DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ry and aox1

DIOPT Version :9

Sequence 1:	NP_524337.1	Gene:	ry / 41605	FlyBaseID:	FBgn0003308	Length:	1335	Species:	Drosophila melanogaster
Sequence 2:	XP_012825683.2	Gene:	aox1 / 100495429	-ID:	-	Length:	1323	Species:	Xenopus tropicalis

Alignment Length:	1348	Identity:	642/1348 - (47%)
Similarity:	879/1348 - (65%)	Gaps:	46/1348 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSNSVLVFFVNGKKVTEVSPDPECTLLTFLREKLRLCGTKLGCAEGGCGACTVMVSRLDRRANKI 65
            :.:..|:|||||:|:.|.:.|||..||.:||:||.|.|||.||..|||||||||||.:...:.||
Frog     5 VDSHTLIFFVNGRKIVEENADPEELLLPYLRKKLLLTGTKYGCGGGGCGACTVMVSTIHPVSKKI 69

  Fly    66 RHLAVNACLTPVCSMHGCAVTTVEGIGSTKTRLHPVQERLAKAHGSQCGFCTPGIVMSMYALLRN 130
            .|.:.||||.|:|||||.||||:||||||.|:|||||||:||||||||||||||:|||:|:||||
Frog    70 LHFSANACLLPICSMHGAAVTTIEGIGSTTTKLHPVQERIAKAHGSQCGFCTPGMVMSVYSLLRN 134

  Fly   131 AEQPSMRDLEVAFQGNLCRCTGYRPILEGYKTFTKEFACGMGEKCCKVSGKGCG--TDAETDDK- 192
            ..:|:|..:..:..||||||||||||::|.:||     |...: ||:|...|..  :..:|.|.
Frog   135 HPEPTMEQIYESLGGNLCRCTGYRPIVDGCRTF-----CNKTD-CCQVKENGMEKISTPDTVDNI 193

  Fly   193 ---LFERSEFQPLDPSQEPIFPPELQLSDAFDSQSLIFSSDRVTWYRPTNLEELLQLKAKHPAAK 254
               ||:..:|.||||:||.||||||.|.|....:.|||...|:||..|::|:|||||||.:|.|.
Frog   194 LTGLFKEEQFLPLDPTQELIFPPELLLMDKEKKEKLIFQGGRMTWISPSSLQELLQLKATYPKAP 258

  Fly   255 LVVGNTEVGVEVKFKHFLYPHLINPTQVKELLEIKENQDGIYFGAAVSLMEIDALLRQRIEQLPE 319
            ||||||.||.|:||:...:|.:|:|:::.||..:....|||..|||.||..:...|::.:.|.||
Frog   259 LVVGNTIVGPEMKFRGIFHPVIISPSRIPELNFVIHKDDGITVGAACSLTVLKEALKEVVTQQPE 323

  Fly   320 SETRLFQCTVDMLHYFAGKQIRNVACLGGNIMTGSPISDMNPVLSAAGAQLEVASFVDGKLQKRS 384
            .:|:||...:..|....|.||||.|.|||||::.||.||:||||:|....|.||: :||   .|.
Frog   324 EKTKLFHALLQQLETLGGPQIRNTASLGGNIISRSPTSDLNPVLAAGNCILTVAA-IDG---TRQ 384

  Fly   385 VHMGTGFFTGYRRNVIEAHEVLLGIHFRKTTPDQYIVAFKQARRRDDDIAIVNAAINVRFEEKSN 449
            :.:...||.    :.::|.|||:.:|...:....:...|:||:||::.:.||.|.:.|:|||.::
Frog   385 MPLDEAFFA----HSLKAEEVLVSVHLPYSKKGDHYSVFRQAQRRENALPIVTAGMKVQFEENTD 445

  Fly   450 IVAEISMAFGGMAPTTVLAPRTSQLMVGQEWSHQLVERVAESLCTELPLAASAPGGMIAYRRALV 514
            |:..|.:.:||:.||||.|..|.|.::|:.|...::......:..|:.|:.||||||:.||..|.
Frog   446 IIKVIRIFYGGVGPTTVFAKTTCQDLIGKHWDDHMLSEACRLMVHEITLSPSAPGGMVEYRSTLT 510

  Fly   515 VSLFFKAYLAISLKLSKSGITSSDALPSEERSGAETFHTPVLKSAQLFERVCSDQPICDPIGRPK 579
            :|.|||.||.:..:|:..|...||.      |...:|.|...::.||::.|.|.|.:.||||||.
Frog   511 ISFFFKFYLEVLQRLNHMGTHYSDV------SALNSFETLCNENVQLYQDVSSRQSVQDPIGRPI 569

  Fly   580 VHAAALKQATGEAIYTDDIPRMDGEVYLAFVLSTKPRAKITKLDASEALALDGVHQFFCYKDLTE 644
            :|.:.:|.|||||:|.||:|.:|||::|.||.|||..|||..||.|||||..||      .|:..
Frog   570 MHYSGIKHATGEAVYCDDMPCVDGELFLYFVTSTKAHAKIVSLDFSEALAQPGV------VDVVT 628

  Fly   645 HENEVG---PVFHDEHV--FAAGEVHCYGQIVGAIAADNKALAQRAARLVKVEYEELSPVIVTIE 704
            .|:..|   .:|.:..|  .|..:|.|.|||:.|:.||..|.|::||..|||.||.|.|||:||:
Frog   629 TEDCPGTCKSMFEEGEVPLLAKDKVLCVGQIICAVLADTPARAKKAAAAVKVVYENLEPVILTIQ 693

