Protein Alignment CG7518 and FAM193A

DIOPT Version :10

• Sequence 1: NP_731761.3
• Gene: CG7518 / 41599
• FlyBaseID: FBgn0038108
• Length: 2464
• Species: Drosophila melanogaster
• Sequence 2: XP_011511892.2
• Gene: FAM193A / 8603
• HGNCID: 16822
• Length: 1565
• Species: Homo sapiens
• Alignment Length: 1798
• Identity: 333/1798 - (18%)
• Similarity: 548/1798 - (30%)
• Gaps: 650/1798 - (36%)

  Fly    46 ADAEGDVDATASSSCVATASQLNPSPPPAGVQQAKPARSSSPPCQLL--ER--LSFPDGNIINTL 106
            |.|.|.:.|.||:...|...... :|...|:....|...:...|.|.  ||  .||.:..|....
Human    63 AAANGPLGAGASAGGAAPGGYFE-TPFSFGMNHRTPPYPAGDYCLLCRSERKDSSFLESGIKTAS 126

  Fly   107 HTILALPPFDPYAPAPKAETVYKEVVSLMQW----------SQREDNAIELELS-DKLLHECEHK 160
            ...|::        |||..:    |:.|..|          .:.....::..:| |.|||  ...
Human   127 KLALSM--------APKGNS----VLHLPLWVCPDCRRTVEKEERHGGLDQPVSQDFLLH--SSL 177

  Fly   161 GGDPNDETRSYLMAIENMRLFSEDPKNPLRDADGQLRAITLYFQNLAFIFVKHRKEEFFTFCSCK 225
            ||...:......:|:....|.|:                                    |.|||:
Human   178 GGSQPEAGSGGRLALGAQTLPSD------------------------------------TACSCE 206

  Fly   226 ECLEYRETIMAIMMDQFKAAHMVVMLLDVLIKAYSPMLKNDAAYNKFEKLLECNKE-----IYWI 285
            .|.|.||                       |.|                  |.::|     .||.
Human   207 ACSERRE-----------------------ISA------------------EADREPQQLQNYWS 230

  Fly   286 TSGY----LYDKNAEYL-DFIDDTAISDNMILVLFSAILMANNPMLLLQ---------ILAYNVE 336
            ...|    :|.:....| |..|.:.:.|...:......|...:|..|.|         :|...|.
Human   231 EVRYTVRCIYRQAGTPLADDQDQSLVPDKEGVKELVDRLCERDPYQLYQRLEQQAREYVLEMKVR 295

  Fly   337 CIVKAFSEGMIEIAQNIQENEKISAERMLTYILDGYSDLNCISQKISLSLFAFENDFLRKFRLSW 401
            .:.:..:...::....:|...:  |.:.::.:|:.|..|...::.||..|...||:.|:||:::|
Human   296 LLRQLSAAAKVKAPSGLQGPPQ--AHQFISLLLEEYGALCQAARSISTFLGTLENEHLKKFQVTW 358

  Fly   402 VLLCQRLFQQHVFT-PLGDTMLACILSLKEVAPSAQTT-------ALIKRYMLFDEHMHSIERRW 458
            .|..:.||:..||: ||..:.|..::|...:..:...|       .|::||...:|.:    ||.
Human   359 ELHNKHLFENLVFSEPLLQSNLPALVSQIRLGTTTHDTCSEDTYSTLLQRYQRSEEEL----RRV 419

  Fly   459 TDIWIELNKFNLSPTEHERRM---------------------GLLDVYNIFDKVV---------L 493
            .:.|:|..| .:.....|:|:                     |..|:....:|.:         |
Human   420 AEEWLECQK-RIDAYVDEQRLSCCGLSLTSDFLAWTTVRAGSGCQDLQTSVNKSIDTGTLVQSWL 483

