DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ry and AOX2

DIOPT Version :9

Sequence 1:	NP_524337.1	Gene:	ry / 41605	FlyBaseID:	FBgn0003308	Length:	1335	Species:	Drosophila melanogaster
Sequence 2:	NP_732047.2	Gene:	AOX2 / 41895	FlyBaseID:	FBgn0038348	Length:	1264	Species:	Drosophila melanogaster

Alignment Length:	1356	Identity:	417/1356 - (30%)
Similarity:	631/1356 - (46%)	Gaps:	172/1356 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FFVNG--KKVTEVSPDPECTLLTFLREKLRLCGTKLGCAEGGCGACTVMVSRLDRRANKIRHLAV 70
            |.|||  .:|......|:.||.|||||.|.|..||..|.|||||:|..::.|......:::..|.
  Fly     5 FNVNGFPYEVQAADYPPDTTLNTFLREHLHLTATKYMCLEGGCGSCVCVIRRRHPVTQEVQSRAA 69

  Fly    71 NACLTPVCSMHGCAVTTVEGIGSTKTRLHPVQERLAKAHGSQCGFCTPGIVMSMYALL-RNAEQP 134
            |:|||.:.:.....:.|.||:|:..:..||:|:|:|:.:|:|||:|:||.||:||.|| ::..|.
  Fly    70 NSCLTLLNTCDDAEIMTDEGLGNQLSGYHPIQKRVAQMNGTQCGYCSPGFVMNMYGLLEQHRGQV 134

  Fly   135 SMRDLEVAFQGNLCRCTGYRPILEGYKTFTKEFACGMG----------EKCCKVSGKGCGTDAET 189
            ||..:|.||.|||||||||||||:..|:|..:....:.          |..|..:|:.|......
  Fly   135 SMSQVEDAFGGNLCRCTGYRPILDAMKSFAVDSNVEVPAESVDIEDSFELLCPRTGQSCKGSCSR 199

  Fly   190 DDKLFERSEFQPLDPSQEPIFPPELQLSDAFDSQSLIFSSDRVTWYRPTNLEEL---LQLKAKHP 251
                                 ||   |.|..|||          ||.|..|.||   |...|...
  Fly   200 ---------------------PP---LRDHGDSQ----------WYWPKTLTELFGALSQVANGE 230

  Fly   252 AAKLVVGNTEVGVEVKFKHFLYP----HLINPTQVKELLEIKENQDGIYFGAAVSL---MEIDAL 309
            ...||.|||..||      :..|    |.|:...|.||.:.....|.:..|..|:|   |::..|
  Fly   231 LYMLVAGNTAHGV------YRRPRDIRHFIDVNMVPELRQYSIETDHLLLGGNVTLTDAMQVFLL 289

  Fly   310 LRQRIEQLPESE--TRLFQCTVDMLHY--FAGKQIRNVACLGGNIMTGSPISDMNPVLSAAGAQL 370
            ..:|    |..|  .:|:|      |:  .|...:||...|.|||.......:....:......|
  Fly   290 AAKR----PGFEYCAQLWQ------HFNLIANVPVRNNGTLAGNINIKKQHFEFPSDVFITFEAL 344

  Fly   371 EVASFV-DGKLQKRSVHMGTGFFTGYRRNVIEAHEVLLGIHFRKTTP-DQYIV-AFKQARRRDDD 432
            :|...| |....:|.:::.|  :.|...:     :::||....|..| |:::. ::|...|..:.
  Fly   345 DVHVLVYDNPSTQRVMNLLT--YLGDTTS-----KLVLGGFILKAYPKDRFLFRSYKILPRAQNV 402

  Fly   433 IAIVNAAINVRFEE-KSNIVAEISMAFGGMAPTTVLAPRTSQLMVGQE-WSHQLVERVAESLCTE 495
            .|.|||...:.::: :..||....:.||.:.|..:...:..||:.|:: :....|.::.:.|...
  Fly   403 HAYVNAGFLIEWQDIQHRIVHSARICFGNIRPDYIHDDQVEQLLPGRDLYDPATVAQIFQELPAS 467

  Fly   496 LPLAASAPGGMIAYRRALVVSLFFKAYLAISLKLSKSGITSSDALPSEERSGAETFHTPVLKSAQ 560
            |......|.....||:.|..||.:|..||.:.|         :.:....|:|......|:...:|
  Fly   468 LQPEERPPEASPEYRQMLACSLLYKFLLATAPK---------ERVRERFRTGGLLLERPLSSGSQ 523

  Fly   561 LFERVCSDQPICDPIGRPKVHAAALKQATGEAIYTDDIPRMDGEVYLAFVLSTKPRAKITKLDAS 625
            .||.:..:.|:..|:.:    ...|.|.:|||.|.:|:......|:.|||.:.:..|.|.::|.|
  Fly   524 SFETIKKNYPVTQPVQK----LEGLIQCSGEATYMNDLLTTSNAVHCAFVTAKRVGATIEQIDPS 584

  Fly   626 EALALDGVHQFFCYKDLTEHE-----NEVGPVFHDEHVFAAGEVHCYGQIVGAIAADNKALAQRA 685
            .||...||..|:..:|:....     |::.|  ..:.||.||.|..:.|.:|.|||.....|..|
  Fly   585 AALQCKGVVAFYSAEDIPGSNNFVLVNQLTP--EVDEVFVAGRVKYFDQPLGVIAALTHDAAVYA 647

  Fly   686 ARLVKVEY-EELSPVIVTIEQAIEHKSYFPDYPRFVT--KGNVE----EALAQADHTFEGTCRMG 743
            |.||.|.| .:...:..|:.|.:..|    ...|.|:  |..||    ..||..|....|...:.
  Fly   648 ATLVVVTYARDQRKIFTTMNQVLAEK----QTDRIVSTKKDTVEPLKLPPLAPGDVLGRGILELA 708

