DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MC4R and Dop1R1

DIOPT Version :9

Sequence 1:	NP_005903.2	Gene:	MC4R / 4160	HGNCID:	6932	Length:	332	Species:	Homo sapiens
Sequence 2:	NP_001262563.1	Gene:	Dop1R1 / 41726	FlyBaseID:	FBgn0011582	Length:	560	Species:	Drosophila melanogaster

Alignment Length:	393	Identity:	105/393 - (26%)
Similarity:	168/393 - (42%)	Gaps:	118/393 - (30%)

- Green bases have known domain annotations that are detailed below.

Human    11 TSLHLWNRSSYRLHSNASES---LGKGYSDGGCYEQLFVSPE-----VFVTLGV-------ISLL 60
            |....:|.||:   :||||.   :|:             .||     ..|.:|:       :|:.
  Fly    96 TLTSFYNESSW---TNASEMDTIVGE-------------EPEPLSLVSIVVVGIFLSVLIFLSVA 144

Human    61 ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDT------DAQSFTV 119
            .||||.:||...::|......|:.|||:||:.|:      ::|:|.....|.      .||.
  Fly   145 GNILVCLAIYTERSLRRIGNLFLASLAIADLFVA------SLVMTFAGVNDLLGYWIFGAQF--- 200

Human   120 NIDN-VIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGII-ISCIW-AACTVSG 181
             .|. |...|:||:  |||.:|.:|::|||..|...|:|...:| :||.:| |:.|| .|..||.
  Fly   201 -CDTWVAFDVMCST--ASILNLCAISMDRYIHIKDPLRYGRWVT-RRVAVITIAAIWLLAAFVSF 261

Human   182 ILF----------IIYSDSS--------------AVIICLITMFFTMLALMASLYVHMFLMARLH 222
            :..          :|:.|:.              ||:...|:.:|..: :|..:|..::..|:.|
  Fly   262 VPISLGIHRPDQPLIFEDNGKKYPTCALDLTPTYAVVSSCISFYFPCV-VMIGIYCRLYCYAQKH 325

Human   223 IKRIAVL--PGTGA-------IRQGANM---------------------KGAITLTILIGVFVVC 257
            :|.|..:  ||..|       ||:..|.                     |.|:|:.:::|||::|
  Fly   326 VKSIKAVTRPGEVAEKQRYKSIRRPKNQPKKFKVRNLHTHSSPYHVSDHKAAVTVGVIMGVFLIC 390

Human   258 WAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEII----- 317
            |.|||...|....|..   |:...: |.:...|...||..:|:||::.::|.|..||.|:
  Fly   391 WVPFFCVNITAAFCKT---CIGGQT-FKILTWLGYSNSAFNPIIYSIFNKEFRDAFKRILTMRNP 451

Human   318 -CC 319
             ||
  Fly   452 WCC 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MC4R	NP_005903.2	7tmA_MC4R	45..313	CDD:320475	91/342 (27%)
		TM helix 1	46..72	CDD:320475	11/37 (30%)
		TM helix 2	79..105	CDD:320475	8/25 (32%)
		TM helix 3	122..152	CDD:320475	13/30 (43%)
		TM helix 4	164..184	CDD:320475	9/21 (43%)
		TM helix 5	189..218	CDD:320475	7/42 (17%)
		TM helix 6	238..268	CDD:320475	13/50 (26%)
		TM helix 7	281..306	CDD:320475	7/24 (29%)
Dop1R1	NP_001262563.1	7tm_4	134..>266	CDD:304433	46/144 (32%)
Dop1R1	NP_001262563.1	7tm_1	145..431	CDD:278431	82/303 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910