DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ry and aox6

DIOPT Version :9

Sequence 1:	NP_524337.1	Gene:	ry / 41605	FlyBaseID:	FBgn0003308	Length:	1335	Species:	Drosophila melanogaster
Sequence 2:	NP_001265746.1	Gene:	aox6 / 570457	ZFINID:	ZDB-GENE-050208-742	Length:	1338	Species:	Danio rerio

Alignment Length:	1348	Identity:	635/1348 - (47%)
Similarity:	879/1348 - (65%)	Gaps:	39/1348 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 NSVLVFFVNGKKVTEVSPDPECTLLTFLREKLRLCGTKLGCAEGGCGACTVMVSRLDRRANKIRH 67
            |..|:|:|||||:.|.:||||..||.:||:||||.|||..|..|||||||:||||.|.:...|.|
Zfish     7 NDGLIFYVNGKKIVEKNPDPETMLLPYLRKKLRLTGTKYSCGGGGCGACTIMVSRYDPQTKSISH 71

  Fly    68 LAVNACLTPVCSMHGCAVTTVEGIGSTKTRLHPVQERLAKAHGSQCGFCTPGIVMSMYALLRNAE 132
            |:||.||.|:|.:||.|||||||||:|||:|||||||:||||||||||||||:|||||.||||..
Zfish    72 LSVNGCLFPICHLHGAAVTTVEGIGNTKTKLHPVQERIAKAHGSQCGFCTPGMVMSMYTLLRNNP 136

  Fly   133 QPSMRDLEVAFQGNLCRCTGYRPILEGYKTFTKEFACGMGEKCCKVSGKGC------GTDAETDD 191
            .|::.|:.....||||||||||||::||:||.:      .|.||.::|..|      |:......
Zfish   137 HPTLDDITECLAGNLCRCTGYRPIIDGYRTFCE------SENCCLLNGSTCNVLNGNGSAENGHA 195

  Fly   192 KLFERSEFQPLDPSQEPIFPPEL-QLSDAFDSQSLIFSSDRVTWYRPTNLEELLQLKAKHPAAKL 255
            :||.:.:..||||||:.|||||| ::::..|.....|..:|:||..|.:|:|||||||.:|.|.|
Zfish   196 ELFSKDDLLPLDPSQDLIFPPELMRMAEDKDQSIQRFCGERMTWISPGSLDELLQLKADYPQAPL 260

  Fly   256 VVGNTEVGVEVKFKHFLYPHLINPTQVKELLEIKENQDGIYFGAAVSLMEIDALLRQRIEQLPES 320
            |:|||.:|:::|||...:|.:|:||:|.||.::....:|:..||..|:.::.::|.:.|...|..
Zfish   261 VMGNTTIGLDMKFKGIFHPIIISPTRVPELFKVNHRSEGVCVGAGCSMSDLKSVLEKTINDFPPE 325

  Fly   321 ETRLFQCTVDMLHYFAGKQIRNVACLGGNIMTGSPISDMNPVLSAAGAQLEVASFVDGKLQKRSV 385
            .|..|:..:..::...|:||||||.|||||.:..|.||:.||| |||....||...||   :|.:
Zfish   326 NTHTFRALLQQINLVGGQQIRNVATLGGNIASAYPNSDLTPVL-AAGRCTLVALSKDG---RRRL 386

  Fly   386 HMGTGFFTGYRRNVIEAHEVLLGIHFRKTTPDQYIVAFKQARRRDDDIAIVNAAINVRFEEKSNI 450
            .:...||.|:.:.:::..|:||.:....|..::.:.||:...|:::.:|.:||.:.|...:.||:
Zfish   387 PIDKDFFLGFAKTILKPEEILLSVFIPATRQNEIVHAFRHVPRKENALATLNAGMRVWLNDNSNV 451

