Protein Alignment CG7518 and Fam193a

DIOPT Version :9

• Sequence 1: NP_731761.3
• Gene: CG7518 / 41599
• FlyBaseID: FBgn0038108
• Length: 2464
• Species: Drosophila melanogaster
• Sequence 2: NP_001230052.1
• Gene: Fam193a / 231128
• MGIID: 2447768
• Length: 1518
• Species: Mus musculus
• Alignment Length: 1748
• Identity: 319/1748 - (18%)
• Similarity: 531/1748 - (30%)
• Gaps: 643/1748 - (36%)

  Fly    70 SPP-PAGVQQAKPARSSSPPCQLLE---------RLSF-PDGNIINTLHTILALPPFDPYAPAPK 123
            :|| ||| ......||.......||         .||. |.||  :.||..|.:.|       ..
Mouse    85 TPPYPAG-DYCLLCRSERKDSSFLESGVKTASKLALSMAPKGN--SVLHLPLWVCP-------DC 139

  Fly   124 AETVYKEVVSLMQWSQREDNAIELELSDKLLHECEHKGGDPNDETRSYLMAIENMRLFSEDPKNP 188
            ..||.||        :|.....:.:..|.|||  ...||...:.:.:..:|:....:.|......
Mouse   140 RRTVEKE--------ERHSGLDQPQGQDFLLH--SSLGGSQPETSGAGRLALGTQTMTSSGLGTT 194

  Fly   189 LRDADGQLRAITLYFQNLAFIFVKHRKEEFFTFCSCKECLEYRETIMAIMMDQFKAAHMVVMLLD 253
            ..||                             |||:.|.|.|:                   :.
Mouse   195 PSDA-----------------------------CSCEACSERRD-------------------IS 211

  Fly   254 VLIKAYSPMLKNDAAYNKFEKLLECNKEIYWITSGYLY-----DKNAEYLDFIDDTAISDNMILV 313
            ...:.....|:|                 ||....|:.     .......:..|.:.:.|...:.
Mouse   212 AETEREPQQLQN-----------------YWSEVRYMVRCIYRQAGTPLAEDQDQSLVPDKEGVK 259

  Fly   314 LFSAILMANNPMLLLQ---------ILAYNVECIVKAFSEGMIEIAQNIQENEKISAERMLTYIL 369
            .....|...:|..|.|         :|...|..:.:..:....:....:|...:  |...::.:|
Mouse   260 ELVDRLCERDPYQLYQRLEQQAREYVLEMKVRLLRQLSAAAKAKAPSGLQGPPQ--AHHFVSLLL 322

  Fly   370 DGYSDLNCISQKISLSLFAFENDFLRKFRLSWVLLCQRLFQQHVFT-PLGDTMLACILSLKEVAP 433
            :.|:.|...::.||..|...||:.|:||:::|.|..:.||:..||: ||..:.|..::|...:..
Mouse   323 EEYAALCQAARSISTFLGTLENEHLKKFQVTWELHNKHLFENLVFSEPLLQSNLPALVSQIRLGT 387

  Fly   434 SAQTT-------ALIKRYMLFDEHMHSIERRWTDIWIELNKFNLSPTEHERRMGLLDVYNIFDKV 491
            :...|       .|::||...:|.:    |:..:.|:|..|             .:|.| :.:::
Mouse   388 TTHDTCTEDMYSTLLQRYQRSEEEL----RKVAEEWLECQK-------------RIDAY-VDEQM 434

  Fly   492 VLDATSFSLPDISDDEFIDFQRIVDRQLAWKNI-------------MAFTKLKWPDGFYDPPNKL 543
            .:......|.:  |.|....:|:::.||..|.:             |..::|..||
Mouse   435 TMKTKQRMLTE--DWEIFKQRRLIEEQLTNKKVVTGENNFTDTRRHMLSSRLSMPD--------- 488

