DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ry and gad-3

DIOPT Version :9

Sequence 1:	NP_524337.1	Gene:	ry / 41605	FlyBaseID:	FBgn0003308	Length:	1335	Species:	Drosophila melanogaster
Sequence 2:	NP_001294662.1	Gene:	gad-3 / 24104108	WormBaseID:	WBGene00015057	Length:	1257	Species:	Caenorhabditis elegans

Alignment Length:	1348	Identity:	477/1348 - (35%)
Similarity:	688/1348 - (51%)	Gaps:	135/1348 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VFF-VNGKKVTEVSPDPECTLLTFLREKLRLCGTKLGCAEGGCGACTVMVSRLDRRANKIRHLAV 70
            :|| ||||.|.|.:.|||.||..:||.||.|.||||||.||.||:|||::...|...||..:.||
Worm     6 IFFNVNGKDVNEENVDPELTLAYYLRNKLGLRGTKLGCEEGVCGSCTVVLGTWDDCQNKAVYRAV 70

  Fly    71 NACLTPVCSMHGCAVTTVEGIGSTKTRLHPVQERLAKAHGSQCGFCTPGIVMSMYALLRNAEQPS 135
            ||||.|:..:|...|.||||:|| :.::||:|:|:|:.|..|||||:||.|||.|||..|...|:
Worm    71 NACLVPLFHVHKTFVITVEGVGS-RDKIHPIQDRMARGHALQCGFCSPGFVMSAYALFSNQPNPT 134

  Fly   136 MRDLEVAFQGNLCRCTGYRPILEGYKTFTKEF--ACG---MGEKCCKVSGKGCGTDAETDDKLFE 195
            ::.:..|.:.|||||||||||||...:|:.|.  .||   .|..||| .......|...|:||..
Worm   135 IQQINAAIRANLCRCTGYRPILEALYSFSSESGGCCGGNKTGGGCCK-DKSSSDEDGGYDEKLLS 198

  Fly   196 RSEFQPLDPSQEPIFPPELQLSDAFDSQS-LIFSSDRVTWYRPTNLEELLQLKAKHPAAKLVVGN 259
            .::|...||:||.||||.|::..  ||:: :....||:....|.|:::..:.|..    :.|:.:
Worm   199 FNDFPKYDPTQEIIFPPSLRVFS--DSETPVTLKGDRIELLLPKNIDQFKKFKKD----RTVISS 257

  Fly   260 TEVGVEVKFKHFLYP-----HLINPTQVKELLEIKENQDGIYFGAAVSLMEIDALLRQRIEQLPE 319
               |:..:|.....|     ..|:...|||..||..|:|.:..|||:::.::...|...:.....
Worm   258 ---GLITRFVSTRNPKEFSQKWISTKYVKEFNEITVNKDSVVVGAALNIQKMADTLTSSLSINIG 319

  Fly   320 SETRLFQCTVDMLHYFAGKQIRNVACLGGNIMTGS----PISDMNPVLSAAGAQLEVASFVDGKL 380
            .|...|      :..|:..||.|.|...|.|::|:    .:||:..:.:...|:|.:.: ..|:|
Worm   320 KEIDSF------IQKFSSPQIANFATWTGAIISGAKSSLSVSDLLILFNVLDAKLTLLN-NSGEL 377

  Fly   381 QKRSVHMGTGFFTGYRRNVIEAHEVLLGIHFRKTTPDQYIVAFKQARRRDDDIAIVNAAINVRFE 445
            .:.::....      .:.:...|.::..|..|..|  .::...|.....:.|....|.|..|
Worm   378 TQVAIEEFA------EKKLFATHTIVNAIFSRSLT--GFLFCLKLGETSEQDSTNFNFAALV--- 431

  Fly   446 EKSNIVAEISMAFGGMAPTTVLAPRTSQLMVGQEWSHQLVERVAESLC--TELPLAASAPGGMIA 508
              .|.|:.|.:..||.      ..|.:.|.|..:   .|.......||  ||          |..
Worm   432 --GNQVSRIFVGLGGQ------PKRLTSLEVHID---ALKGLSVSDLCQTTE----------MSD 475

  Fly   509 YRRALVVSLFFKAYLAISLKLSKSGITSSDALPSEERSGAETFHTPVLKSAQLFERVCSDQPICD 573
            |:...:....|..::....|             :||..|        :...|.|:...::.
Worm   476 YKNVKIALTRFSDFMNHKEK-------------TEEIEG--------INYLQYFKPKTNES---- 515

  Fly   574 PIGRPKVHAAALKQATGEAIYTDDIPRMDGEVYLAFVLSTKPRAKITKLDASEALALDGVHQFFC 638
             .|||..:....:..||||.|.:||...:. |:|.|||||.|.|:|||:|.||||.|:||..:|.
Worm   516 -AGRPIANYFNERAITGEAFYVNDIQAYNA-VHLGFVLSTVPHAEITKIDVSEALQLEGVAGYFG 578

  Fly   639 YKDLTEHENEVG--------PVFHDEHVFAAGEVHCYGQIVGAIAADNKALAQRAARLVKVEYEE 695
            ..|:..: |..|        |  .|..:||..:|...||::|.|||::..||:|||:||||||:|
Worm   579 VSDVPGN-NTPGLQISNMNFP--DDTTIFADKKVESVGQVIGVIAANDVVLARRAAKLVKVEYKE 640

  Fly   696 LSPVIVTIEQAIEHKSYFPDYPRFVTKGN-VEEALAQADHTFEGTCRMGGQEHFYLETHAALAVP 759
            | |.:|..::|||.||...|...|....| |:|:|..:....||.|.:|||||:||||.::|.:|
Worm   641 L-PSLVNFKEAIEAKSLLGDVQHFGKDENLVKESLENSSKVLEGECDIGGQEHYYLETQSSLVIP 704

