DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7518 and fam193b

DIOPT Version :9

Sequence 1:	NP_731761.3	Gene:	CG7518 / 41599	FlyBaseID:	FBgn0038108	Length:	2464	Species:	Drosophila melanogaster
Sequence 2:	XP_697699.4	Gene:	fam193b / 569234	ZFINID:	ZDB-GENE-111102-1	Length:	922	Species:	Danio rerio

Alignment Length:	1047	Identity:	200/1047 - (19%)
Similarity:	327/1047 - (31%)	Gaps:	387/1047 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   612 AKHNAAIAATTSSSTSTAQQQRRTSDLPED----ESPTGSGSSGSVFRRQAETSDTLRTTYHIAW 672
            |:..:....|.:..:.:.|||:..|..|.|    .:.||.|.:|:     |.||.::.|...:..
Zfish     2 ARKKSKQQGTGAKDSVSVQQQQSLSKKPGDAVAGAAATGGGDAGA-----ARTSQSMHTCCLLCH 61

  Fly   673 AVFQH--------LATRKRYRHETIE------------------------------PQFICGENC 699
            ..|:.        |........|.:.                              |.:|| ::|
Zfish    62 REFKDWGSGGANGLPAHGSRLAEAVPALSQALLRDAPGRTLADAVPSLSQSLLGEVPLWIC-QSC 125

  Fly   700 RVSACQLARKILSNQLSPLLTKYLLRCFQPLSFTREELRSTI---PSLMFFNRKLA--------- 752
            |.|..:..|:.|..|.|.:...:...|............|::   ||.....|||:
Zfish   126 RRSVEEEERRTLQEQNSQVPLSHSSSCKSQSCGNGYPENSSVDWDPSSFLSARKLSGLWNSAHSN 190

  Fly   753 ------PSPAEL----------QELRNQH----YVYKTYWTFVLSIYANFFVKFNSSSTDFGHLE 797
                  .:||.|          .|.|..|    ...||:.|.|.. |:: ....|||:...|.|
Zfish   191 GGSHCNHNPAALSPGGTLGPACHEKRPSHDAPGKAAKTFGTKVCP-YSH-PASQNSSAASPGTL- 252

  Fly   798 LIKGDLRLRLNSVVGDKEDNRFEQFLAQVIGYSP----FKVTDDFTLGDANIEKLQFGVDQLMML 858
                       |...|......:.|.......:|    |...|.....|.::
Zfish   253 -----------SASSDACKTNPKHFKTMCRRPTPPGEAFHPNDHHQSADLSV------------- 293

  Fly   859 HDSQIIKRTKPDSTTGLSGAKSKLGESNVP--QSGGKNGEAGGNKKSKEKMRKCCSDYADIGEPC 921
                     .|:|.||||...|.|    :|  |:..::...|.               |:.|.|
Zfish   294 ---------PPNSPTGLSSQHSSL----LPPKQNSSQHVHVGS---------------ANSGLP- 329

  Fly   922 KENHSKKRVKKECNHARFNETRDRLRKKLSQIVNERKTKSTEETTPSKTKCSKPE-PVAVPAPAA 985
                         :||.|:.....:.                  .|:....|.|: |||:..|:|
Zfish   330 -------------SHAPFSPLVPNIH------------------APTAKHSSGPDSPVALHKPSA 363

  Fly   986 IPPKRPPS-----------------PFN---------PPKLPAVLAVAALDRICREEHEDDSLLR 1024
            ......|:                 |.|         .|....|...|..|:.|:.....:.
Zfish   364 CKNAHIPAVNSQHGKLSNSLIGCSHPCNGHSNGSSVASPNAGHVTPGACRDQACKGHKVPNG--- 425

  Fly  1025 LDSLCKSLQRHT--------DATDASAAAAALAAFKHGSGFPADYSKEDMMQD--FAEFLG---- 1075
              |||     ||        |..|:|:..::.|:       .::..|:....|  :.||.|
Zfish   426 --SLC-----HTSPCELEEGDDEDSSSERSSCAS-------SSNNQKDGKYCDCCYCEFFGHNAP 476

  Fly  1076 -------TYTYTRE----------------QD---------QQRWINETLNFIEGKSQQPHTANP 1108
                   .|...||                ||         ..|.::|.|:||  .|.:|...|.
Zfish   477 PAAPTSRNYAEIREKLRSRLTRRKEELPQRQDLDPAAPSAIDHRDVDELLDFI--NSTEPKPVNS 539

  Fly  1109 KKAAKKAKQKMRKEEEKRIKELEDLRCQFLDIYFKEFIDKYEMKTLTAAGGRKKEKKRIGELETN 1173
            .||||:|:.|.:|:|::|.     |:|                 ::.|.|...:.......:|.:
Zfish   540 AKAAKRARHKQKKKEKERA-----LQC-----------------SMDAVGSDPRSASPPDPMEDS 582

  Fly  1174 IKNLQRAKAKVETVILELIATVKQTNSEFKFSYLPTKQQQLAKMAQLEEILNGGPTTATAEPVR- 1237
            ..:.. |...:|...|||    ::.|     |:|.::         ||||.|     ...:.:|
Zfish   583 APDAD-ANRLLEWPQLEL----ERVN-----SFLTSR---------LEEIKN-----TIKDSIRA 623

  Fly  1238 -----------QEPPQQSAPQYPEFSSNASFYHPPGLGQ-QNTPVCFAPPQQSQHPPQLSRDVIA 1290
                       .:.|:::|    ....|....|..|... |...:..||.........|  |::.
Zfish   624 SFSMYDLNLDVNDFPKKAA----TLEGNHLLSHLNGSSDLQQIDLDLAPLSLRNFKRDL--DIVN 682

  Fly  1291 AMAASSITADPSKRIVTIRRVQLPHPGAEQQVTVVAKGSAPHEDKLLYTFVNGHMVASGPIQPEE 1355
            ....::..|...:|:         |             |.|...||:       .|.|    ||.
Zfish   683 GWEDTTTAAKDIQRL---------H-------------STPSLSKLI-------RVRS----PER 714

  Fly  1356 MAPRQATVPA--PAPSVPE-KS-AKAKKKEAKRAAAAAAAEAAAAAEAAAAAAAEAAAEQKAKL- 1415
            :...::|..|  |..::|| || |.||.|::|:....:...:...|:...||..:.:.:...|.
Zfish   715 IPAPESTQSAAKPGEALPEIKSLAGAKMKKSKKQQEVSGKSSTHKAQEIKAADCDKSTKGGCKTQ 779

  Fly  1416 -----KN-KKQAKKTAVAVATASS---STASSNSSKSQTPQSTRESSVCSVKP------KTVPKK 1465
                 || .|:|::..|...|:|:   :||::...:::...|....|    :|      |::...
Zfish   780 QVDAQKNGNKKAEEVKVCKQTSSNGHHNTATNTQQRAKNELSDTRGS----RPEHDGDTKSISNT 840

  Fly  1466 PTSKPPK 1472
            |:::.||
Zfish   841 PSAQQPK 847

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
CG7518	NP_731761.3	None
fam193b	XP_697699.4	FAM193_C	867..915	CDD:292536
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596536
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR15109
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.030