DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CtBP and Ctbp1

DIOPT Version :9

Sequence 1:	NP_001262522.1	Gene:	CtBP / 41602	FlyBaseID:	FBgn0020496	Length:	481	Species:	Drosophila melanogaster
Sequence 2:	NP_038530.1	Gene:	Ctbp1 / 13016	MGIID:	1201685	Length:	441	Species:	Mus musculus

Alignment Length:	481	Identity:	284/481 - (59%)
Similarity:	336/481 - (69%)	Gaps:	47/481 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDKNLMMPKRSRIDVKGNFANGPLQARPLVALLDGRDCSIEMPILKDVATVAFCDAQSTSEIHEK 65
            |..:.::.|...:.|:....|||:..||||||||||||::|||||||||||||||||||.|||||
Mouse     1 MGSSHLLNKGLPLGVRPPIMNGPMHPRPLVALLDGRDCTVEMPILKDVATVAFCDAQSTQEIHEK 65

  Fly    66 VLNEAVGALMWHTIILTKEDLEKFKALRIIVRIGSGTDNIDVKAAGELGIAVCNVPGYGVEEVAD 130
            ||||||||||:|||.||:||||||||||||||||||.||||:|:||:|||||||||...|||.||
Mouse    66 VLNEAVGALMYHTITLTREDLEKFKALRIIVRIGSGFDNIDIKSAGDLGIAVCNVPAASVEETAD 130

  Fly   131 TTMCLILNLYRRTYWLANMVREGKKFTGPEQVREAAHGCARIRGDTLGLVGLGRIGSAVALRAKA 195
            :|:|.||||||||.||...:|||.:....||:||.|.|.|||||:|||::||||:|.||||||||
Mouse   131 STLCHILNLYRRTTWLHQALREGTRVQSVEQIREVASGAARIRGETLGIIGLGRVGQAVALRAKA 195

  Fly   196 FGFNVIFYDPYLPDGIDKSLGLTRVYTLQDLLFQSDCVSLHCTLNEHNHHLINEFTIKQMRPGAF 260
            |||||:||||||.|||:::|||.||.|||||||.||||:|||.||||||||||:||:||||.|||
Mouse   196 FGFNVLFYDPYLSDGIERALGLQRVSTLQDLLFHSDCVTLHCGLNEHNHHLINDFTVKQMRQGAF 260

  Fly   261 LVNTARGGLVDDETLALALKQGRIRAAALDVHENEPYN---GALKDAPNLICTPHAAFFSDASAT 322
            |||||||||||::.||.|||:||||.|||||||:||::   |.||||||||||||||::|:.::.
Mouse   261 LVNTARGGLVDEKALAQALKEGRIRGAALDVHESEPFSFSQGPLKDAPNLICTPHAAWYSEQASI 325

  Fly   323 ELREMAATEIRRAIVGNIPDVLRNCVNKEYFMRTPPAAAAGGVAAAVYPEGLNGGYYTGALHHRA 387
            |:||.||.||||||.|.|||.|:|||||::.  |.....|....|.|:|| |||..|:..
Mouse   326 EMREEAAREIRRAITGRIPDSLKNCVNKDHL--TAATHWASMDPAVVHPE-LNGAAYSRY----- 382

  Fly   388 HSTTPHDGPHSTTNLGSTVGGGPTTVAQAAAAAVAAAAAAALLPSPVPSHLSPQVGGLPLGIVSS 452
                                  |..|...|...:.||....     |||.:|     |..|:...
Mouse   383 ----------------------PPGVVSVAPTGIPAAVEGI-----VPSAMS-----LSHGLPPV 415

  Fly   453 QSPLSAPDPNNHLSSSIKTEVKAEST 478
            ..|..||.|    ..::|.|...:.|
Mouse   416 AHPPHAPSP----GQTVKPEADRDHT 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CtBP	NP_001262522.1	CtBP_dh	28..342	CDD:240624	241/316 (76%)
CtBP	NP_001262522.1	LdhA	45..351	CDD:223980	233/308 (76%)
Ctbp1	NP_038530.1	Interaction with GLIS2 1	1..70		45/68 (66%)
		CtBP_dh	28..346	CDD:240624	242/317 (76%)
		Interaction with GLIS2 2	288..360		46/73 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	409..441		8/33 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	490	1.000	Domainoid score	I372
eggNOG	1	0.900	-	-		E1_COG0111
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	534	1.000	Inparanoid score	I1187
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60148
OrthoDB	1	1.010	-	-		D305212at33208
OrthoFinder	1	1.000	-	-		FOG0001579
OrthoInspector	1	1.000	-	-		otm42891
orthoMCL	1	0.900	-	-		OOG6_102736
Panther	1	1.100	-	-	O	PTHR46029
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3406
SonicParanoid	1	1.000	-	-		X1820
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.870