back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ry and Aox4

DIOPT Version :9

Sequence 1:	NP_524337.1	Gene:	ry / 41605	FlyBaseID:	FBgn0003308	Length:	1335	Species:	Drosophila melanogaster
Sequence 2:	NP_001008523.2	Gene:	Aox4 / 316424	RGDID:	1311975	Length:	1333	Species:	Rattus norvegicus

Alignment Length:	1355	Identity:	600/1355 - (44%)
Similarity:	838/1355 - (61%)	Gaps:	51/1355 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SNSVLVFFVNGKKVTEVSPDPECTLLTFLREKLRLCGTKLGCAEGGCGACTVMVSRLDRRANKIR 66
            |:..|:||||||||.|.:|.||..||.::|:.|.|.|||..|..|||||||||:||.:..:.||.
  Rat     4 SSDELIFFVNGKKVIEKNPVPEMNLLFYVRKVLHLTGTKYSCGGGGCGACTVMISRYNPESKKIY 68

  Fly    67 HLAVNACLTPVCSMHGCAVTTVEGIGSTKTRLHPVQERLAKAHGSQCGFCTPGIVMSMYALLRNA 131
            |....|||.||||:||.|||||||:||.|.|:|||||||||.||:|||||:||:|||:|.||||.
  Rat    69 HYPATACLVPVCSLHGAAVTTVEGVGSIKRRIHPVQERLAKCHGTQCGFCSPGMVMSIYTLLRNH 133

  Fly   132 EQPSMRDLEVAFQGNLCRCTGYRPILEGYKTFTKEFA-CGM--GEKCCKVSGKGC--GTDAETDD 191
            .:|:...:..|..||||||||||||:|..|||:.|.: |.|  ..|||....:||  .|......
  Rat   134 PEPTPDQITEALGGNLCRCTGYRPIVESGKTFSPESSVCQMKGSGKCCMDLDEGCSESTKERMCT 198

  Fly   192 KLFERSEFQPLDPSQEPIFPPEL-QLSDAFDSQSLIFSSDRVTWYRPTNLEELLQLKAKHPAAKL 255
            ||:...||||||||||||||||| ::::....:.|.|..:|..|..|..|.:||:|||.:|.|.|
  Rat   199 KLYNEDEFQPLDPSQEPIFPPELIRMAEDPHKRRLTFQGERTIWIMPVTLNDLLELKASYPEAPL 263

  Fly   256 VVGNTEVGVEVKFKHFLYPHLINPTQVKELLEIKENQDGIYFGAAVSLMEIDALLRQRIEQLPES 320
            |:|||.||..:||.:..:|..|:|..:.||..:.....|:..||..||.::..:|.....:.|:.
  Rat   264 VMGNTAVGPGMKFNNEFHPVFISPLGLPELNLVDTANSGVTIGARHSLAQMKDILHSLTLEQPKE 328

  Fly   321 ETRLFQCTVDMLHYFAGKQIRNVACLGGNIMTGSPISDMNPVLSAAGAQLEVASFVDGKLQKRSV 385
            :|:..|..:..|...||.||||:|.|||::::....||:||:|:|..|.:.|.|    |..:|.:
  Rat   329 KTKTHQALLKHLRTLAGPQIRNMATLGGHVVSRPDFSDLNPILAAGNATINVIS----KEGQRQI 389

  Fly   386 HMGTGFFTGYRRNVIEAHEVLLGIHFRKTTPDQYIVAFKQARRRDDDIAIVNAAINVRFEEKSNI 450
            .:...|........::..||.|.:....:...||:...:.|:|:::..|||||.::|.|||.:|.
  Rat   390 PLNGPFLERLPEASLKPEEVALSVFIPYSGQWQYVSGLRLAQRQENAFAIVNAGMSVEFEEGTNT 454

  Fly   451 VAEISMAFGGMAPTTVLAPRTSQLMVGQEWSHQLVERVAESLCTELPLAASAPGGMIAYRRALVV 515
            :.::.|.||.:|||.|.|.:|.:.::|::|..|::....:.:..|:.:...|.|||:.|||.|::
  Rat   455 IKDLQMLFGSVAPTVVSASQTCKQLIGRQWDDQMLSDACQLVLEEIRIPPDAEGGMVEYRRTLII 519

  Fly   516 SLFFKAYLAISLKLSKSG-----------ITSSDALPSEERSGAETFHTPVLKSAQLFERVCSDQ 569
            ||.||.||.:...||:..           :::.|.||.|         ||  :..|:|:.|..:|
  Rat   520 SLLFKFYLKVRRWLSEMDPQKFPDIPEKFVSALDDLPIE---------TP--QGIQMFQCVDPNQ 573

  Fly   570 PICDPIGRPKVHAAALKQATGEAIYTDDIPRMDGEVYLAFVLSTKPRAKITKLDASEALALDGVH 634
            |..||:|.|.:|.:.:|.|||||.:.||:||::.|:.|..|.||:..||||.:|.|||||..||.
  Rat   574 PEQDPVGHPIMHQSGIKHATGEAKFVDDMPRINQELCLTVVTSTRAHAKITSIDVSEALAYPGVV 638

