DRSC/TRiP Functional Genomics Resources

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Protein Alignment MC4R and Rh6

DIOPT Version :9

Sequence 1:NP_005903.2 Gene:MC4R / 4160 HGNCID:6932 Length:332 Species:Homo sapiens
Sequence 2:NP_524368.5 Gene:Rh6 / 41889 FlyBaseID:FBgn0019940 Length:369 Species:Drosophila melanogaster


Alignment Length:324 Identity:63/324 - (19%)
Similarity:112/324 - (34%) Gaps:78/324 - (24%)


- Green bases have known domain annotations that are detailed below.


Human    50 VFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVS-------VSNGSETIVITLL 107
            |...||.:||..|.:|:.....:|.|.:|...|:.:||.:|.::.       |.||.....|   
  Fly    53 VIAILGTMSLAGNFIVMYIFTSSKGLRTPSNMFVVNLAFSDFMMMFTMFPPVVLNGFYGTWI--- 114

Human   108 NSTDTDAQSFTVNIDNVIDSVI-CSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIIS 171
                  ...|...:..:..|:. |    .||.|:..||.|||..|...:. ...:|.....:.:.
  Fly   115 ------MGPFLCELYGMFGSLFGC----VSIWSMTLIAYDRYCVIVKGMA-RKPLTATAAVLRLM 168

Human   172 CIWAAC--------------------TVSGILFII--YSDSSAVIICLITMFFTMLALMASLYVH 214
            .:|..|                    |..|..:..  :.:.|.:|:..:.::.|.|..:...|.|
  Fly   169 VVWTICGAWALMPLFGWNRYVPEGNMTACGTDYFAKDWWNRSYIIVYSLWVYLTPLLTIIFSYWH 233

Human   215 MFLMARLHIK---------RIAVLPGTGAIRQGA-NMKGAITLTILIGVFVVCWAPF-------- 261
            :......|.|         .:|.|..:.|.:..| .:|.|......|.::...|.|:        
  Fly   234 IMKAVAAHEKAMREQAKKMNVASLRNSEADKSKAIEIKLAKVALTTISLWFFAWTPYTIINYAGI 298

Human   262 --FLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLG 323
              .:||     .|.:..|..         :....|::.:|::|.|...:.::..:|.:.|...|
  Fly   299 FESMHL-----SPLSTICGS---------VFAKANAVCNPIVYGLSHPKYKQVLREKMPCLACG 348

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MC4RNP_005903.2 7tmA_MC4R 45..313 CDD:320475 60/312 (19%)
TM helix 1 46..72 CDD:320475 7/21 (33%)
TM helix 2 79..105 CDD:320475 7/32 (22%)
TM helix 3 122..152 CDD:320475 10/30 (33%)
TM helix 4 164..184 CDD:320475 4/39 (10%)
TM helix 5 189..218 CDD:320475 6/28 (21%)
TM helix 6 238..268 CDD:320475 8/40 (20%)
TM helix 7 281..306 CDD:320475 4/24 (17%)
Rh6NP_524368.5 7tmA_photoreceptors_insect 48..338 CDD:320207 60/312 (19%)
TM helix 1 50..74 CDD:320207 7/20 (35%)
TM helix 2 83..105 CDD:320207 4/21 (19%)
TM helix 3 121..143 CDD:320207 6/25 (24%)
TM helix 4 165..181 CDD:320207 2/15 (13%)
TM helix 5 209..232 CDD:320207 4/22 (18%)
TM helix 6 273..295 CDD:320207 4/21 (19%)
TM helix 7 306..331 CDD:320207 6/33 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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