  Fly   544 VHEDLCKKCNSLLEHHNENCKC--------ITCSIAGTP-----------------------LRP 577
                 |..||     :...|.|        :||.|..||                       :||
Mouse   489 -----CPNCN-----YRRRCACDDCSLSHILTCGIMDTPVTDDIHIHQLPLQVDSAPDYLSEMRP 543

  Fly   578 RQ-------AGHCAKCTTLGIVEKDPKLM---KSKILSTCTSDE------AK------------- 613
            ..       :|..:..|    :::.|:|:   .....:.|:.||      ||
Mouse   544 PSVSSASSGSGSSSPIT----IQQHPRLILTDNGSAPTFCSDDEDVAPLSAKFADIYPLTNYDDT 604

  Fly   614 -----------------HNAAI------AATTSSSTSTAQQQRRTSD-------LPEDESPTGSG 648
                             .|.|:      .::||.|:|.|..:....:       .|:.|...|:|
Mouse   605 NVVANMNGIHSELNGGGENMALKDESPQVSSTSRSSSEADDEDADGESSGEPPGAPKQEEAIGNG 669

  Fly   649 SSGSVFRRQAETSDTLRTTYHIAWAVFQHLATRKRYRHETIEPQFICGENCRVSACQLARKILSN 713
            :.    :.:....:|...:|.         |.:......|.|    | ..|:..|..|....::.
Mouse   670 NP----KTEESNVNTPPPSYP---------AQQAEQTPNTCE----C-HVCKQEASGLPASAMTA 716

  Fly   714 QLSPLLTKYLLRCFQPLSFTREELR-----------STIPSL-------------MFFNRKLAPS 754
            ...|...::|    .|...|...|.           .|:|.|             .|.:.|..|
Mouse   717 GALPPGHQFL----SPEKPTHPALHLYPHIHGHVPLHTVPHLPRPLIHPTLYPAPPFTHSKALP- 776

  Fly   755 PAELQELRNQHYVYKTYWTFVLSIYANFFVKFNSSSTDFGHLELIKGDLRLRLNSVVGDKEDNRF 819
            ||.:|...|:...                  ||:|..|  |:          ..|..|:..|...
Mouse   777 PAPVQSHTNKPQA------------------FNASLQD--HI----------YPSCFGNTPDWNS 811

  Fly   820 EQFLAQVIGYSPFKVTDDFTLGDANIEKLQF------GVDQLMMLHDSQIIKRTKPDSTTGLSGA 878
            .:|::         :.:...:.|.|.....|      |.|.|     ..::..|:|::
Mouse   812 SKFIS---------LWESEMMNDKNWNPGTFLPDTISGNDIL-----GPVLSETRPEA------- 855

  Fly   879 KSKLGESNVPQSGGKNGEAGGNKKSKEK--MRKCCSDYADIGEPCKENHSKKRVKKECNHARFNE 941
                    :|........|..:.|.|:.  .:||..::.|......|......|....:.|..:.
Mouse   856 --------LPPPPSNEAPAVSDIKEKKNAAKKKCLYNFQDAFMEANEVAMANTVAMATSSATSSV 912

  Fly   942 --TRDRLRKKLSQI-VNERKTKST------------EETTPSKTKCS----KPEPVAVP---APA 984
              |...::...||. |:.|:..|.            ..:.|:..:.|    .|.|...|   :||
Mouse   913 SCTATTVQSSSSQFKVSSRRPPSIGDVFHGLNKEDHRHSAPAAPRNSPTGLAPLPALSPSALSPA 977

  Fly   985 AIP-------PKRP-----------------PSPFNPPKLPAVLAVAALDRICR----EEH---- 1017
            :.|       |..|                 |:|..||......:::|...:|.    |.|
Mouse   978 STPHLPNLAAPSFPKTATTAPGFVDTRKSFCPTPVAPPPSTTDGSISAPPSVCSDPDCEGHRCEN 1042