  Fly   451 VAEISMAFGGMAPTTVLAPRTSQLMVGQEWSHQLVERVAESLCTELPLAASAPGGMIAYRRALVV 515
            |.|||:.:||:..|.:.|....|.:||:.|....:.....:|..::.|..:||||.:.:||:|.:
Zfish   452 VKEISIYYGGVGATILSADHACQKIVGRPWEEATLNDAYSALFDDVKLDPAAPGGKVDFRRSLTL 516

  Fly   516 SLFFKAYLAISLKLSKSGITSSDALPSEERSGAETFHTPVLKSAQLFERVCSDQPICDPIGRPKV 580
            ||.||.:|.|...|.:..:...: :|.|.:|..:.....:|...|.|:.|..||...|.:|||.:
Zfish   517 SLLFKFHLLILQYLKEKDVIQME-VPQEMQSAIQPLPKRILPGYQEFQNVLEDQSAQDLVGRPMM 580

  Fly   581 HAAALKQATGEAIYTDDIPRMDGEVYLAFVLSTKPRAKITKLDASEALALDGVHQFFCYKDLTEH 645
            |.:||.||||||:|.||:|..|||:.||.|.|:|..||||.:|.||||.|.||......||:.
Zfish   581 HRSALSQATGEAVYCDDLPYTDGELVLAIVTSSKAHAKITHIDFSEALKLPGVVDVITAKDIP-- 643

  Fly   646 ENEVGPVF-----HDEHVFAAGEVHCYGQIVGAIAADNKALAQRAARLVKVEYEELSPVIVTIEQ 705
                |..|     :||.:.|..||.|.||::.|:.||:||.|:|.|..|||.||:|...|.|:|:
Zfish   644 ----GKKFRTFTGYDEELLAEDEVSCVGQMICAVVADSKAHAKRGAAAVKVSYEDLQDCIFTLEE 704

  Fly   706 AIEHKSYFPDYP-RFVTKGNVEEALAQADHTFEGTCRMGGQEHFYLETHAALAVP-RDSDELELF 768
            |||.:|:|  .| |.:.:|:||:.|..|:..:||..|:|||||||:||.:.|.|| .:..|::::
Zfish   705 AIEKESFF--LPRRQIERGDVEKGLRDAEQVYEGEIRIGGQEHFYMETQSFLVVPVGEEKEMKVY 767

  Fly   769 CSTQHPSEVQKLVAHVTALPAHRVVCRAKRLGGGFGGKESRGISVALPVALAAYRMGRPVRCMLD 833
            .|||||:..|:.||....:|::||.|..|||||.||||.::...:|...|.||::.|.||||:|:
Zfish   768 LSTQHPTYTQEAVAETLGIPSNRVTCHVKRLGGAFGGKVTKTAILASITAAAAWKTGLPVRCVLE 832

  Fly   834 RDEDMLITGTRHPFLFKYKVGFTKEGLITACDIECYNNAGWSMDLSFSVLERAMFHFENCYRIPN 898
            |.|||||||.|||...||||||.|.|.|||.|.:.|.|:|..:|.|..|.|:.:.|.:|.|.|||
Zfish   833 RGEDMLITGGRHPVWGKYKVGFMKNGRITAADFQYYANSGNKVDESVLVAEKILLHLDNAYNIPN 897

  Fly   899 VRVGGWVCKTNLPSNTAFRGFGGPQGMYAGEHIIRDVARIVGRDVVDVMRLNFYKTGDYTHYHQQ 963
            :|.....|:|||||||||||||.||.|...|.:|.|||..:||...::..:|.||....|||..:
Zfish   898 LRGRSAACRTNLPSNTAFRGFGVPQCMLVIESMIDDVALQLGRLPEEIREMNMYKQVSLTHYKME 962

  Fly   964 LEHFPIERCLEDCLKQSRYDEKRQEIARFNRENRWRKRGMAVVPTKYGIAFGVMHLNQAGSLINI 1028
            .:...:.||.::|:::|.:..:|:.|..||::|:::|||::::|.||||.|....||||.:|::|
Zfish   963 FDPENLVRCWKECMEKSDFSHRRKAIDLFNQQNQFKKRGISIIPIKYGIGFAEGFLNQAAALVHI 1027

