DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ry and xdh-1

DIOPT Version :9

Sequence 1:	NP_524337.1	Gene:	ry / 41605	FlyBaseID:	FBgn0003308	Length:	1335	Species:	Drosophila melanogaster
Sequence 2:	NP_502747.1	Gene:	xdh-1 / 178381	WormBaseID:	WBGene00010083	Length:	1358	Species:	Caenorhabditis elegans

Alignment Length:	1365	Identity:	636/1365 - (46%)
Similarity:	874/1365 - (64%)	Gaps:	65/1365 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LVFFVNGKKVTEVSPDPECTLLTFLREKLRLCGTKLGCAEGGCGACTVMVSRLDRRANKIRHLAV 70
            |||:||||:|.|...||:.||.|:||:||:|.|||:||.||||||||:|:|.::.  .:|:|.:.
Worm    16 LVFYVNGKRVEEKDVDPKMTLATYLRDKLKLTGTKIGCNEGGCGACTIMISHIEN--GEIKHFSA 78

  Fly    71 NACLTPVCSMHGCAVTTVEGIGS-TKTRLHPVQERLAKAHGSQCGFCTPGIVMSMYALLRNAEQP 134
            |:||.|||.:.|.|||||||||| .|.|||||||||||||||||||||||.||:|||||||...|
Worm    79 NSCLMPVCGVFGKAVTTVEGIGSVAKNRLHPVQERLAKAHGSQCGFCTPGFVMAMYALLRNNPNP 143

  Fly   135 SMRDLEVAFQGNLCRCTGYRPILEGYKTF----------TKEFACGMGEKCCKVSGKGCGTDAET 189
            ::.|:.:..|||||||||||||||.:.:|          |:|..|||||.||||....||...||
Worm   144 TISDINLGLQGNLCRCTGYRPILEAFYSFAVDESGTLKVTEENGCGMGENCCKVKKTACGGSDET 208

  Fly   190 DD-----------KLFERSEFQPLDPSQEPIFPPELQLSDAFDSQSLIFSSDRVTWYRPTNLEEL 243
            ..           :|.:.|:.:|.||:||.||||||:| ..::|.|..:......||:|.:.::|
Worm   209 TPGYTGGERKRKIQLSDMSDCKPYDPTQELIFPPELKL-HGYESMSFAYDHHHTKWYQPVSYDDL 272

  Fly   244 LQLKAKHPAAKLVVGNTEVGVEVKFKHFLYPHLINPTQVKELLEIKENQDGIYFGAAVSLMEIDA 308
            |.||.:.|.|:|:.||:|:.:|:||:....|.:|||.|||.|.|.....||:|.|..:||.::|.
Worm   273 LSLKRELPHARLISGNSELAIELKFRFIDLPAVINPRQVKVLHEKHLENDGVYMGTGMSLTDMDN 337

  Fly   309 LLRQRIEQLPESETRLFQCTVDMLHYFAGKQIRNVACLGGNIMTGSPISDMNPVLSAAGAQLEVA 373
            ...|.::.||..:|.:.:...:|||:|||..:||||.:.|||.|.|||||:||:..|:.|.:.:.
Worm   338 YSVQLMKDLPREQTAVLKHVHEMLHWFAGIHVRNVASVAGNIATASPISDLNPIWMASNALVVLD 402

  Fly   374 SFVDGKLQKRSVHMGTGFFTGYRRNVIEAHEVLLGIHFRKTTPDQYIVAFKQARRRDDDIAIVNA 438
            |...|  :|| ||:...||.|||:.||:..|::..:.......:::..|:|||:||:||||||..
Worm   403 SEARG--EKR-VHIDEKFFLGYRKTVIQQDEIIKAVIVPLLEENEHFAAYKQAQRREDDIAIVTG 464

  Fly   439 AINVRFEEKSNIVAEISMAFGGMAPTTVLAPRTSQLMVGQEWSHQLVERVAESLCTELPLAASAP 503
            |..|:.:.|:.:|.:|.:::|||||||.||..|.:.::|::||...:::....|..||.|.|..|
Worm   465 AFLVKLDPKTLVVEKIRISYGGMAPTTKLALTTMEKLIGEKWSQTFLDKALGLLSDELKLPAGVP 529