  Fly   494 DATSFSLPD----ISDD-EFIDFQRIVDRQLAWKNI-------------MAFTKLKWPDGFYDPP 540
            ...:.::..    :::| |....:|.::.||..|..             |..::|..||
Human   484 RGAAMTMKTKQRMLTEDWELFKQRRFIEEQLTNKKAVTGENNFTDTMRHMLSSRLSMPD------ 542

  Fly   541 NKLVHEDLCKKCNSLLEHHNENCKC--------ITCSIAGTPLR--------PRQ---------- 579
                    |..||     :...|.|        :||.|...|:.        |.|
Human   543 --------CPNCN-----YRRRCACDDCSLSHILTCGIMDPPVTDDIHIHQLPLQVDPAPDYLAE 594

  Fly   580 ------------AGHCAKCTTLGIVEKDPKLMKSKILST---CTSDE------AK---------- 613
                        :|..:..|    :::.|:|:.:...|.   |:.||      ||
Human   595 RSPPSVSSASSGSGSSSPIT----IQQHPRLILTDSGSAPTFCSDDEDVAPLSAKFADIYPLSNY 655

  Fly   614 --------------------HNAAI------AATTSSSTSTAQQQRRTSD-------LPEDESPT 645
                                .|.|:      .::||||:|.|..:....:       .|:::...
Human   656 DDTEVVANMNGIHSELNGGGENMALKDESPQISSTSSSSSEADDEEADGESSGEPPGAPKEDGVL 720

  Fly   646 GSGSSGSVFRRQAETSDTLRTTY--------------HIAWAVFQHLATRKRYRHETIEP--QFI 694
            ||.|.    |.:...:|:...:|              |:.......| |........:.|  ||:
Human   721 GSRSP----RTEESKADSPPPSYPTQQAEQAPNTCECHVCKQEASGL-TPSAMTAGALPPGHQFL 780

  Fly   695 CGENCRVSACQLARKILSNQLSPLLTKYLLRCFQPLSFTREELRSTIPSLMFFNRKLAPSPAELQ 759
            ..|.....|..|...|..:  .||.|...|    |.......|.:|.|   |.:.|..| ||.:|
Human   781 SPEKPTHPALHLYPHIHGH--VPLHTVPHL----PRPLIHPTLYATPP---FTHSKALP-PAPVQ 835

  Fly   760 ELRNQHYVYKTYWTFVLSIYANFF---VKFNSSSTDFGHLELIKGDLRLRLNSVVGDKEDNRFEQ 821
            ...|:|.|:..  :....||.:.|   .::|||..           :.|..:.|:.||..|. ..
Human   836 NHTNKHQVFNA--SLQDHIYPSCFGNTPEWNSSKF-----------ISLWGSEVMNDKNWNP-GT 886

  Fly   822 FLAQVIGYSPFKVTDDFTLGDANIEKLQFGVDQLMMLHDSQIIKRTKPDSTTGLSGAKSKLGESN 886
            ||...|..|..       ||..                    :..|:|              |:.
Human   887 FLPDTISGSEI-------LGPT--------------------LSETRP--------------EAL 910

  Fly   887 VPQSGGKNGEAGGNKKSKE-KMRKCCSDYADIGEPCKE-----NHSKKRVKKECNHARFNETRDR 945
            .|.|..:......:|:.|. ..:||..::.|......:     :.:...|.......:.:.::.|
Human   911 PPPSSNETPAVSDSKEKKNAAKKKCLYNFQDAFMEANKVVMATSSATSSVSCTATTVQSSNSQFR 975

  Fly   946 LRKK----LSQIVNERKTKSTEETTPSKTKCS----KPEPVAVPA---PAAIPPKRPP------- 992
            :..|    :..:.:....:....:.|:..:.|    .|.|...||   |||:.|...|
Human   976 VSSKRPPSVGDVFHGISKEDHRHSAPAAPRNSPTGLAPLPALSPAALSPAALSPASTPHLANLAA 1040

  Fly   993 -----------------SPFNPPKLPAVL--AVAALDRICR----EEH----------EDDSLLR 1024
                             ..|.|..||...  :::|...:|.    |.|          :||....
Human  1041 PSFPKTATTTPGFVDTRKSFCPAPLPPATDGSISAPPSVCSDPDCEGHRCENGVYDPQQDDGDES 1105

