DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ry and Xdh

DIOPT Version :9

Sequence 1:	NP_524337.1	Gene:	ry / 41605	FlyBaseID:	FBgn0003308	Length:	1335	Species:	Drosophila melanogaster
Sequence 2:	NP_035853.2	Gene:	Xdh / 22436	MGIID:	98973	Length:	1335	Species:	Mus musculus

Alignment Length:	1349	Identity:	704/1349 - (52%)
Similarity:	932/1349 - (69%)	Gaps:	45/1349 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LVFFVNGKKVTEVSPDPECTLLTFLREKLRLCGTKLGCAEGGCGACTVMVSRLDRRANKIRHLAV 70
            ||||||||||.|.:.|||.|||.:||.||.||||||||.||||||||||:|:.||..|||.|.:|
Mouse     9 LVFFVNGKKVVEKNADPETTLLVYLRRKLGLCGTKLGCGEGGCGACTVMISKYDRLQNKIVHFSV 73

  Fly    71 NACLTPVCSMHGCAVTTVEGIGSTKTRLHPVQERLAKAHGSQCGFCTPGIVMSMYALLRNAEQPS 135
            ||||||:||:|..|||||||||:|| :|||||||:||:|||||||||||||||||.||||..:|:
Mouse    74 NACLTPICSLHHVAVTTVEGIGNTK-KLHPVQERIAKSHGSQCGFCTPGIVMSMYTLLRNKPEPT 137

  Fly   136 MRDLEVAFQGNLCRCTGYRPILEGYKTFTKEFAC----GMGEKCCKVSGKGCGTDAETDDK---- 192
            :.::|.||||||||||||||||:|::||.|:..|    |....||.         ::|.|:
Mouse   138 VEEIENAFQGNLCRCTGYRPILQGFRTFAKDGGCCGGSGNNPNCCM---------SQTKDQTIAP 193

  Fly   193 ---LFERSEFQPLDPSQEPIFPPE-LQLSDAFDSQSLIFSSDRVTWYRPTNLEELLQLKAKHPAA 253
               ||...:|:||||:|||||||| |:|.|. ..::|.|..:||||.:.:.:||||.|||:||.|
Mouse   194 SSSLFNPEDFKPLDPTQEPIFPPELLRLKDT-PRKTLRFEGERVTWIQVSTMEELLDLKAQHPDA 257

  Fly   254 KLVVGNTEVGVEVKFKHFLYPHLINPTQVKELLEIKENQDGIYFGAAVSLMEIDALLRQRIEQLP 318
            ||||||||:|:|:|||:.|:|.:|.|..:.||..:....:||.||||..|..::::|...|..||
Mouse   258 KLVVGNTEIGIEMKFKNMLFPLIICPAWILELTSVAHGPEGISFGAACPLSLVESVLADAIATLP 322

  Fly   319 ESETRLFQCTVDMLHYFAGKQIRNVACLGGNIMTGSPISDMNPVLSAAGAQLEVASFVDGKLQKR 383
            |..|.:|:..::.|.:|||||:::||.:||||:|.|||||:||||.|:.|:|.:||    :..||
Mouse   323 EQRTEVFRGVMEQLRWFAGKQVKSVASIGGNIITASPISDLNPVLMASRAKLTLAS----RGTKR 383

  Fly   384 SVHMGTGFFTGYRRNVIEAHEVLLGIHFRKTTPDQYIVAFKQARRRDDDIAIVNAAINVRFEEKS 448
            :|.|...||.||||.::...|:|:.|....:...::..|||||.||:||||.|.:.:.|.|:..:
Mouse   384 TVWMDHTFFPGYRRTLLSPEEILVSIVIPYSRKGEFFSAFKQASRREDDIAKVTSGMRVLFKPGT 448

  Fly   449 NIVAEISMAFGGMAPTTVLAPRTSQLMVGQEWSHQLVERVAESLCTELPLAASAPGGMIAYRRAL 513
            ..|.|:|:.|||||..||.|.:|:...:.:.|:.:|::.|...|..||.||..|||||:.:||.|
Mouse   449 TEVQELSLCFGGMADRTVSALKTTPKQLSKSWNEELLQDVCAGLAEELHLAPDAPGGMVEFRRTL 513

