DRSC/TRiP Functional Genomics Resources

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Protein Alignment MC4R and aexr-2

DIOPT Version :9

Sequence 1:NP_005903.2 Gene:MC4R / 4160 HGNCID:6932 Length:332 Species:Homo sapiens
Sequence 2:NP_001359893.1 Gene:aexr-2 / 259709 WormBaseID:WBGene00016090 Length:433 Species:Caenorhabditis elegans


Alignment Length:344 Identity:71/344 - (20%)
Similarity:126/344 - (36%) Gaps:101/344 - (29%)


- Green bases have known domain annotations that are detailed below.


Human    28 SESLGKGYSDGGC-YEQLFV-----SPEVFVTLGVISLLENILVIVAIAK-NKNLHSPMYFFICS 85
            |.|....||   | |...|:     ..:|.:...:||.:.|.:||...|| .|.....::.||.:
 Worm    34 SSSEAMQYS---CYYSDSFIRFATAMDDVLIGACLISTVINFIVIACSAKLYKKKGDTLHLFILN 95

Human    86 LAVADMLVSV-----------SNGSETIVITL-LNSTD-----TDAQSFT-VNIDNVI------- 125
            :.:.|.::::           .:|:....||: ||..:     ....|.| :|||.:|       
 Worm    96 MTIGDTILTLFCHPYELVTRRYSGAHVHFITVFLNFANWVGLAVSGLSLTLLNIDKLIFFCWPFK 160

Human   126 ----DSVICSSLLASICSLLSIAVDRYFTIFYALQYHN----------IMTVKRVGIIISCIWAA 176
                .|...:.|...:..::||....|:.::..:.:.|          |..|...|::.|..:: 
 Worm   161 YDIWMSYFRAKLFCYLSWIISIGFATYYWMYSYMYFVNATVDIQQQFEIQFVFLTGLMNSGQFS- 224

Human   177 CTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGA--IRQGA 239
             .|:.|.:.::           |:.|.::.:::||.|..:|......||..|:..:.|  |...|
 Worm   225 -PVNKIFYEVF-----------TVVFCVIPIVSSLLVSCYLYDLTKRKRKTVIKTSSASKIENKA 277

Human   240 NMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNL------------------ 286
            .....|..|.|       |.          ||...||.:..::..::                  
 Worm   278 TSFAFIFATTL-------WT----------SCSLLPYRIANLARIHIIAWPNLDCESRQNLSWLT 325

Human   287 --YLILIMCNSIIDPLIYA 303
              .|.|::.|.||:|||.|
 Worm   326 WSMLYLLILNPIINPLITA 344

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
MC4RNP_005903.2 7tmA_MC4R 45..313 CDD:320475 65/326 (20%)
TM helix 1 46..72 CDD:320475 8/31 (26%)
TM helix 2 79..105 CDD:320475 4/36 (11%)
TM helix 3 122..152 CDD:320475 7/40 (18%)
TM helix 4 164..184 CDD:320475 4/19 (21%)
TM helix 5 189..218 CDD:320475 5/28 (18%)
TM helix 6 238..268 CDD:320475 5/29 (17%)
TM helix 7 281..306 CDD:320475 9/43 (21%)
aexr-2NP_001359893.1 7tm_classA_rhodopsin-like 59..342 CDD:381740 61/312 (20%)
TM helix 1 59..80 CDD:381740 6/20 (30%)
TM helix 2 90..112 CDD:381740 3/21 (14%)
TM helix 3 127..149 CDD:381740 4/21 (19%)
TM helix 4 172..188 CDD:381740 3/15 (20%)
TM helix 5 228..247 CDD:381740 3/29 (10%)
TM helix 6 277..302 CDD:381740 9/41 (22%)
TM helix 7 322..342 CDD:381740 6/19 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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