Protein Alignment ry and Aox1

DIOPT Version :10

• Sequence 1: NP_524337.1
• Gene: ry / 41605
• FlyBaseID: FBgn0003308
• Length: 1335
• Species: Drosophila melanogaster
• Sequence 2: NP_062236.3
• Gene: Aox1 / 54349
• RGDID: 620528
• Length: 1333
• Species: Rattus norvegicus
• Alignment Length: 1342
• Identity: 611/1342 - (45%)
• Similarity: 866/1342 - (64%)
• Gaps: 30/1342 - (2%)

  Fly     6 LVFFVNGKKVTEVSPDPECTLLTFLREKLRLCGTKLGCAEGGCGACTVMVSRLDRRANKIRHLAV 70
            |:|:|||:||.|.:.|||..||.:||:.|||.|||.||..|||||||||:||.:.....|||..|
  Rat     6 LLFYVNGQKVVENNVDPEMMLLPYLRKNLRLTGTKYGCGGGGCGACTVMISRYNPSTKSIRHHPV 70

  Fly    71 NACLTPVCSMHGCAVTTVEGIGSTKTRLHPVQERLAKAHGSQCGFCTPGIVMSMYALLRNAEQPS 135
            ||||||:||::|.|||||||||:|:|||||||||:||.||:||||||||:||||||||||..:||
  Rat    71 NACLTPICSLYGTAVTTVEGIGNTRTRLHPVQERIAKCHGTQCGFCTPGMVMSMYALLRNHPEPS 135

  Fly   136 MRDLEVAFQGNLCRCTGYRPILEGYKTFTKEFACGMGEK---CCKVSGKGCGTD----AETDDKL 193
            :..|..|..||||||||||||::..|||.:...|...::   ||...|.....:    .||..:|
  Rat   136 LDQLTDALGGNLCRCTGYRPIIDACKTFCRASGCCESKENGVCCLDQGINGSAEFQEGDETSPEL 200

  Fly   194 FERSEFQPLDPSQEPIFPPEL-QLSDAFDSQSLIFSSDRVTWYRPTNLEELLQLKAKHPAAKLVV 257
            |...|||||||:||.|||||| ::::....::.:|.|:|:||..|..||||::.|.|:|.|.:|:
  Rat   201 FSEKEFQPLDPTQELIFPPELMRIAEKQPPKTRVFYSNRMTWISPVTLEELVEAKFKYPGAPIVM 265

  Fly   258 GNTEVGVEVKFKHFLYPHLINPTQVKELLEIKENQDGIYFGAAVSLMEIDALLRQRIEQLPESET 322
            |.|.||.|||||...:|.:|:|.:::||..|.:..||:..||.:||.::..:|...:::|||..|
  Rat   266 GYTSVGPEVKFKGVFHPIIISPDRIEELSIINQTGDGLTLGAGLSLDQVKDILTDVVQKLPEETT 330

  Fly   323 RLFQCTVDMLHYFAGKQIRNVACLGGNIMTGSPISDMNPVLSAAGAQLEVASFVDGKLQKRSVHM 387
            :.::..:..|...||.||||:|.|||:|::....||:||:|:.....|.:.| .||   ||.:.:
  Rat   331 QTYRALLKHLRTLAGSQIRNMASLGGHIVSRHLDSDLNPLLAVGNCTLNLLS-KDG---KRQIPL 391

  Fly   388 GTGFFTGYRRNVIEAHEVLLGIHFRKTTPDQYIVAFKQARRRDDDIAIVNAAINVRFEEKSNIVA 452
            ...|......:.::..|||:.::...:...:::.||:||:|:.:.:||||:.:.|.|.|...::.
  Rat   392 SEQFLRKCPDSDLKPQEVLVSVNIPCSRKWEFVSAFRQAQRQQNALAIVNSGMRVLFREGGGVIK 456

  Fly   453 EISMAFGGMAPTTVLAPRTSQLMVGQEWSHQLVERVAESLCTELPLAASAPGGMIAYRRALVVSL 517
            |:|:.:||:.|||:.|..:.|.::|:.|:.::::.....:..|:.||.|||||.:.::|.|::|.
  Rat   457 ELSILYGGVGPTTIGAKNSCQKLIGRPWNEEMLDTACRLVLDEVTLAGSAPGGKVEFKRTLIISF 521

  Fly   518 FFKAYLAISLKLSKSGITSSDALPSEERSGAETFHTPVLKSAQLFERVCSDQPICDPIGRPKVHA 582
            .||.||.:...|.:.......:|.:...|..|..|:.........:.|.|.|...||||||.:|.
  Rat   522 LFKFYLEVLQGLKREDPGHYPSLTNNYESALEDLHSKHHWRTLTHQNVDSMQLPQDPIGRPIMHL 586

  Fly   583 AALKQATGEAIYTDDIPRMDGEVYLAFVLSTKPRAKITKLDASEALALDGVHQFFCYKDLTEHEN 647
            :.:|.|||||||.||:|.:|.|::|.||.|::..|||..:|.||||:|.||...     :|....
  Rat   587 SGIKHATGEAIYCDDMPAVDRELFLTFVTSSRAHAKIVSIDLSEALSLPGVVDI-----ITADHL 646