  Fly  1029 YGDGSVLLSHGGVEIGQGLNTKMIQCAARALGIPSELIHISETATDKVPNTSPTAASVGSDLNGM 1093
            |.|||||:||||.|:||||:||:.|.|:|.|.||:.|||||||:|..||||.|:|||.|:|.|||
Zfish  1028 YKDGSVLVSHGGAEMGQGLHTKIQQVASRELNIPASLIHISETSTQCVPNTCPSAASFGTDANGM 1092

  Fly  1094 AVLDACEKLNKRLAPIKEALPGGTWKEWINKAYFDRVSLSATGFYAMPGIGYHPETNPNARTYSY 1158
            ||.|||:.|..||.|:::..|.|||:.||.||:.:::||||||:|....:....| ....|.|:|
Zfish  1093 AVQDACQILYNRLEPVRKKDPKGTWQNWIMKAFLEKISLSATGYYRGHDLDMDWE-KQEGRPYAY 1156

  Fly  1159 YTNGVGVTVVEIDCLTGDHQVLSTDIVMDIGSSLNPAIDIGQIEGAFMQGYGLFTLEELMYSPQG 1223
            :|..|..:.||:|||||:::.|.||||:|||.|:||:||||||||||.||.||:|:|||.|||.|
Zfish  1157 FTYAVCCSEVELDCLTGEYRTLRTDIVVDIGRSINPSIDIGQIEGAFTQGLGLYTMEELKYSPSG 1221

  Fly  1224 MLYSRGPGMYKLPGFADIPGEFNVSLLTGAPNPRAVYSSKAVGEPPLFIGSSAFFAIKEAIAAAR 1288
            :||:||||.||:|...|:|..|||.||.|:.||.|:||||.:|||.||:|||.|||||:|:.|||
Zfish  1222 VLYTRGPGQYKIPAVCDVPLNFNVYLLAGSSNPHAIYSSKGIGEPTLFLGSSVFFAIKDAVTAAR 1286

  Fly  1289 EDQGLSGDFPLEAPSTSARIRIACQDKFTELL-----EIPEPGSFTPW 1331
            :|.||:|.|.|.:|:|..|..:||..:||.::     .:...|...||
Zfish  1287 KDAGLTGPFQLNSPATPERACLACATRFTNMVVAQNEPVSTSGPARPW 1334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ry	NP_524337.1	Fer2	8..78	CDD:278537	43/69 (62%)
		PLN02906	25..1317	CDD:215491	617/1305 (47%)
		Fer2_2	87..158	CDD:280048	53/70 (76%)
		FAD_binding_5	231..411	CDD:279309	71/179 (40%)
		CO_deh_flav_C	422..525	CDD:281449	35/102 (34%)
		Ald_Xan_dh_C	589..696	CDD:279635	53/111 (48%)
		Ald_Xan_dh_C2	716..1242	CDD:280834	269/527 (51%)
aox6	NP_001265746.1	mam_aldehyde_ox	10..1338	CDD:132014	634/1345 (47%)
		Fer2_2	91..162	CDD:280048	53/70 (76%)
		FAD_binding_5	235..414	CDD:279309	71/182 (39%)
		CO_deh_flav_C	422..524	CDD:281449	34/101 (34%)
		Ald_Xan_dh_C	589..695	CDD:214971	53/111 (48%)
		Ald_Xan_dh_C2	708..1240	CDD:280834	271/534 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581490
Domainoid	1	1.000	105	1.000	Domainoid score	I6574
eggNOG	1	0.900	-	-		E1_COG4631
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54386
OrthoDB	1	1.010	-	-		D48717at2759
OrthoFinder	1	1.000	-	-		FOG0000201
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100184
Panther	1	1.100	-	-	O	PTHR11908
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X518
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.760