  Fly   635 QFFCYKDLTEHENEVGPVFHDEHVFAAGEVHCYGQIVGAIAADNKALAQRAARLVKVEYEELSPV 699
            .....:|:....|..|.:|     :|..||.|.|||:..:|||....|:.||:.||:.|:::.|.
  Rat   639 DVITAEDVPGDNNHSGEIF-----YAQNEVICVGQIICTVAADTYIHAKEAAKRVKITYDDIEPA 698

  Fly   700 IVTIEQAIEHKSYFPDYPRFVTKGNVEEALAQADHTFEGTCRMGGQEHFYLETHAALAVPRDSD- 763
            |:|||||:||.|:.....: :.:|||:.|....||..||...:.||||||:||...||:|:..|
  Rat   699 IITIEQALEHNSFLSSEKK-IEQGNVDYAFKHVDHIIEGEIHVEGQEHFYMETQTILAIPQTEDK 762

  Fly   764 ELELFCSTQHPSEVQKLVAHVTALPAHRVVCRAKRLGGGFGGKESRGISVALPVALAAYRMGRPV 828
            |:.|...||.|:.||:.|:....:|.:|:.|:.||.||.||||.::...:....|:||::.|||:
  Rat   763 EMVLHVGTQFPTHVQEYVSAALKVPRNRIACQMKRTGGAFGGKVTKPALLGAVCAVAAHKTGRPI 827

  Fly   829 RCMLDRDEDMLITGTRHPFLFKYKVGFTKEGLITACDIECYNNAGWSMDLSFSVLERAMFHFENC 893
            |.:|||..|||||..|||.|.|||:||...|.|.|.|:|.|.|.|.:.|.|..|:|..:...||.
  Rat   828 RFILDRSNDMLITAGRHPLLGKYKIGFMNNGKIKAADVEYYTNGGCTPDESEMVIEFIVLKSENA 892

  Fly   894 YRIPNVRVGGWVCKTNLPSNTAFRGFGGPQGMYAGEHIIRDVARIVGRDVVDVMRLNFYKTGDYT 958
            |.|||.|..|..|||||||||||||||.||.....|..|..||........::..:|.||....|
  Rat   893 YHIPNFRCRGRACKTNLPSNTAFRGFGFPQATVVVEAYIAAVASKCNLLPEEIREINMYKQISKT 957

  Fly   959 HYHQQLEHFPIERCLEDCLKQSRYDEKRQEIARFNRENRWRKRGMAVVPTKYGIAFGVMHLNQAG 1023
            .|.|.....|:.||.::||::|.:..::|....||:.|.|:|:|:||||.|:.:|..:...|||.
  Rat   958 AYKQTFNPEPLRRCWKECLQKSSFFARKQAAEEFNKNNYWKKKGLAVVPMKFSVAVPMAFYNQAA 1022

  Fly  1024 SLINIYGDGSVLLSHGGVEIGQGLNTKMIQCAARALGIPSELIHISETATDKVPNTSPTAASVGS 1088
            :|::|:.||||||:|||.|:||||:|||||.|:|.|.||...:|:.||:|..|||...||.|:|:
  Rat  1023 ALVHIFLDGSVLLTHGGCELGQGLHTKMIQVASRELNIPKSYVHLVETSTVTVPNAVFTAGSMGA 1087

  Fly  1089 DLNGMAVLDACEKLNKRLAPIKEALPGGTWKEWINKAYFDRVSLSATGFYAMPGIGYHPETN--- 1150
            |:||.||.:||:.|..||.||.:..|.|.|:||:.||:.:.:||||||::.    ||  :||
  Rat  1088 DINGKAVQNACQTLLDRLQPIIKKNPKGKWEEWVKKAFEESISLSATGYFK----GY--QTNMDW 1146

  Fly  1151 --PNARTYSYYTNGVGVTVVEIDCLTGDHQVLSTDIVMDIGSSLNPAIDIGQIEGAFMQGYGLFT 1213
              .....|.||..|...:.||:|||||.|::|.|||.||...|:|||:||||:||||:||.|.:|
  Rat  1147 EKEEGDPYPYYVYGAACSEVEVDCLTGAHKLLRTDIFMDAAFSINPALDIGQVEGAFIQGMGFYT 1211

  Fly  1214 LEELMYSPQGMLYSRGPGMYKLPGFADIPGEFNVSLLTGAPNPRAVYSSKAVGEPPLFIGSSAFF 1278
            :|||.|||:|:||||||..||:|...:||.||.|:::. :.||.|:||||.:||..:|:|||..|
  Rat  1212 IEELKYSPKGVLYSRGPDDYKIPTVTEIPEEFYVTMVR-SRNPIAIYSSKGLGEAGMFLGSSVLF 1275

  Fly  1279 AIKEAIAAAREDQGLSGDFPLEAPSTSARIRIACQDKFTELLEIPEPGSFTPWNI 1333
            ||.:|:..||:::|||..|||.:|:|...||:||:|:||:::...:|.:||||:|
  Rat  1276 AIYDAVTTARKERGLSDIFPLNSPATPEVIRMACKDQFTDMIPRDDPSTFTPWSI 1330

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.