  Fly   648 EVGPVFHDEHVFAAGEVHCYGQIVGAIAADNKALAQRAARLVKVEYEELSPVIVTIEQAIEHKSY 712
            :....|..|.:.|..:|||.||:|.|:.||::..|::||:.|||.|.:|.|:|:|||:||:|||:
  Rat   647 QDTTTFGTETLLATDKVHCVGQLVCAVIADSETRAKQAAKHVKVVYRDLEPLILTIEEAIQHKSF 711

  Fly   713 FPDYPRFVTKGNVEEALAQADHTFEGTCRMGGQEHFYLETHAALAVPRDSD-ELELFCSTQHPSE 776
            | :..|.:..|||:||...||...||...:|||||||:||.:.|.||:..| |::::.|||.|..
  Rat   712 F-ESERKLECGNVDEAFKIADQILEGEIHIGGQEHFYMETQSMLVVPKGEDGEIDIYVSTQFPKH 775

  Fly   777 VQKLVAHVTALPAHRVVCRAKRLGGGFGGKESRGISVALPVALAAYRMGRPVRCMLDRDEDMLIT 841
            :|.:||....|..::|:|..:|:||.||||..:...:|...|.||.:.||.|||.|:|.||||||
  Rat   776 IQDIVAATLKLSVNKVMCHVRRVGGAFGGKVGKTSIMAAITAFAASKHGRAVRCTLERGEDMLIT 840

  Fly   842 GTRHPFLFKYKVGFTKEGLITACDIECYNNAGWSMDLSFSVLERAMFHFENCYRIPNVRVGGWVC 906
            |.|||:|.||||||.::|.|.|.|:|.|.|.|.|:|.|..|:|..:...:|.|:.||:|..||.|
  Rat   841 GGRHPYLGKYKVGFMRDGRIVALDVEHYCNGGSSLDESLWVIEMGLLKMDNAYKFPNLRCRGWAC 905

  Fly   907 KTNLPSNTAFRGFGGPQGMYAGEHIIRDVARIVGRDVVDVMRLNFYKTGDYTHYHQQLEHFPIER 971
            :||||||||.||||.||.....|..:.:||...|.....|..:|.||..|.|||.|:.....:..
  Rat   906 RTNLPSNTALRGFGFPQAGLVTEACVTEVAIRCGLSPEQVRTINMYKQIDNTHYKQEFSAKTLFE 970

  Fly   972 CLEDCLKQSRYDEKRQEIARFNRENRWRKRGMAVVPTKYGIAFGVMHLNQAGSLINIYGDGSVLL 1036
            |..:|:.:..|.|::..:.:||.||.|:||||||:|.|:.:..|.:.:.||.:|::||.|||.|:
  Rat   971 CWRECMAKCSYSERKTAVGKFNAENSWKKRGMAVIPLKFPVGVGSVAMGQAAALVHIYLDGSALV 1035

  Fly  1037 SHGGVEIGQGLNTKMIQCAARALGIPSELIHISETATDKVPNTSPTAASVGSDLNGMAVLDACEK 1101
            ||||:|:|||::|||||..:|.|.:|...:|:..|:|:.||||:.:..||.:||||:||.|||:.
  Rat  1036 SHGGIEMGQGVHTKMIQVVSRELKMPMSSVHLRGTSTETVPNTNASGGSVVADLNGLAVKDACQT 1100

  Fly  1102 LNKRLAPIKEALPGGTWKEWINKAYFDRVSLSATGFYAMPGIGYHPETNPN-----ARTYSYYTN 1161
            |.|||.||....|.||||:|...|:...|||||.|::.    ||  |:|.|     ...:.|:..
  Rat  1101 LLKRLEPIISKNPQGTWKDWAQTAFDQSVSLSAVGYFR----GY--ESNINWEKGEGHPFEYFVY 1159

  Fly  1162 GVGVTVVEIDCLTGDHQVLSTDIVMDIGSSLNPAIDIGQIEGAFMQGYGLFTLEELMYSPQGMLY 1226
            |...:.||||||||||:.:.||||||:|.|:|||:||||:||||:||.||:|:|||.|||||:||
  Rat  1160 GAACSEVEIDCLTGDHKNIRTDIVMDVGHSINPALDIGQVEGAFIQGMGLYTIEELSYSPQGILY 1224

  Fly  1227 SRGPGMYKLPGFADIPGEFNVSLLTGAPNPRAVYSSKAVGEPPLFIGSSAFFAIKEAIAAAREDQ 1291
            ||||..||:|...|||.|.::|.|..:.:...:||||.:||..:|:|.|.||||.:|:.|||:::
  Rat  1225 SRGPNQYKIPAICDIPTEMHISFLPPSEHSNTLYSSKGLGESGVFLGCSVFFAIHDAVRAARQER 1289

  Fly  1292 GLSGDFPLEAPSTSARIRIACQDKFTELLEIPEPGSFTPWNI 1333
            |:||.:.|.:|.|..:||:||:||||:::...||||:.||||
  Rat  1290 GISGPWKLTSPLTPEKIRMACEDKFTKMIPRDEPGSYVPWNI 1331

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ry	NP_524337.1	PLN02906	25..1317	CDD:215491	590/1305 (45%)
Aox1	NP_062236.3	mam_aldehyde_ox	4..1333	CDD:132014	611/1342 (46%)