DRSC/TRiP Functional Genomics Resources

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Protein Alignment ry and AOX1

DIOPT Version :9

Sequence 1:NP_524337.1 Gene:ry / 41605 FlyBaseID:FBgn0003308 Length:1335 Species:Drosophila melanogaster
Sequence 2:XP_011509364.1 Gene:AOX1 / 316 HGNCID:553 Length:1350 Species:Homo sapiens


Alignment Length:1336 Identity:593/1336 - (44%)
Similarity:857/1336 - (64%) Gaps:38/1336 - (2%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 SVLVFFVNGKKVTEVSPDPECTLLTFLREKLRLCGTKLGCAEGGCGACTVMVSRLDRRANKIRHL 68
            |.|:|:|||:||.|.:.|||..||.:||:||||.|||.||..|||||||||:||.:....:|||.
Human     5 SELLFYVNGRKVIEKNVDPETMLLPYLRKKLRLTGTKYGCGGGGCGACTVMISRYNPITKRIRHH 69

  Fly    69 AVNACLTPVCSMHGCAVTTVEGIGSTKTRLHPVQERLAKAHGSQCGFCTPGIVMSMYALLRNAEQ 133
            ..||||.|:||::|.|||||||||||.||:||||||:||.||:||||||||:|||:|.||||..:
Human    70 PANACLIPICSLYGAAVTTVEGIGSTHTRIHPVQERIAKCHGTQCGFCTPGMVMSIYTLLRNHPE 134

  Fly   134 PSMRDLEVAFQGNLCRCTGYRPILEGYKTFTKEFACGMGEK---CCKVSG--------KGCGTDA 187
            |::..|..|..||||||||||||::..|||.|...|...::   ||...|        :|    :
Human   135 PTLDQLTDALGGNLCRCTGYRPIIDACKTFCKTSGCCQSKENGVCCLDQGINGLPEFEEG----S 195

  Fly   188 ETDDKLFERSEFQPLDPSQEPIFPPELQLSDAFDSQ-SLIFSSDRVTWYRPTNLEELLQLKAKHP 251
            :|..|||...||.||||:||.||||||.:.....|| :.:|.|:|:.|:.|..|:|||:.|.|:|
Human   196 KTSPKLFAEEEFLPLDPTQELIFPPELMIMAEKQSQRTRVFGSERMMWFSPVTLKELLEFKFKYP 260

  Fly   252 AAKLVVGNTEVGVEVKFKHFLYPHLINPTQVKELLEIKENQDGIYFGAAVSLMEIDALLRQRIEQ 316
            .|.:::|||.||.|||||...:|.:|:|.:::||..:....:|:..||.:||.::..:|...:::
Human   261 QAPVIMGNTSVGPEVKFKGVFHPVIISPDRIEELSVVNHAYNGLTLGAGLSLAQVKDILADVVQK 325

  Fly   317 LPESETRLFQCTVDMLHYFAGKQIRNVACLGGNIMTGSPISDMNPVLSAAGAQLEVASFVDGKLQ 381
            |||.:|:::...:..|...||.||||:|.|||:|::..|.||:||:|:.....|.:.|    |..
Human   326 LPEEKTQMYHALLKHLGTLAGSQIRNMASLGGHIISRHPDSDLNPILAVGNCTLNLLS----KEG 386

  Fly   382 KRSVHMGTGFFTGYRRNVIEAHEVLLGIHFRKTTPDQYIVAFKQARRRDDDIAIVNAAINVRFEE 446
            ||.:.:...|.:......::..|:|:.::...:...:::.||:||:|:::.:||||:.:.|.|.|
Human   387 KRQIPLNEQFLSKCPNADLKPQEILVSVNIPYSRKWEFVSAFRQAQRQENALAIVNSGMRVFFGE 451