  Fly   744 GQEHFYLETHAALAVPRDSDELELFCSTQHPSEVQKLVAHVTALPAHRVVCRAKRLGGGFGGKES 808
            .|.||.:|....:.||.| :.|:::|:||.....|..:||:..:..:.:..:.:|:||.:|.|.:
  Fly   709 SQYHFTMEPQTTIVVPLD-NILQVYCATQWMDATQGAIAHMLKVSVNSIQLQVRRVGGAYGAKVT 772

  Fly   809 RGISVALPVALAAYRMGRPVRCMLDRDEDMLITGTRHPFLFKYKVGFTKEGLITACDIECYNNAG 873
            ||..||...||.|.::.||.|.:...:..|...|.|......|:......|.|.......|.::|
  Fly   773 RGNIVACATALVASKLRRPARFVQTIESMMETIGKRWACRSDYEFRARANGSIIMLSNNYYEDSG 837

  Fly   874 WSMD------LSFSVLERAMFHFENCYRI--PNVRVGGWVCKTNLPSNTAFRGFGGPQGMYAGEH 930
            .:::      |:..:|       .|.|.:  .|.|..|...:|:.||:|..|..|..:|:...|.
  Fly   838 CNLNENVVDFLTLPIL-------RNVYNLTDANYRTQGSAIRTDAPSSTWCRAPGSAEGIAMTET 895

  Fly   931 IIRDVARIVGRDVVDVMRLNFYKTGDYTHYHQQLEHFPIERCLEDCLKQSRYDEKRQEIARFNRE 995
            .:..:|.....|..||..:|. :.|:           .:.:.|...|..:.|.::|.:|..||.:
  Fly   896 ALEHIAFTCQLDPADVRLVNL-QPGN-----------KMVQLLPKFLASTEYHKRRDQINLFNSQ 948

  Fly   996 NRWRKRGMAVV----PTKYGIAFGVMHLNQAGSLINIYGDGSVLLSHGGVEIGQGLNTKMIQCAA 1056
            |||||||:.:.    |....:||     |...::...:.||||::||||:|||||:|||..|.||
  Fly   949 NRWRKRGLGLALMSFPLNTTVAF-----NYPVTVAIYHEDGSVVISHGGIEIGQGVNTKAAQVAA 1008

  Fly  1057 RALGIPSELIHISETATDKVPNTSPTAASVGSDLNGMAVLDACEKLNKRLAPIKEAL-PGGTWKE 1120
            ..||:|.:.:.:..:.|....|:..||.|:.|::.|:||..||:.|||||||:||.| |..:|.:
  Fly  1009 FVLGVPLDQVRVEASNTVNGANSMLTANSMTSEMIGLAVRKACDTLNKRLAPVKERLGPRASWVQ 1073

  Fly  1121 WINKAYFDRVSLSATGFYAMPGIGYHPETNPNARTYSYYTNGVGVTVVEIDCLTGDHQVLSTDIV 1185
            .:..|:...|.|.||..|.:..|       ||     |...|:.:|.:|:|.|||:|.:...||:
  Fly  1074 VLQAAFLQSVFLIATESYRLGDI-------PN-----YNIFGLSLTELELDILTGNHLIRRVDIL 1126

  Fly  1186 MDIGSSLNPAIDIGQIEGAFMQGYGLFTLEELMYSPQ-GMLYSRGPGMYKLPGFADIPGEFNVSL 1249
            .|.|.||:|.||:||:||||:.|.|.:..|:|:|..| |.:.:.....|..||..|||.:|.:.|
  Fly  1127 EDAGESLSPHIDVGQVEGAFVMGLGYYLTEQLVYDRQTGQILTNRTWNYHPPGAKDIPIDFRIEL 1191

  Fly  1250 LTGAPNPRAVYSSKAVGEPPLFIGSSAFFAIKEAIAAAREDQGLSGDF-PLEAPST 1304
            |..:|||.....|||.|||.|.:...|.||::.||.:||.|.||..:: .|.||:|
  Fly  1192 LQKSPNPVGFMRSKATGEPALCLAVGALFAMQHAIQSARNDAGLPREWVRLGAPTT 1247

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ry	NP_524337.1	Fer2	8..78	CDD:278537	30/71 (42%)
		PLN02906	25..1317	CDD:215491	411/1337 (31%)
		Fer2_2	87..158	CDD:280048	40/71 (56%)
		FAD_binding_5	231..411	CDD:279309	49/194 (25%)
		CO_deh_flav_C	422..525	CDD:281449	25/104 (24%)
		Ald_Xan_dh_C	589..696	CDD:279635	38/112 (34%)
		Ald_Xan_dh_C2	716..1242	CDD:280834	174/545 (32%)
AOX2	NP_732047.2	fer2	3..84	CDD:238126	30/78 (38%)
		PLN02906	24..1251	CDD:215491	411/1337 (31%)
		Fer2_2	86..159	CDD:280048	41/72 (57%)
		FAD_binding_4	206..366	CDD:303082	49/187 (26%)
		CO_deh_flav_C	391..497	CDD:281449	25/105 (24%)
		Ald_Xan_dh_C	548..655	CDD:214971	37/108 (34%)
		Ald_Xan_dh_C2	702..1184	CDD:280834	166/518 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45459129
Domainoid	1	1.000	150	1.000	Domainoid score	I192
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	195	1.000	Inparanoid score	I167
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D19024at33392
OrthoFinder	1	1.000	-	-		FOG0000201
OrthoInspector	1	1.000	-	-		mtm9740
orthoMCL	1	0.900	-	-		OOG6_100184
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.800