  Fly  1025 LDSLCKSLQRHTDATDAS--------AAAAALAAFKHGSGFPADYSKEDMMQDFAEFLGTYTYTR 1081
            .|.  .|...|:.:|..|        ........|.|| |.||..:..: ..:..|.|......|
Human  1106 ADE--DSCSEHSSSTSTSTNQKEGKYCDCCYCEFFGHG-GPPAAPTSRN-YAEMREKLRLRLTKR 1166

  Fly  1082 EQDQ---------------QRWINETLNFIEGKSQQPHTANPKKAAKKAKQKMRK---------- 1121
            :::|               .|.:.:.|.||.....:|  .:..:|||:|:.|.||
Human  1167 KEEQPKKMDQISERESVVDHRRVEDLLQFINSSETKP--VSSTRAAKRARHKQRKLEEKARLEAE 1229

  Fly  1122 ---------EEEKRIKELEDLRCQFLDIYFKEFIDKYEMKTLTAAGGRKKEK--KRIGELETNIK 1175
                     :||:|.:|.|:...:..|.:.:||....|::.|.|...:|||:  |...:|:...:
Human  1230 ARAREHLHLQEEQRRREEEEDEEEEEDRFKEEFQRLQELQKLRAVKKKKKERPSKDCPKLDMLTR 1294

  Fly  1176 NLQRAKAKVETVILELIATVKQTNSEFKFSYLPTKQQQLAKMAQLEEILNGGPTTATAEPVRQEP 1240
            |.|.|...|..                      :.......:.|.||     |.|::..|.|.
Human  1295 NFQAATESVPN----------------------SGNIHNGSLEQTEE-----PETSSHSPSRH-- 1330

  Fly  1241 PQQSAPQYPEFSSNASFYHPPGLGQQNTPVCFAPPQQSQHPPQLSRDVIAAMAASSITADPSKRI 1305
            ...|.|:             ||||                             |....|||
Human  1331 MNHSEPR-------------PGLG-----------------------------ADGDAADP---- 1349

  Fly  1306 VTIR--RVQLPHPGAEQQVTVVAKGSAPHED-KLLYTFVNGHMVASGPIQPEEMAPRQATVPAPA 1367
            |..|  :..||.....:|          ||. ...:..:..|...:|. |......:.::.||..
Human  1350 VDTRDSKFLLPKEVNGKQ----------HEPLSFFFDIMQHHKEGNGK-QKLRQTSKASSEPARR 1403

  Fly  1368 PSVPEKSAKAKKKEAKRAAAAAAAEAAAAAEAAAAAAAEAAAEQKAKL-------KNKKQAKKTA 1425
            |:.|.|:.:.:.|                        ..|..|.|||:       :.|::.:|
Human  1404 PTEPPKATEGQSK------------------------PRAQTESKAKVVDLMSITEQKREERK-- 1442

  Fly  1426 VAVATASSSTASSNSSKSQTPQSTRESSVCSVKPKTVPKKPTS-----KPPKVVEVTPPPPVPEP 1485
                     ..|:|::|.|.      :.:...|....|.:|||     :..|:|....|.|..:.
Human  1443 ---------VNSNNNNKKQL------NHIKDEKSNPTPMEPTSPGEHQQNSKLVLAESPQPKGKN 1492

  Fly  1486 EPEPPKRQKRLKSRLD----PGQLDNNPWKALHMQDSSEGEWE 1524
            :....|:..|:.:.:|    |..:|      |...|..|.|.|
Human  1493 KKNKKKKGDRVNNSIDDVFLPKDID------LDSVDMDETERE 1529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7518	NP_731761.3	None
FAM193A	XP_011511892.2	PRK12323	<1002..>1079	CDD:481241	15/76 (20%)
		FAM193_C	1509..1564	CDD:464940	7/27 (26%)