFQEVPKGQSE 570

  Fly   572 CDPIGRPKVHAAALKQATGEAIYTDDIPRMDGEVYLAFVLSTKPRAKITKLDASEALALDGVHQF 636
            .|.:|||..|.||..||:|||:|.|||||.:.|:.|..|.||:..|||..:|.|||..:.|   |
Human   571 EDMVGRPLPHLAADMQASGEAVYCDDIPRYENELSLRLVTSTRAHAKIKSIDTSEAKKVPG---F 632

  Fly   637 FCY--KDLTEHENEVGPVFHDEHVFAAGEVHCYGQIVGAIAADNKALAQRAARLVKVEYEELSPV 699
            .|:  .|.....|..| :.:||.|||..:|.|.|.|:||:.||.....||||:.||:.|||| |.
Human   633 VCFISADDVPGSNITG-ICNDETVFAKDKVTCVGHIIGAVVADTPEHTQRAAQGVKITYEEL-PA 695

  Fly   700 IVTIEQAIEHKSYF-PDYPRFVTKGNVEEALAQADHTFEGTCRMGGQEHFYLETHAALAVPR-DS 762
            |:|||.||::.|:: |:..  :.||::::..::||:...|...:|||||||||||..:|||: ::
Human   696 IITIEDAIKNNSFYGPELK--IEKGDLKKGFSEADNVVSGEIYIGGQEHFYLETHCTIAVPKGEA 758

  Fly   763 DELELFCSTQHPSEVQKLVAHVTALPAHRVVCRAKRLGGGFGGKESRGISVALPVALAAYRMGRP 827
            .|:|||.|||:..:.|..||.:..:||:|:|.|.||:||||||||:|...|:..||||||:.|||
Human   759 GEMELFVSTQNTMKTQSFVAKMLGVPANRIVVRVKRMGGGFGGKETRSTVVSTAVALAAYKTGRP 823

  Fly   828 VRCMLDRDEDMLITGTRHPFLFKYKVGFTKEGLITACDIECYNNAGWSMDLSFSVLERAMFHFEN 892
            |||||||||||||||.|||||.:|||||.|.|.:.|.:::.::|.|.:.|||.|::|||:||.:|
Human   824 VRCMLDRDEDMLITGGRHPFLARYKVGFMKTGTVVALEVDHFSNVGNTQDLSQSIMERALFHMDN 888

  Fly   893 CYRIPNVRVGGWVCKTNLPSNTAFRGFGGPQGMYAGEHIIRDVARIVGRDVVDVMRLNFYKTGDY 957
            ||:|||:|..|.:||||||||||||||||||||...|..:.:||...|....:|.|.|.||.||.
Human   889 CYKIPNIRGTGRLCKTNLPSNTAFRGFGGPQGMLIAECWMSEVAVTCGMPAEEVRRKNLYKEGDL 953

  Fly   958 THYHQQLEHFPIERCLEDCLKQSRYDEKRQEIARFNRENRWRKRGMAVVPTKYGIAFGVMHLNQA 1022
            ||::|:||.|.:.||.|:||..|:|..::.|:.:||:||.|:|||:.::|||:||:|.|..||||
Human   954 THFNQKLEGFTLPRCWEECLASSQYHARKSEVDKFNKENCWKKRGLCIIPTKFGISFTVPFLNQA 1018

  Fly  1023 GSLINIYGDGSVLLSHGGVEIGQGLNTKMIQCAARALGIPSELIHISETATDKVPNTSPTAASVG 1087
            |:|:::|.||||||:|||.|:||||:|||:|.|:|||.||:..|:||||:|:.|||||||||||.
Human  1019 GALLHVYTDGSVLLTHGGTEMGQGLHTKMVQVASRALKIPTSKIYISETSTNTVPNTSPTAASVS 1083

  Fly  1088 SDLNGMAVLDACEKLNKRLAPIKEALPGGTWKEWINKAYFDRVSLSATGFYAMPGIGYHPETNPN 1152
            :||||.||..||:.:.|||.|.|:..|.|:|::|:..||.|.|||||||||..|.:||..||| :
Human  1084 ADLNGQAVYAACQTILKRLEPYKKKNPSGSWEDWVTAAYMDTVSLSATGFYRTPNLGYSFETN-S 1147

  Fly  1153 ARTYSYYTNGVGVTVVEIDCLTGDHQVLSTDIVMDIGSSLNPAIDIGQIEGAFMQGYGLFTLEEL 1217
            ...:.|::.||..:.||||||||||:.|.||||||:||||||||||||:||||:||.||||||||
Human  1148 GNPFHYFSYGVACSEVEIDCLTGDHKNLRTDIVMDVGSSLNPAIDIGQVEGAFVQGLGLFTLEEL 1212

  Fly  1218 MYSPQGMLYSRGPGMYKLPGFADIPGEFNVSLLTGAPNPRAVYSSKAVGEPPLFIGSSAFFAIKE 1282
            .|||:|.|::|||..||:|.|..||.||.||||...||.:|:|:||||||||||:.:|.|||||:
Human  1213 HYSPEGSLHTRGPSTYKIPAFGSIPIEFRVSLLRDCPNKKAIYASKAVGEPPLFLAASIFFAIKD 1277

  Fly  1283 AIAAAREDQGLSGD-----FPLEAPSTSARIRIACQDKFTELLEIPEPGSFTPWNI 1333
            ||.|||...  :|:     |.|::|:|..:||.||.||||.|.....|.:..||::
Human  1278 AIRAARAQH--TGNNVKELFRLDSPATPEKIRNACVDKFTTLCVTGVPENCKPWSV 1331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ry	NP_524337.1	Fer2	8..78	CDD:278537	47/69 (68%)
		PLN02906	25..1317	CDD:215491	686/1314 (52%)
		Fer2_2	87..158	CDD:280048	59/70 (84%)
		FAD_binding_5	231..411	CDD:279309	83/179 (46%)
		CO_deh_flav_C	422..525	CDD:281449	44/102 (43%)
		Ald_Xan_dh_C	589..696	CDD:279635	48/108 (44%)
		Ald_Xan_dh_C2	716..1242	CDD:280834	303/526 (58%)
XDH	NP_000370.2	PLN02906	23..1319	CDD:215491	690/1320 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147665
Domainoid	1	1.000	639	1.000	Domainoid score	I163
eggNOG	1	0.900	-	-		E1_COG4631
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H324
Inparanoid	1	1.050	1362	1.000	Inparanoid score	I131
Isobase	1	0.950	-	0	Normalized mean entropy	S3132
OMA	1	1.010	-	-		QHG54386
OrthoDB	1	1.010	-	-		D48717at2759
OrthoFinder	1	1.000	-	-		FOG0000201
OrthoInspector	1	1.000	-	-		oto88338
orthoMCL	1	0.900	-	-		OOG6_100184
Panther	1	1.100	-	-	LDO	PTHR11908
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3503
SonicParanoid	1	1.000	-	-		X518
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	16	15.790