DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CtBP and zgc:136929

DIOPT Version :9

Sequence 1:	NP_001262522.1	Gene:	CtBP / 41602	FlyBaseID:	FBgn0020496	Length:	481	Species:	Drosophila melanogaster
Sequence 2:	NP_001035480.1	Gene:	zgc:136929 / 678649	ZFINID:	ZDB-GENE-060421-4235	Length:	440	Species:	Danio rerio

Alignment Length:	470	Identity:	284/470 - (60%)
Similarity:	336/470 - (71%)	Gaps:	41/470 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDKNLMMPKRSRIDVKGNFANGPLQARPLVALLDGRDCSIEMPILKDVATVAFCDAQSTSEIHEK 65
            |..:.::.|...:.::....|||:..||||||||||||::|||||||||||||||||||.|||||
Zfish     1 MGSSHLLNKGLPLGIRPPIMNGPMHPRPLVALLDGRDCTVEMPILKDVATVAFCDAQSTQEIHEK 65

  Fly    66 VLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGTDNIDVKAAGELGIAVCNVPGYGVEEVAD 130
            ||||||||||:|||.|.:||||||||||||||||||.||||:|:||:|||||||:|...|||.||
Zfish    66 VLNEAVGALMYHTITLMREDLEKFKALRIIVRIGSGFDNIDIKSAGDLGIAVCNMPAASVEETAD 130

  Fly   131 TTMCLILNLYRRTYWLANMVREGKKFTGPEQVREAAHGCARIRGDTLGLVGLGRIGSAVALRAKA 195
            :|||.||||||||.||...:|||.:....||:||.|.|.|||||:|||::||||:|.||||||||
Zfish   131 STMCHILNLYRRTTWLHQALREGTRVQSVEQIREVASGAARIRGETLGIIGLGRVGQAVALRAKA 195

  Fly   196 FGFNVIFYDPYLPDGIDKSLGLTRVYTLQDLLFQSDCVSLHCTLNEHNHHLINEFTIKQMRPGAF 260
            |||:||||||||.||::::|||.||.|||||||.||||:|||:||||||||||:|||||||.|||
Zfish   196 FGFSVIFYDPYLSDGMERALGLQRVNTLQDLLFHSDCVTLHCSLNEHNHHLINDFTIKQMRQGAF 260

  Fly   261 LVNTARGGLVDDETLALALKQGRIRAAALDVHENEPYN---GALKDAPNLICTPHAAFFSDASAT 322
            |||||||||||::.||.|||:||||.|||||||.||::   |.||||||||||||||::|:.::.
Zfish   261 LVNTARGGLVDEKALAQALKEGRIRGAALDVHETEPFSFSQGPLKDAPNLICTPHAAWYSEQASI 325

  Fly   323 ELREMAATEIRRAIVGNIPDVLRNCVNKEYFMRTPPAAAAGGVAAAVYPEGLNGGYY--TGALHH 385
            |:||.||.||||||.|.|||.|:||||||:..:|  ...||...|.|:|| |||.|.  .|.:.|
Zfish   326 EMREEAAREIRRAITGRIPDSLKNCVNKEFLTQT--THWAGMDPAVVHPE-LNGAYRYPPGVVSH 387

  Fly   386 RAHSTTPHDGPHSTTNLGSTVGGGPTTVAQAAAAAVAAAAAAALLPSPVP-SHLSPQVGGLPLGI 449
            .:                   ||.|..|             ..::||.|| :|..|.|...|...
Zfish   388 AS-------------------GGLPPPV-------------EGIMPSAVPITHSLPTVAHPPHAP 420

  Fly   450 VSSQSPLSAPDPNNH 464
            ...|:....||...|
Zfish   421 SPGQTGKPEPDREQH 435

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CtBP	NP_001262522.1	CtBP_dh	28..342	CDD:240624	240/316 (76%)
CtBP	NP_001262522.1	LdhA	45..351	CDD:223980	232/308 (75%)
zgc:136929	NP_001035480.1	CtBP_dh	28..346	CDD:240624	241/317 (76%)
zgc:136929	NP_001035480.1	SerA	55..354	CDD:223189	222/298 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	492	1.000	Domainoid score	I357
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	531	1.000	Inparanoid score	I1178
OMA	1	1.010	-	-		QHG60148
OrthoDB	1	1.010	-	-		D305212at33208
OrthoFinder	1	1.000	-	-		FOG0001579
OrthoInspector	1	1.000	-	-		otm24526
orthoMCL	1	0.900	-	-		OOG6_102736
Panther	1	1.100	-	-	O	PTHR46029
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3406
SonicParanoid	1	1.000	-	-		X1820
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	12.010