Protein Alignment MC4R and 5-HT1B

DIOPT Version :9

• Sequence 1: NP_005903.2
• Gene: MC4R / 4160
• HGNCID: 6932
• Length: 332
• Species: Homo sapiens
• Sequence 2: NP_001137708.2
• Gene: 5-HT1B / 37191
• FlyBaseID: FBgn0263116
• Length: 629
• Species: Drosophila melanogaster
• Alignment Length: 575
• Identity: 99/575 - (17%)
• Similarity: 163/575 - (28%)
• Gaps: 299/575 - (52%)

Human    15 LWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVF---------VTLG---VISLLENILVIV 67
            :||||   ::.|.:.:......|    ||...:.|.:         |.||   :::::.|:.||.
  Fly    56 VWNRS---INGNGNSNTFDLVDD----EQERAAVEFWLLVKMIAMAVVLGLMILVTIIGNVFVIA 113

Human    68 AIAKNKNLHSPMYFFICSLAVADMLVS-----------VSNGSETIVITLLNSTDTDAQSFTVNI 121
            ||...:||.:...:.:.||||||:.|:           :|||      .:|.....|       |
  Fly   114 AIILERNLQNVANYLVASLAVADLFVACLVMPLGAVYEISNG------WILGPELCD-------I 165

Human   122 DNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGIL--- 183
            ....|.:.|:   |||..|::||.|||:|: ..:.|:|:.|.:||.::|.|:|.|..:..:.
  Fly   166 WTSCDVLCCT---ASILHLVAIAADRYWTV-TNIDYNNLRTPRRVFLMIFCVWFAALIVSLAPQF 226

Human   184 ---------------FIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKR-------- 225
                           .::..|....|......|:..|.::..||..::::||..|:|
  Fly   227 GWKDPDYMKRIEEQHCMVSQDVGYQIFATCCTFYVPLLVILFLYWKIYIIARKRIQRRAQKSFNV 291

Human   226 ----------------------------------------------------------------- 225
                                                                             
  Fly   292 TLTETDCDSAVRELKKERSKRRAERKRLEAGERTPVDGDGTGGQLQRRTRKRMRICFGRNTNTAN 356

Human   226 ---------------IAV----------------------------------------------- 228
                           |||
  Fly   357 VVAGSEGAVARSMAAIAVDFASLAITREETEFSTSNYDNKSHAGTELTTVSSDADDYRTSNANEI 421

Human   229 -----------------------------------------------LPGTGAI----------- 235
                                                           |.|.|.:
  Fly   422 ITLSQQVAHATQHHLIASHLNAITPLAQSIAMGGVGCLTTTTPSEKALSGAGTVAGAVAGGSGSG 486

Human   236 --RQGANMKG------------------------------------AITLTILIGVFVVCWAPFF 262
              .:||..:|                                    |.||.|:.|.||:||.|||
  Fly   487 SGEEGAGTEGKNAGVGLGGVLASIANPHQKLAKRRQLLEAKRERKAAQTLAIITGAFVICWLPFF 551

Human   263 LHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEII 317
            :..:....|.:   |....:..:|:|.|...||.::|:||.:.:.|.|:.||.|:
  Fly   552 VMALTMSLCKE---CEIHTAVASLFLWLGYFNSTLNPVIYTIFNPEFRRAFKRIL 603

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MC4R	NP_005903.2	7tmA_MC4R	45..313	CDD:320475	88/539 (16%)
		TM helix 1	46..72	CDD:320475	9/37 (24%)
		TM helix 2	79..105	CDD:320475	10/36 (28%)
		TM helix 3	122..152	CDD:320475	12/29 (41%)
		TM helix 4	164..184	CDD:320475	6/37 (16%)
		TM helix 5	189..218	CDD:320475	6/28 (21%)
		TM helix 6	238..268	CDD:320475	15/65 (23%)
		TM helix 7	281..306	CDD:320475	8/24 (33%)
5-HT1B	NP_001137708.2	7tm_1	107..>288	CDD:278431	51/197 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910