  Fly   447 KSNIVAEISMAFGGMAPTTVLAPRTSQLMVGQEWSHQLVERVAESLCTELPLAASAPGGMIAYRR 511
            ...|:.|:.:::||:.|.|:.|..:.|.::|:.|:.|:::.....:..|:.|..|||||.:.::|
Human   452 GDGIIRELCISYGGVGPATICAKNSCQKLIGRHWNEQMLDIACRLILNEVSLLGSAPGGKVEFKR 516

  Fly   512 ALVVSLFFKAYLAISLKLSKSGITSSDALPSEERSGAETFHTPVLKSAQLFERVCSDQPICDPIG 576
            .|::|..||.||.:|..|.|.......:|..:..|..|..|:....|...::.:...|...||||
Human   517 TLIISFLFKFYLEVSQILKKMDPVHYPSLADKYESALEDLHSKHHCSTLKYQNIGPKQHPEDPIG 581

  Fly   577 RPKVHAAALKQATGEAIYTDDIPRMDGEVYLAFVLSTKPRAKITKLDASEALALDGVHQFFCYKD 641
            .|.:|.:.:|.|||||||.||:|.:|.|::|.||.|::..|||..:|.||||::.||....    
Human   582 HPIMHLSGVKHATGEAIYCDDMPLVDQELFLTFVTSSRAHAKIVSIDLSEALSMPGVVDIM---- 642

  Fly   642 LTEHENEVGP--VFHD-EHVFAAGEVHCYGQIVGAIAADNKALAQRAARLVKVEYEELSPVIVTI 703
            ..||.::|..  .|.: |...|..:|.|.||:|.|:.||::..|:|||:.||:.|::|.|:|:||
Human   643 TAEHLSDVNSFCFFTEAEKFLATDKVFCVGQLVCAVLADSEVQAKRAAKRVKIVYQDLEPLILTI 707

  Fly   704 EQAIEHKSYF-PDYPRFVTKGNVEEALAQADHTFEGTCRMGGQEHFYLETHAALAVPRDSD-ELE 766
            |::|:|.|.| |:  |.:..|||:||....|...||...||||||||:||.:.|.||:..| |::
Human   708 EESIQHNSSFKPE--RKLEYGNVDEAFKVVDQILEGEIHMGGQEHFYMETQSMLVVPKGEDQEMD 770

  Fly   767 LFCSTQHPSEVQKLVAHVTALPAHRVVCRAKRLGGGFGGKESRGISVALPVALAAYRMGRPVRCM 831
            ::.|||.|..:|.:||....|||::|:|..:|:||.||||..:...:|...|.||.:.||.|||:
Human   771 VYVSTQFPKYIQDIVASTLKLPANKVMCHVRRVGGAFGGKVLKTGIIAAVTAFAANKHGRAVRCV 835

  Fly   832 LDRDEDMLITGTRHPFLFKYKVGFTKEGLITACDIECYNNAGWSMDLSFSVLERAMFHFENCYRI 896
            |:|.|||||||.|||:|.|||.||..:|.|.|.|:|.|:|||.|:|.|..|:|..:...:|.|:.
Human   836 LERGEDMLITGGRHPYLGKYKAGFMNDGRILALDMEHYSNAGASLDESLFVIEMGLLKMDNAYKF 900

  Fly   897 PNVRVGGWVCKTNLPSNTAFRGFGGPQGMYAGEHIIRDVARIVGRDVVDVMRLNFYKTGDYTHYH 961
            ||:|..||.|:|||||||||||||.||.....|..|.:||...|.....|..:|.||..|.|.|.
Human   901 PNLRCRGWACRTNLPSNTAFRGFGFPQAALITESCITEVAAKCGLSPEKVRIINMYKEIDQTPYK 965