  Fly   514 VVSLFFKAYLAISLKLSKSGITS-SDALPSEERSGAETFHTPVLKSAQLFERVCSDQPICDPIGR 577
            .:|.|||.||.:..||.::.:.. ...|.....|....|......:.|||:.|...|...|.:||
Mouse   514 TLSFFFKFYLTVLQKLGRADLEGMCGKLDPTFASATLLFQKDPPANVQLFQEVPKGQSEEDMVGR 578

  Fly   578 PKVHAAALKQATGEAIYTDDIPRMDGEVYLAFVLSTKPRAKITKLDASEALALDGVHQFFCYKDL 642
            |..|.||..||:|||:|.|||||.:.|:.|..|.||:..|||..:|.|||..:.|   |.|:  |
Mouse   579 PMPHLAADMQASGEAVYCDDIPRYENELSLRLVTSTRAHAKIMSIDTSEAKKVPG---FVCF--L 638

  Fly   643 TEHE---NEVGPVFHDEHVFAAGEVHCYGQIVGAIAADNKALAQRAARLVKVEYEELSPVIVTIE 704
            |..:   :.:..:|:||.|||..||.|.|.|:||:.||....|.||||.||:.||:| |.|:||:
Mouse   639 TSEDVPGSNITGIFNDETVFAKDEVTCVGHIIGAVVADTPEHAHRAARGVKITYEDL-PAIITIQ 702

  Fly   705 QAIEHKSYF-PDYPRFVTKGNVEEALAQADHTFEGTCRMGGQEHFYLETHAALAVPR-DSDELEL 767
            .||::.|:: |:..  :.||::::..::||:...|...:|||||||||||..:|||: ::.|:||
Mouse   703 DAIKNNSFYGPEVK--IEKGDLKKGFSEADNVVSGELYIGGQEHFYLETHCTIAVPKGEAGEMEL 765

  Fly   768 FCSTQHPSEVQKLVAHVTALPAHRVVCRAKRLGGGFGGKESRGISVALPVALAAYRMGRPVRCML 832
            |.|||:..:.|..:|.:..:|.:|:|.|.||:||||||||:|...::..||||||:.||||||||
Mouse   766 FVSTQNTMKTQSFIAKMLGVPDNRIVVRVKRMGGGFGGKETRSTLISTAVALAAYKTGRPVRCML 830

  Fly   833 DRDEDMLITGTRHPFLFKYKVGFTKEGLITACDIECYNNAGWSMDLSFSVLERAMFHFENCYRIP 897
            ||||||||||.|||||.||||||.|.|.|.|.::..::|.|.|.|||.|::|||:||.:|.|:||
Mouse   831 DRDEDMLITGGRHPFLAKYKVGFMKTGTIVALEVAHFSNGGNSEDLSRSIMERAVFHMDNAYKIP 895

  Fly   898 NVRVGGWVCKTNLPSNTAFRGFGGPQGMYAGEHIIRDVARIVGRDVVDVMRLNFYKTGDYTHYHQ 962
            |:|..|.:||||||||||||||||||||...|:.:.:||...|....:|.|.|.||.||.||::|
Mouse   896 NIRGTGRICKTNLPSNTAFRGFGGPQGMLIAEYWMSEVAVTCGLPAEEVRRKNMYKEGDLTHFNQ 960

  Fly   963 QLEHFPIERCLEDCLKQSRYDEKRQEIARFNRENRWRKRGMAVVPTKYGIAFGVMHLNQAGSLIN 1027
            :||.|.:.||.::|:..|:|..::.|:.:|||||.|:|||:.::|||:||:|.:..|||.|:|::
Mouse   961 KLEGFTLPRCWDECIASSQYQARKMEVEKFNRENCWKKRGLCIIPTKFGISFTLSFLNQGGALVH 1025