  Fly   705 QAIEHKSYFPDYPRFVTKGNVEEALAQADHTFEGTCRMGGQEHFYLETHAALAVPRDSD-ELELF 768
            :||||.|:|.. .|.:..||||||...||...||...:|||||||:||.:...:|:..| |::::
Frog   694 EAIEHNSFFKP-QRKLENGNVEEAFKSADQIQEGEIYIGGQEHFYMETQSIRVLPKGEDKEMDVY 757

  Fly   769 CSTQHPSEVQKLVAHVTALPAHRVVCRAKRLGGGFGGKESRGISVALPVALAAYRMGRPVRCMLD 833
            .|||.|:.:|.|:|.:..:|::|:.|..||:||.||||.::..::|...|:||.:..|.|||:.:
Frog   758 VSTQDPTYIQNLIATILNVPSNRITCHVKRVGGAFGGKTTKTGNIAAITAVAANKTRRAVRCVFE 822

  Fly   834 RDEDMLITGTRHPFLFKYKVGFTKEGLITACDIECYNNAGWSMDLSFSVLERAMFHFENCYRIPN 898
            |.:||||||.|||||.||||||..:|.|||.|:..::|||.:.|.|..|:|.|:.:.::.||:||
Frog   823 RGDDMLITGGRHPFLGKYKVGFMNDGHITAVDVAYFSNAGCTPDDSVLVVEIALMNMDSAYRLPN 887

  Fly   899 VRVGGWVCKTNLPSNTAFRGFGGPQGMYAGEHIIRDVARIVGRDVVDVMRLNFYKTGDYTHYHQQ 963
            ||..|..|||||||||||||||.||..:..|..|.:||.........|..:|.||....||:.|:
Frog   888 VRCTGTACKTNLPSNTAFRGFGYPQAAFVTETWISEVAIKCRIPPEKVREMNLYKDISQTHFRQE 952

  Fly   964 LEHFPIERCLEDCLKQSRYDEKRQEIARFNRENRWRKRGMAVVPTKYGIAFGVMHLNQAGSLINI 1028
            :....:..|..:|:::|.|:.:|..|..||::|.|:|:|:|::|.|:.|........||.:|::|
Frog   953 ILARTLGMCWNECMEKSSYNSRRLAIENFNKDNYWKKKGLAIIPMKFPIGSLAKFFGQAAALVHI 1017

  Fly  1029 YGDGSVLLSHGGVEIGQGLNTKMIQCAARALGIPSELIHISETATDKVPNTSPTAASVGSDLNGM 1093
            |.|||||::|||:|:|||::||::|.|:|.||||...|||.||.|..||||..:..|:|:|:|||
Frog  1018 YLDGSVLVTHGGIEMGQGVHTKIMQIASRELGIPLSYIHICETNTSSVPNTQVSGGSLGTDVNGM 1082

  Fly  1094 AVLDACEKLNKRLAPIKEALPGGTWKEWINKAYFDRVSLSATGFYAMPGIGYHPET---NPNART 1155
            ||.:|||.|.:||.||:...|..:||||:.:||...||||||||........:.||   ||
Frog  1083 AVKNACEILMQRLLPIRSKNPKSSWKEWVTEAYMQSVSLSATGFCRSFDRELNWETGEGNP---- 1143

  Fly  1156 YSYYTNGVGVTVVEIDCLTGDHQVLSTDIVMDIGSSLNPAIDIGQIEGAFMQGYGLFTLEELMYS 1220
            ..|...||..:.||||||||||:.|.||||:|.|.|:|||:|||||||||:||.||||:|||.:|
Frog  1144 VHYCVYGVACSEVEIDCLTGDHKNLRTDIVIDFGCSINPAVDIGQIEGAFVQGLGLFTIEELKFS 1208

  Fly  1221 PQGMLYSRGPGMYKLPGFADIPGEFNVSLLTGAPNPRAVYSSKAVGEPPLFIGSSAFFAIKEAIA 1285
            |.|:||:|||..||:|...|||.:||||||:..||..|:||||.||||.||:|||.:||||:|:.
Frog  1209 PNGVLYTRGPAQYKIPSVRDIPEQFNVSLLSNVPNSCAIYSSKGVGEPALFLGSSIYFAIKDAVL 1273

  Fly  1286 AAREDQGLSGDFPLEAPSTSARIRIACQDKFTELLEIPEPGSFTPWNI 1333
            :||.::|:|..|.|.:|:|..:||:||.|:||:::....|||:.||.:
Frog  1274 SARRERGMSELFTLNSPATPEKIRMACGDQFTDMIPQNVPGSYVPWAV 1321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ry	NP_524337.1	Fer2	8..78	CDD:278537	41/69 (59%)
		PLN02906	25..1317	CDD:215491	624/1306 (48%)
		Fer2_2	87..158	CDD:280048	51/70 (73%)
		FAD_binding_5	231..411	CDD:279309	78/179 (44%)
		CO_deh_flav_C	422..525	CDD:281449	42/102 (41%)
		Ald_Xan_dh_C	589..696	CDD:279635	52/111 (47%)
		Ald_Xan_dh_C2	716..1242	CDD:280834	256/529 (48%)
aox1	XP_012825683.2	mam_aldehyde_ox	10..1323	CDD:132014	642/1343 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	99	1.000	Domainoid score	I6963
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54386
OrthoDB	1	1.010	-	-		D48717at2759
OrthoFinder	1	1.000	-	-		FOG0000201
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X518
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.930