  Fly   504 GGMIAYRRALVVSLFFKAYLAISLKLSKSGITSSDALPSEERSGAETFHTPVLKSAQLFERVCSD 568
            |||..||.:|.:|.|||.:|.:|.||..:.|...||.....::..||     |.:.||::.|.::
Worm   530 GGMSQYRLSLALSFFFKFFLGVSKKLELTEIKYVDADVKIGQNVPET-----LYATQLYQEVKAN 589

  Fly   569 QPICDPIGRPKVHAAALKQATGEAIYTDDIPRMDGEVYLAFVLSTKPRAKITKLDASEALALDGV 633
            ||..||:|||..|.:..|..||||:|.|||...|.. ::|||||......:..:|.:.||.:|||
Worm   590 QPAHDPLGRPIKHVSGDKHTTGEAVYCDDINVADCN-HIAFVLSPIAHGTLNSIDYTAALEIDGV 653

  Fly   634 HQFFCYKDLTE-----HENEVGPVFHDEHVFAAGEVHCYGQIVGAIAADNKALAQRAARLVKVEY 693
            .......|:|.     |.::. |||..|      .:..:||.:.||.|.:..:|::||.|||::|
Worm   654 VGTIDASDVTTGAQMGHHSDT-PVFVKE------TITFHGQPIAAIVATDHEIARKAASLVKLDY 711

  Fly   694 EELSPVIVTIEQAIEHKSYFPDYPRFVTKGNV---EEAL----AQADHTFEGTCRMGGQEHFYLE 751
            ....| ||||:||:|.:|:.  :..||...::   |:.:    ::.|...||:..||||||||||
Worm   712 SVEKP-IVTIKQALEAESFV--FKHFVIHSSLNDNEQVIKSDWSKYDRIVEGSIDMGGQEHFYLE 773

  Fly   752 THAALAVPRDSDELELFCSTQHPSEVQKLVAHVTALPAHRVVCRAKRLGGGFGGKESRGISVALP 816
            |...:.:|.:.||||:..|.|..::||..||....:..|::..:.||:|||||||||.|..:|:|
Worm   774 TQQCIVIPHEDDELEIIISNQCVNDVQIEVAKCLGMAQHKISTKVKRIGGGFGGKESTGAILAVP 838

  Fly   817 VALAAYRMGRPVRCMLDRDEDMLITGTRHPFLFKYKVGFTKEGLITACDIECYNNAGWSMDLSFS 881
            .:|||.:.|||::...:|.:||.||||||||..:||:...:.|.....|....:|:|.::|||..
Worm   839 ASLAAKKFGRPMKFKFERFDDMAITGTRHPFTLQYKLAVDENGKFLDLDYTALSNSGHTIDLSMG 903

  Fly   882 VLERAMFHFENCYRIPNVRVGGWVCKTNLPSNTAFRGFGGPQGMYAGEHIIRDVARIVGRDVVDV 946
            |::|||.|.:|.|:..|..:.|.:|||||.||||||||||||||:..|.:::.||...|.:..:|
Worm   904 VMQRAMVHADNVYKFENADITGKMCKTNLASNTAFRGFGGPQGMFGTEIMVKHVAEKFGFNHDEV 968

  Fly   947 MRLNFYKTGDYTHYHQQLEHFPIERCLEDCLKQSRYDEKRQEIARFNRENRWRKRGMAVVPTKYG 1011
            ...||||.||.|.:...|....:.|..::|.|.|.||.:.:|:.:||..|::||||:.:.||::|
Worm   969 RVKNFYKEGDCTPFGMHLNQCNVTRTWDECRKNSDYDNRLEEVKKFNDSNKFRKRGIYLTPTRFG 1033