  Fly  1028 IYGDGSVLLSHGGVEIGQGLNTKMIQCAARALGIPSELIHISETATDKVPNTSPTAASVGSDLNG 1092
            :|.||||||:|||.|:||||:|||:|.|:|||.||:..|||:||:|:.||||||||||..:||||
Mouse  1026 VYTDGSVLLTHGGTEMGQGLHTKMVQVASRALKIPTSKIHITETSTNTVPNTSPTAASASADLNG 1090

  Fly  1093 MAVLDACEKLNKRLAPIKEALPGGTWKEWINKAYFDRVSLSATGFYAMPGIGYHPETNPNARTYS 1157
            .|:.:||:.:.|||.|.|:..|.|:|:.|:..||...|||||||||..|.:||..||| :...:.
Mouse  1091 QAIYEACQTILKRLEPFKKKNPSGSWESWVMDAYTSAVSLSATGFYKTPNLGYSFETN-SGNPFH 1154

  Fly  1158 YYTNGVGVTVVEIDCLTGDHQVLSTDIVMDIGSSLNPAIDIGQIEGAFMQGYGLFTLEELMYSPQ 1222
            |::.||..:.||||||||||:.|.||||||:||||||||||||:||||:||.||||:|||.|||:
Mouse  1155 YFSYGVACSEVEIDCLTGDHKNLRTDIVMDVGSSLNPAIDIGQVEGAFVQGLGLFTMEELHYSPE 1219

  Fly  1223 GMLYSRGPGMYKLPGFADIPGEFNVSLLTGAPNPRAVYSSKAVGEPPLFIGSSAFFAIKEAIAAA 1287
            |.|::|||..||:|.|..||.||.||||...||.||:|:||||||||||:.||.|||||:||.||
Mouse  1220 GSLHTRGPSTYKIPAFGSIPIEFRVSLLRDCPNKRAIYASKAVGEPPLFLASSIFFAIKDAIRAA 1284

  Fly  1288 REDQGLSGD---FPLEAPSTSARIRIACQDKFTELLEIPEPGSFTPWNI 1333
            |...|.|..   |.|::|:|..:||.||.|:||.|.....|.:...|::
Mouse  1285 RAQHGDSNAKQLFQLDSPATPEKIRNACVDQFTTLCATGTPENCKSWSV 1333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ry	NP_524337.1	Fer2	8..78	CDD:278537	51/69 (74%)
		PLN02906	25..1317	CDD:215491	685/1312 (52%)
		Fer2_2	87..158	CDD:280048	55/70 (79%)
		FAD_binding_5	231..411	CDD:279309	87/179 (49%)
		CO_deh_flav_C	422..525	CDD:281449	48/102 (47%)
		Ald_Xan_dh_C	589..696	CDD:279635	50/109 (46%)
		Ald_Xan_dh_C2	716..1242	CDD:280834	295/526 (56%)
Xdh	NP_035853.2	PLN02906	26..1321	CDD:215491	689/1318 (52%)
		Fer2_2	90..160	CDD:280048	55/70 (79%)
		FAD_binding_5	234..414	CDD:279309	87/183 (48%)
		CO_deh_flav_C	421..525	CDD:281449	48/103 (47%)
		Ald_Xan_dh_C	590..696	CDD:279635	51/111 (46%)
		Ald_Xan_dh_C2	714..1239	CDD:280834	295/527 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837748
Domainoid	1	1.000	632	1.000	Domainoid score	I174
eggNOG	1	0.900	-	-		E1_COG4631
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H324
Inparanoid	1	1.050	1370	1.000	Inparanoid score	I128
Isobase	1	0.950	-	0	Normalized mean entropy	S3132
OMA	1	1.010	-	-		QHG54386
OrthoDB	1	1.010	-	-		D48717at2759
OrthoFinder	1	1.000	-	-		FOG0000201
OrthoInspector	1	1.000	-	-		oto91910
orthoMCL	1	0.900	-	-		OOG6_100184
Panther	1	1.100	-	-	LDO	PTHR11908
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3503
SonicParanoid	1	1.000	-	-		X518
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	16.790