Protein Alignment MC4R and Rh6

DIOPT Version :10

• Sequence 1: NP_005903.2
• Gene: MC4R / 4160
• HGNCID: 6932
• Length: 332
• Species: Homo sapiens
• Sequence 2: NP_524368.5
• Gene: Rh6 / 41889
• FlyBaseID: FBgn0019940
• Length: 363
• Species: Drosophila melanogaster
• Alignment Length: 324
• Identity: 63/324 - (19%)
• Similarity: 112/324 - (34%)
• Gaps: 78/324 - (24%)

Human    50 VFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVS-------VSNGSETIVITLL 107
            |...||.:||..|.:|:.....:|.|.:|...|:.:||.:|.::.       |.||.....|
  Fly    53 VIAILGTMSLAGNFIVMYIFTSSKGLRTPSNMFVVNLAFSDFMMMFTMFPPVVLNGFYGTWI--- 114

Human   108 NSTDTDAQSFTVNIDNVIDSVI-CSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIIS 171
                  ...|...:..:..|:. |    .||.|:..||.|||..|...:. ...:|.....:.:.
  Fly   115 ------MGPFLCELYGMFGSLFGC----VSIWSMTLIAYDRYCVIVKGMA-RKPLTATAAVLRLM 168

Human   172 CIWAAC--------------------TVSGILFII--YSDSSAVIICLITMFFTMLALMASLYVH 214
            .:|..|                    |..|..:..  :.:.|.:|:..:.::.|.|..:...|.|
  Fly   169 VVWTICGAWALMPLFGWNRYVPEGNMTACGTDYFAKDWWNRSYIIVYSLWVYLTPLLTIIFSYWH 233

Human   215 MFLMARLHIK---------RIAVLPGTGAIRQGA-NMKGAITLTILIGVFVVCWAPF-------- 261
            :......|.|         .:|.|..:.|.:..| .:|.|......|.::...|.|:
  Fly   234 IMKAVAAHEKAMREQAKKMNVASLRNSEADKSKAIEIKLAKVALTTISLWFFAWTPYTIINYAGI 298

Human   262 --FLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLG 323
              .:||     .|.:..|..         :....|::.:|::|.|...:.::..:|.:.|...|
  Fly   299 FESMHL-----SPLSTICGS---------VFAKANAVCNPIVYGLSHPKYKQVLREKMPCLACG 348

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MC4R	NP_005903.2	7tmA_MC4R	45..313	CDD:320475	60/312 (19%)
		TM helix 1	46..72	CDD:320475	7/21 (33%)
		TM helix 2	79..105	CDD:320475	7/32 (22%)
		TM helix 3	122..152	CDD:320475	10/30 (33%)
		TM helix 4	164..184	CDD:320475	4/39 (10%)
		TM helix 5	189..218	CDD:320475	6/28 (21%)
		TM helix 6	238..268	CDD:320475	8/40 (20%)
		TM helix 7	281..306	CDD:320475	4/24 (17%)
Rh6	NP_524368.5	7tmA_photoreceptors_insect	48..338	CDD:320207	60/312 (19%)
		TM helix 1	49..75	CDD:320207	7/21 (33%)
		TM helix 2	82..108	CDD:320207	5/25 (20%)
		TM helix 3	120..150	CDD:320207	10/33 (30%)
		TM helix 4	161..181	CDD:320207	2/19 (11%)
		TM helix 5	208..237	CDD:320207	6/28 (21%)
		TM helix 6	267..297	CDD:320207	6/29 (21%)
		TM helix 7	306..331	CDD:320207	6/33 (18%)