  Fly  1012 IAFGVMHLNQAGSLINIYGDGSVLLSHGGVEIGQGLNTKMIQCAARALGIPSELIHISETATDKV 1076
            |.||:..|||||:|:.:|.|||||:||||:|:||||:||::|.|||.|.||.|.|||.:|:||||
Worm  1034 IGFGLKQLNQAGALVLVYTDGSVLVSHGGMEMGQGLHTKILQIAARCLEIPIERIHIHDTSTDKV 1098

  Fly  1077 PNTSPTAASVGSDLNGMAVLDACEKLNKRLAPIKEALPGGTWKEWINKAYFDRVSLSATGFYAMP 1141
            ||.|.||||||||:||:||.|||.::|:||...|:..|.|||.:|:..||.|||||||:||
Worm  1099 PNASATAASVGSDMNGLAVQDACRQINERLERFKKLDPNGTWDDWVKAAYVDRVSLSASGF---- 1159

  Fly  1142 GIGYHPETN----PNARTYSYYTNGVGVTVVEIDCLTGDHQVLSTDIVMDIGSSLNPAIDIGQIE 1202
            ||.:|...:    ..|..:.|...|.....||||||||||.:|.||||||:|.||||||||||||
Worm  1160 GIIHHEPVDFFNGKGAELFGYSVYGTACCEVEIDCLTGDHHLLRTDIVMDVGESLNPAIDIGQIE 1224

  Fly  1203 GAFMQGYGLFTLEELMYSPQGMLYSRGPGMYKLPGFADIPGEFNVSLLTGAPNPRAVYSSKAVGE 1267
            |||:|||||||:||:...|.|:..:||||.||:|...|.|..||||||..:.|...::||||:||
Worm  1225 GAFIQGYGLFTMEEIKIRPDGIRLTRGPGNYKIPSADDAPRHFNVSLLGNSSNKMGIFSSKAIGE 1289

  Fly  1268 PPLFIGSSAFFAIKEAIAAAREDQGLSGDFPLEAPSTSARIRIACQDKFT-ELLEIPEPGSFTPW 1331
            ||||:||.|||||:||:.|.|...|.:..|...:|:|..|||:||:|..| .:.|:||.|::|||
Worm  1290 PPLFLGSCAFFAIREAVRAYRIQNGNADYFVFHSPATPERIRMACEDFVTSHVPELPEEGTYTPW 1354

Fly 1332 1331
Worm 1355 1354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ry	NP_524337.1	Fer2	8..78	CDD:278537	38/69 (55%)
		PLN02906	25..1317	CDD:215491	617/1329 (46%)
		Fer2_2	87..158	CDD:280048	55/71 (77%)
		FAD_binding_5	231..411	CDD:279309	73/179 (41%)
		CO_deh_flav_C	422..525	CDD:281449	47/102 (46%)
		Ald_Xan_dh_C	589..696	CDD:279635	39/111 (35%)
		Ald_Xan_dh_C2	716..1242	CDD:280834	265/536 (49%)
xdh-1	NP_502747.1	Fer2	18..86	CDD:278537	38/69 (55%)
		PLN02906	34..1340	CDD:215491	617/1331 (46%)
		Fer2_2	95..168	CDD:280048	56/72 (78%)
		FAD_binding_5	260..440	CDD:279309	73/182 (40%)
		CO_deh_flav_C	447..549	CDD:281449	46/101 (46%)
		Ald_Xan_dh_C	610..715	CDD:279635	39/112 (35%)
		Ald_Xan_dh_C2	755..1264	CDD:280834	262/512 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159659
Domainoid	1	1.000	532	1.000	Domainoid score	I137
eggNOG	1	0.900	-	-		E1_COG4631
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H324
Inparanoid	1	1.050	1181	1.000	Inparanoid score	I101
Isobase	1	0.950	-	0	Normalized mean entropy	S3132
OMA	1	1.010	-	-		QHG54386
OrthoDB	1	1.010	-	-		D48717at2759
OrthoFinder	1	1.000	-	-		FOG0000201
OrthoInspector	1	1.000	-	-		oto17310
orthoMCL	1	0.900	-	-		OOG6_100184
Panther	1	1.100	-	-	LDO	PTHR11908
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3503
SonicParanoid	1	1.000	-	-		X518
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750