DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CtBP and ctbp-1

DIOPT Version :9

Sequence 1:	NP_001262522.1	Gene:	CtBP / 41602	FlyBaseID:	FBgn0020496	Length:	481	Species:	Drosophila melanogaster
Sequence 2:	NP_001257030.1	Gene:	ctbp-1 / 180853	WormBaseID:	WBGene00006424	Length:	727	Species:	Caenorhabditis elegans

Alignment Length:	469	Identity:	223/469 - (47%)
Similarity:	305/469 - (65%)	Gaps:	34/469 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 NGPLQARPLVALLDGRDCSIEMPILKDVATVAFCDAQSTSEIHEKVLNEAVGALMWHTIILTKED 85
            |||..:|||||||||||||:|||||||||||||||||||.|||||||||||.|||:|:|.|.|||
Worm   172 NGPSSSRPLVALLDGRDCSVEMPILKDVATVAFCDAQSTQEIHEKVLNEAVAALMYHSIKLEKED 236

  Fly    86 LEKFKALRIIVRIGSGTDNIDVKAAGELGIAVCNVPGYGVEEVADTTMCLILNLYRRTYWLANMV 150
            |||||.|:::.|||.|.||||||||.|||||||:.||..||:|||:|:.|||:|:|||||.|...
Worm   237 LEKFKVLKVVFRIGYGIDNIDVKAATELGIAVCHAPGDYVEDVADSTLSLILDLFRRTYWHAKSY 301

  Fly   151 REGKKFTGPEQVREAAHGCARIRGDTLGLVGLGRIGSAVALRAKAFGFNVIFYDPYLPDGIDKSL 215
            .|.:|..|.:||||.|.|..::||..||::|.||:|:||.|||:|||.::|||||::.:|.||:|
Worm   302 SETRKTIGADQVRENAVGSKKVRGSVLGILGCGRVGTAVGLRARAFGLHIIFYDPFVREGHDKAL 366

  Fly   216 GLTRVYTLQDLLFQSDCVSLHCTLNEHNHHLINEFTIKQMRPGAFLVNTARGGLVDDETLALALK 280
            |..||||:.:.:.:|||:||||.|.:....:||..:::|.:.|.::|||:..||:::..||.|||
Worm   367 GFERVYTMDEFMSRSDCISLHCNLGDETRGIINADSLRQCKSGVYIVNTSHAGLINENDLAAALK 431

  Fly   281 QGRIRAAALDVHENEPYN----GALKDAPNLICTPHAAFFSDASATELREMAATEIRRAIVGNIP 341
            .|.::.||||||::..::    ..|...||:|.|||:|:.::||..:||..||.|||:||.|..|
Worm   432 NGHVKGAALDVHDSVRFDPNCLNPLVGCPNIINTPHSAWMTEASCKDLRINAAKEIRKAINGRCP 496

  Fly   342 DVLRNCVNKEYFMRTPPAAAAGGVAAAVYPEGLNGGYYTGALHHRAHSTTPH-DGPHSTTNLGST 405
            ..|.:|:|||..||.  :.......::.:|. ||.|:.| ..:....|.:|| ..|:....:|:.
Worm   497 QDLTHCINKEAVMRN--SNPINRRTSSAHPL-LNMGFPT-LPNFPPMSMSPHFPYPNPLLAMGAQ 557

  Fly   406 VGG-----GPTTVAQAAAAAVAAAAAAALLPSPVPSHLSPQVGGLPLGIVSSQSPLSAPDPNNHL 465
            :|.     |...:....|||:::.|||             |......|..:::|..|:|.|:.:.
Worm   558 MGALNPFMGNGALPFNPAAALSSLAAA-------------QAANAQRGSPANRSSRSSPSPHTNK 609

  Fly   466 SS-------SIKTE 472
            ||       .:|||
Worm   610 SSVSPGNNGHVKTE 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CtBP	NP_001262522.1	CtBP_dh	28..342	CDD:240624	182/317 (57%)
CtBP	NP_001262522.1	LdhA	45..351	CDD:223980	170/309 (55%)
ctbp-1	NP_001257030.1	THAP	4..>62	CDD:283206
		CtBP_dh	179..498	CDD:240624	183/318 (58%)
		SerA	206..507	CDD:223189	161/300 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166211
Domainoid	1	1.000	352	1.000	Domainoid score	I530
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	396	1.000	Inparanoid score	I1117
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D305212at33208
OrthoFinder	1	1.000	-	-		FOG0001579
OrthoInspector	1	1.000	-	-		oto17254
orthoMCL	1	0.900	-	-		OOG6_102736
Panther	1	1.100	-	-	LDO	PTHR46029
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3406
SonicParanoid	1	1.000	-	-		X1820
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.890