  Fly  1018 ------EDDSLLRLDSLCKSLQRHTDATDAS--------AAAAALAAFKHGSGFPA-----DYS- 1062
                  :||.....|.  .|...|:.:|..|        ........|.|| |.||     :|:
Mouse  1043 GVYDPQQDDGDESADE--DSCSEHSSSTSTSTNQKEGKYCDCCYCEFFGHG-GPPAAPTSRNYAE 1104

  Fly  1063 ------------KEDM---MQDFAEFLGTYTYTREQDQQRWINETLNFIEGKSQQPHTANPKKAA 1112
                        ||:.   |:..:|..|...:.|.:|..::||         |.:....:..:||
Mouse  1105 MREKLRLRLTKRKEEQPKKMEQISEREGVVDHRRVEDLLQFIN---------SSEAKPVSSSRAA 1160

  Fly  1113 KKAKQKMRK--------------------EEEKRIKELEDLRCQFLDIYFK-EFIDKYEMKTLTA 1156
            |:|:.|.||                    ||:|:.:|.||...:..:.:|| ||....|::.|.|
Mouse  1161 KRARHKQRKLEEKARLEAEARAREHLHHQEEQKQREEEEDEEEEDEEQHFKEEFQRLQELQKLRA 1225

  Fly  1157 AGGRKKEK--KRIGELETNIKNLQRAKAKVETVILELIATVKQTNSEFKFSYLPTKQQQLAKMAQ 1219
            |..:||::  |...:|:...:|.|.|...:             :|||         ......:.|
Mouse  1226 AKKKKKDRPSKDCSKLDMLARNFQAATESI-------------SNSE---------NIHNGSLEQ 1268

  Fly  1220 LEEILNGGPTTATAEPVRQEPPQQSAPQYPEFSSNASFYHPPGLGQQNTPVCFAPPQQSQHPPQL 1284
            .||     |.|::..|.|.....:..|            .|...|....||          .|:
Mouse  1269 TEE-----PETSSHSPSRHMNHSEPRP------------GPGANGDATDPV----------DPR- 1305

  Fly  1285 SRDVIAAMAASSITADPSKRIVTIRRVQLPHPGAEQQVTVVAKGSAPHEDKLLYTFVNGHMVASG 1349
                           ||||.:       ||.....:|          ||.......:..|.....
Mouse  1306 ---------------DPSKLL-------LPKEVNGKQ----------HEPLAFLLDMMHHHKEGN 1338

  Fly  1350 PIQPEEMAPRQATVPAPAPSVPEKSAKAKKKEAKRAAAAAAAEAAAAAEAAAAAAAEAAAEQKAK 1414
            ..|..:...:.:..||..|:.|.|:.:.:.|                        ..|..|.|.|
Mouse  1339 SKQKLKQTSKTSNEPARKPTEPPKTTEVQLK------------------------PRAQPELKPK 1379

  Fly  1415 L-------KNKKQAKKTAVAVATASSSTASSNSSKSQTPQSTRESSVCSVKPKTVPKKPTS--KP 1470
            :       :.|::.:|           |.|:|::|.|. ...:|..:.:|.|:  |..|:.  :.
Mouse  1380 VVDLALLTEQKREERK-----------TNSNNNNKKQL-SHIKEEKLSTVTPE--PPSPSQLLQN 1430

  Fly  1471 PKVVEVTPPPPVPEPEPEPPKRQKRLKSRLD----PGQLDNNPWKALHMQDSSEGEWE 1524
            .:::..:.|.|..:.:....|:..|..|.||    |..:|      |...|..|.|.|
Mouse  1431 GRLILASSPQPKGKNKKNKKKKGDRTSSSLDDVFLPKDID------LDSVDMDETERE 1482

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7518	NP_731761.3	None
Fam193a	NP_001230052.1	DUF3275	<941..>1021	CDD:288521	14/79 (18%)
		DUF4200	1104..>1179	CDD:290574	17/83 (20%)
		FAM193_C	1462..1515	CDD:292536	7/27 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850566
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2C6D2
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008017
OrthoInspector	1	1.000	-	-		oto95373
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR15109
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.930