DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CtBP and CTBP2

DIOPT Version :9

Sequence 1:	NP_001262522.1	Gene:	CtBP / 41602	FlyBaseID:	FBgn0020496	Length:	481	Species:	Drosophila melanogaster
Sequence 2:	NP_073713.2	Gene:	CTBP2 / 1488	HGNCID:	2495	Length:	985	Species:	Homo sapiens

Alignment Length:	462	Identity:	279/462 - (60%)
Similarity:	333/462 - (72%)	Gaps:	49/462 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 LMMPKRSRIDVKGNFANGPLQARPLVALLDGRDCSIEMPILKDVATVAFCDAQSTSEIHEKVLNE 69
            ::.|:.|   ::....||||..||||||||||||::|||||||:|||||||||||.|||||||||
Human   554 MLAPEPS---IRPQIMNGPLHPRPLVALLDGRDCTVEMPILKDLATVAFCDAQSTQEIHEKVLNE 615

  Fly    70 AVGALMWHTIILTKEDLEKFKALRIIVRIGSGTDNIDVKAAGELGIAVCNVPGYGVEEVADTTMC 134
            ||||:|:|||.||:||||||||||:|||||||.||:|:||||||||||||:|...|||.||:|:|
Human   616 AVGAMMYHTITLTREDLEKFKALRVIVRIGSGYDNVDIKAAGELGIAVCNIPSAAVEETADSTIC 680

  Fly   135 LILNLYRRTYWLANMVREGKKFTGPEQVREAAHGCARIRGDTLGLVGLGRIGSAVALRAKAFGFN 199
            .|||||||..||...:|||.:....||:||.|.|.|||||:||||:|.||.|.|||:|||||||:
Human   681 HILNLYRRNTWLYQALREGTRVQSVEQIREVASGAARIRGETLGLIGFGRTGQAVAVRAKAFGFS 745

  Fly   200 VIFYDPYLPDGIDKSLGLTRVYTLQDLLFQSDCVSLHCTLNEHNHHLINEFTIKQMRPGAFLVNT 264
            ||||||||.|||::|||:.|||||||||:|||||||||.||||||||||:|||||||.||||||.
Human   746 VIFYDPYLQDGIERSLGVQRVYTLQDLLYQSDCVSLHCNLNEHNHHLINDFTIKQMRQGAFLVNA 810

  Fly   265 ARGGLVDDETLALALKQGRIRAAALDVHENEPYN---GALKDAPNLICTPHAAFFSDASATELRE 326
            |||||||::.||.|||:||||.|||||||:||::   |.||||||||||||.|::|:.::.|:||
Human   811 ARGGLVDEKALAQALKEGRIRGAALDVHESEPFSFAQGPLKDAPNLICTPHTAWYSEQASLEMRE 875

  Fly   327 MAATEIRRAIVGNIPDVLRNCVNKEYFMRTPPAAAAGGVAAAVYPEGLNGGYYTGALHHRAHSTT 391
            .|||||||||.|.||:.||||||||:|:.:.|.:...  ..|::|| |||..|.
Human   876 AAATEIRRAITGRIPESLRNCVNKEFFVTSAPWSVID--QQAIHPE-LNGATYR----------- 926

  Fly   392 PHDGPHSTTNLGSTVGGGPTTVAQAAAAAVAAAAAAALLPSPVP-SHLSPQVGGLPLGIVSSQSP 455
                 :....:|...||.|             ||...::|..:| :|..|.|.          .|
Human   927 -----YPPGIVGVAPGGLP-------------AAMEGIIPGGIPVTHNLPTVA----------HP 963

  Fly   456 LSAPDPN 462
            ..||.||
Human   964 SQAPSPN 970

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CtBP	NP_001262522.1	CtBP_dh	28..342	CDD:240624	238/316 (75%)
CtBP	NP_001262522.1	LdhA	45..351	CDD:223980	230/308 (75%)
CTBP2	NP_073713.2	CtBP_dh	574..892	CDD:240624	239/317 (75%)
CTBP2	NP_073713.2	SerA	590..900	CDD:223189	231/309 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	488	1.000	Domainoid score	I387
eggNOG	1	0.900	-	-		E1_COG0111
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H75187
Inparanoid	1	1.050	536	1.000	Inparanoid score	I1202
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60148
OrthoDB	1	1.010	-	-		D305212at33208
OrthoFinder	1	1.000	-	-		FOG0001579
OrthoInspector	1	1.000	-	-		otm40814
orthoMCL	1	0.900	-	-		OOG6_102736
Panther	1	1.100	-	-	LDO	PTHR46029
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3406
SonicParanoid	1	1.000	-	-		X1820
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.870