DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CtBP and ctbp2l

DIOPT Version :9

Sequence 1:	NP_001262522.1	Gene:	CtBP / 41602	FlyBaseID:	FBgn0020496	Length:	481	Species:	Drosophila melanogaster
Sequence 2:	NP_001016866.1	Gene:	ctbp2l / 549620	XenbaseID:	XB-GENE-22063047	Length:	437	Species:	Xenopus tropicalis

Alignment Length:	480	Identity:	283/480 - (58%)
Similarity:	335/480 - (69%)	Gaps:	62/480 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDKNLMMPKRSRID-----VKGNFANGPLQARPLVALLDGRDCSIEMPILKDVATVAFCDAQSTS 60
            |||:.:  ||.|:|     ::....|||:..||||||||||||::|||||||||||||||||||.
Frog     1 MDKHKV--KRQRLDRICEGIRPPILNGPMPVRPLVALLDGRDCTVEMPILKDVATVAFCDAQSTQ 63

  Fly    61 EIHEKVLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGTDNIDVKAAGELGIAVCNVPGYGV 125
            |||||||:|||||||:|||.|::||||||||||||:|||||.||||:|:|.||||||||:|...|
Frog    64 EIHEKVLSEAVGALMYHTISLSREDLEKFKALRIIIRIGSGYDNIDIKSAAELGIAVCNIPSSSV 128

  Fly   126 EEVADTTMCLILNLYRRTYWLANMVREGKKFTGPEQVREAAHGCARIRGDTLGLVGLGRIGSAVA 190
            ||.||:|:|.|||||||..||...:|||.:....||:||.|.|.|||||:|||::||||||.|||
Frog   129 EETADSTLCHILNLYRRVTWLHQAMREGNRPASVEQIREVAGGAARIRGETLGIIGLGRIGQAVA 193

  Fly   191 LRAKAFGFNVIFYDPYLPDGIDKSLGLTRVYTLQDLLFQSDCVSLHCTLNEHNHHLINEFTIKQM 255
            ||||||.|.|||||||||||:::||||.|:.|||:||..|||::|||:||||||||||:||||||
Frog   194 LRAKAFNFTVIFYDPYLPDGVERSLGLQRMATLQELLMHSDCITLHCSLNEHNHHLINDFTIKQM 258

  Fly   256 RPGAFLVNTARGGLVDDETLALALKQGRIRAAALDVHENEPYN---GALKDAPNLICTPHAAFFS 317
            |.|.||||||||||||::.||.|||.||||.|||||||:||::   |.||||||||||||.|::|
Frog   259 RQGCFLVNTARGGLVDEKALAQALKDGRIRGAALDVHESEPFSFSQGPLKDAPNLICTPHTAWYS 323

  Fly   318 DASATELREMAATEIRRAIVGNIPDVLRNCVNKEYFMRTPPAAA--AGGVAAAVYPEGLNG-GYY 379
            :.::.|.||.||.||||||.|.|||.|||||||||.:    ||.  :|...|.|:|| ||| |.|
Frog   324 EHASIEAREEAAKEIRRAIAGPIPDALRNCVNKEYLL----AAVQWSGMEQATVHPE-LNGAGSY 383

  Fly   380 ---TGALHHRAHSTTPHDGPHSTTNLGSTVGGGPTTVAQAAAAAVAAAAAAALLPSPVPSH-LSP 440
               .|.                   :|.|..|.|:.:....|:                || |.|
Frog   384 RFPPGV-------------------VGVTTTGHPSAIEGLVAS----------------SHPLIP 413

  Fly   441 QVGGLPLGIVSSQSPLSAPDPNNHL 465
            .|...|     |....|.|||:..:
Frog   414 SVSHTP-----SPGQTSKPDPDREI 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CtBP	NP_001262522.1	CtBP_dh	28..342	CDD:240624	232/316 (73%)
CtBP	NP_001262522.1	LdhA	45..351	CDD:223980	225/308 (73%)
ctbp2l	NP_001016866.1	CtBP_dh	31..348	CDD:240624	232/316 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	492	1.000	Domainoid score	I373
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	527	1.000	Inparanoid score	I1206
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D305212at33208
OrthoFinder	1	1.000	-	-		FOG0001579
OrthoInspector	1	1.000	-	-		otm48011
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1820
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.060