  Fly   962 QQLEHFPIERCLEDCLKQSRYDEKRQEIARFNRENRWRKRGMAVVPTKYGIAFGVMHLNQAGSLI 1026
            |::....:.:|..:|:..|.|..::..:.:||.||.|:|:|:|:||.|:.:..|.....||.:|:
Human   966 QEINAKNLIQCWRECMAMSSYSLRKVAVEKFNAENYWKKKGLAMVPLKFPVGLGSRAAGQAAALV 1030

  Fly  1027 NIYGDGSVLLSHGGVEIGQGLNTKMIQCAARALGIPSELIHISETATDKVPNTSPTAASVGSDLN 1091
            :||.|||||::|||:|:|||::|||||..:|.|.:|...:|:..|:|:.|||.:.:..||.:|||
Human  1031 HIYLDGSVLVTHGGIEMGQGVHTKMIQVVSRELRMPMSNVHLRGTSTETVPNANISGGSVVADLN 1095

  Fly  1092 GMAVLDACEKLNKRLAPIKEALPGGTWKEWINKAYFDRVSLSATGFYAMPGIGYHPETN---PNA 1153
            |:||.|||:.|.|||.||....|.||||:|...|:.:.::|||.|::.    ||..:.|   ...
Human  1096 GLAVKDACQTLLKRLEPIISKNPKGTWKDWAQTAFDESINLSAVGYFR----GYESDMNWEKGEG 1156

  Fly  1154 RTYSYYTNGVGVTVVEIDCLTGDHQVLSTDIVMDIGSSLNPAIDIGQIEGAFMQGYGLFTLEELM 1218
            :.:.|:..|...:.||||||||||:.:.||||||:|.|:|||||||||||||:||.||:|:|||.
Human  1157 QPFEYFVYGAACSEVEIDCLTGDHKNIRTDIVMDVGCSINPAIDIGQIEGAFIQGMGLYTIEELN 1221

  Fly  1219 YSPQGMLYSRGPGMYKLPGFADIPGEFNVSLLTGAPNPRAVYSSKAVGEPPLFIGSSAFFAIKEA 1283
            |||||:|::|||..||:|...|:|.|.:::||..:.|...:||||.:||..:|:|.|.||||.:|
Human  1222 YSPQGILHTRGPDQYKIPAICDMPTELHIALLPPSQNSNTLYSSKGLGESGVFLGCSVFFAIHDA 1286

  Fly  1284 IAAAREDQGLSGDFPLEAPSTSARIRIACQDKFTEL 1319
            ::|||:::||.|...|.:|.|..:||:||:||||::
Human  1287 VSAARQERGLHGPLTLNSPLTPEKIRMACEDKFTKM 1322

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ryNP_524337.1 Fer2 8..78 CDD:278537 42/69 (61%)
PLN02906 25..1317 CDD:215491 579/1311 (44%)
Fer2_2 87..158 CDD:280048 51/70 (73%)
FAD_binding_5 231..411 CDD:279309 62/179 (35%)
CO_deh_flav_C 422..525 CDD:281449 37/102 (36%)
Ald_Xan_dh_C 589..696 CDD:279635 46/109 (42%)
Ald_Xan_dh_C2 716..1242 CDD:280834 252/529 (48%)
AOX1XP_011509364.1 mam_aldehyde_ox 5..1328 CDD:132014 593/1336 (44%)
Fer2_2 88..161 CDD:280048 51/72 (71%)
FAD_binding_5 239..419 CDD:279309 62/183 (34%)
CO_deh_flav_C 426..530 CDD:281449 37/103 (36%)
Ald_Xan_dh_C 594..701 CDD:214971 46/110 (42%)
Ald_Xan_dh_C2 720..1245 CDD:280834 252/530 (48%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165147666
Domainoid 1 1.000 101 1.000 Domainoid score I6958
eggNOG 1 0.900 - - E1_COG4631
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG54386
OrthoDB 1 1.010 - - D48717at2759
OrthoFinder 1 1.000 - - FOG0000201
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100184
Panther 1 1.100 - - O PTHR11908
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X518
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1110.760

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