  Fly   760 RDSDELELFCSTQHPSEVQKLVAHVTALPAHRVVCRAKRLGGGFGGKESRGISVALPVALAAYRM 824
            .:.|||.:.||||..|..|.:||....:|||:::.:.||||||||||.:....:|...|:.|.::
Worm   705 GEGDELIVNCSTQGTSFTQLMVAETMKIPAHKIIVKTKRLGGGFGGKVNNASWIACMCAIVAKKL 769

  Fly   825 GRPVRCMLDRDEDMLITGTRHPFLFKYKVGFTKEGLITACDIECYNNAGWSMDLSFSVLERAMFH 889
            .||....|.|.:|:.|||.||....||:||...:|.|.....:.:.|.|||.|.|..|.......
Worm   770 NRPTYGFLSRADDLAITGKRHEVHAKYRVGINFDGKIEGIHYQAWLNGGWSKDHSEGVTMVMGLM 834

  Fly   890 FENCYRIPNVRVGGWVCKTNLPSNTAFRGFGGPQGMYAGEHIIRDVARIVGRDVVDVMRLNFYKT 954
            .::.|.:..:|..|:..|||..||||.||:|.||.....|.::|.:||.||:...::.|:||...
Worm   835 VDDVYNMGTIRFDGYPVKTNSNSNTALRGYGNPQSKLINEGVMRRIARDVGKSTEEIKRINFALE 899

  Fly   955 GDYTHYHQQLEHFPIERCLEDCLKQSRYDEKRQEIARFNRENRWRKRGMAVVPTKYGIAFGVMHL 1019
            |...:...::.:..:..|.|.|.|.|.::.::..|.:||:.:...|||:|:    ..:.||:.|.
Worm   900 GGRRYLGGKIHNDALVECWEYCKKWSEFENRQSGIKQFNKNSTAVKRGIAM----SSVRFGLPHP 960

  Fly  1020 NQAGS-----LINIYGDGSVLLSHGGVEIGQGLNTKMIQCAARALGIPSELIHISETATDKVPNT 1079
            ...|.     |||:  ||||.||.||.|:|||||.||:|..:.||..|.:.|.|.:.:||||.|.
Worm   961 GPTGHGIASLLINL--DGSVQLSIGGTEMGQGLNQKMLQVCSEALKRPIDTITIVDCSTDKVTNA 1023

  Fly  1080 SPTAASVGSDLNGMAVLDACEKLNKRLAPIKEALPGGTWKEWINKAYFDRVSLSATGF----YAM 1140
            ..|..|..:|.||:|||..|:|:..||.||.:. ..|.|::.|.:||...|.|..|.:    .|.
Worm  1024 PETGGSQNADTNGLAVLACCKKIMSRLQPIIDK-NDGEWEKSIREAYGAYVPLQCTEYGTVERAK 1087

  Fly  1141 PGIGYHPETNPNARTYSYYTNGVGVTVVEIDCLTGDHQVLSTDIVMDIGSSLNPAIDIGQIEGAF 1205
            .|:|  ...:|      |.|.|.....:|||.|||.::|:..|||||:|.|||||:|||||||||
Worm  1088 FGVG--EMESP------YNTTGACAVEMEIDTLTGYNRVIRVDIVMDVGESLNPALDIGQIEGAF 1144

  Fly  1206 MQGYGLFTLEELMYS-PQGMLYSRGPGMYKLPGFADIPGEFNVSLL-TGAPNPRAVYSSKAVGEP 1268
            :|||||.|.|::.:: ..|.|.....|.||:|..:|:|.:|.|.|| ....|...|||||.:|||
Worm  1145 IQGYGLVTCEKITFNKTTGQLDQNTAGKYKIPKASDVPKDFRVKLLGINNANGAQVYSSKGIGEP 1209

  Fly  1269 PLFIGSSAFF-AIKEAIAAAREDQGLSGDFPLEAPSTSARIRIACQDK 1315
            ||.:...|.. :|...|...|.:.|:.......:|.::.:|:..|..|
Worm  1210 PLMMSCGAVHSSIMNCIDNWRNENGIHEFVDTISPLSAEKIQELCSKK 1257

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ry	NP_524337.1	Fer2	8..78	CDD:278537	41/70 (59%)
		PLN02906	25..1317	CDD:215491	466/1329 (35%)
		Fer2_2	87..158	CDD:280048	39/70 (56%)
		FAD_binding_5	231..411	CDD:279309	38/188 (20%)
		CO_deh_flav_C	422..525	CDD:281449	21/104 (20%)
		Ald_Xan_dh_C	589..696	CDD:279635	53/114 (46%)
		Ald_Xan_dh_C2	716..1242	CDD:280834	210/536 (39%)
gad-3	NP_001294662.1	fer2	6..77	CDD:238126	40/70 (57%)
		PLN02906	23..1255	CDD:215491	465/1327 (35%)
		Fer2_2	87..158	CDD:280048	40/71 (56%)
		FAD_binding_4	<277..385	CDD:303082	28/114 (25%)
		Ald_Xan_dh_C	530..642	CDD:279635	55/116 (47%)
		Ald_Xan_dh_C2	661..1182	CDD:280834	210/535 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	88	1.000	Domainoid score	I5049
eggNOG	1	0.900	-	-		E1_COG4631
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D48717at2759
OrthoFinder	1	1.000	-	-		FOG0000201
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100184
Panther	1	1.100	-	-	O	PTHR11908
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.820