Protein Alignment CG7518 and fam193a

DIOPT Version :9

• Sequence 1: NP_731761.3
• Gene: CG7518 / 41599
• FlyBaseID: FBgn0038108
• Length: 2464
• Species: Drosophila melanogaster
• Sequence 2: XP_004911320.1
• Gene: fam193a / 100495490
• XenbaseID: XB-GENE-995059
• Length: 1570
• Species: Xenopus tropicalis
• Alignment Length: 2011
• Identity: 364/2011 - (18%)
• Similarity: 596/2011 - (29%)
• Gaps: 752/2011 - (37%)

  Fly    50 GDVDATA------------SSSCVATASQLNPSPPPAGVQQAKPARSSSPPCQLLERLSFPDGNI 102
            |||.|.|            .|:.|..::.|.||||......:.|....:     |....|.||.
 Frog    24 GDVKAAALRGQHGATSGGSGSAGVGGSTGLIPSPPTGNCTPSTPGNEIA-----LNGTPFTDGP- 82

  Fly   103 INTLHTILALPPFD-------PYAPAPKAETVYKEVVSLMQWSQREDNAIELELSDKLLHECEHK 160
            :.|..:.:...||.       ||......         |:..|:|:|.          |.||..|
 Frog    83 LGTEFSQVPQAPFTFGLGQRAPYTTGDHC---------LLCRSERKDT----------LSECGTK 128

  Fly   161 GG-------DPNDETRSYL---------MAIEN--------MRLFSED------PKNPLRDAD-- 193
            ..       .|...::.:|         ..:||        ..|.|:|      |.|.:...:
 Frog   129 NSSKLALSTSPKSSSKLHLPLWVCSDCRRTVENEEIHTPQDQSLASQDFLLHMPPGNSVSKQESL 193

  Fly   194 --------GQLRAITLYFQN-----LAFIFVKHRKEEFFTFCSCKECLEYRETIMAIMMDQFKAA 245
                    .|....|:...|     :|              |||:.|.|.||
 Frog   194 GGGRMLVGAQTVPSTVALNNSTPPDIA--------------CSCEACNERRE------------- 231

  Fly   246 HMVVMLLDVLIKAYSPMLKN---DAAYNKFEKLLECNKEIYWITSGYLYDKNAEYL--------D 299
                  :....:..|..|:|   |..|     ::.|   ||......|.|...:.|        |
 Frog   232 ------ISAETERESQQLQNYWSDVRY-----MIRC---IYRQAGTPLADDQDQSLVPDKDGMKD 282

  Fly   300 FIDDTAISDNMILVLFSAILMANNPMLLLQIL-----AYNVECIVKAFSEGMIEIAQNIQENEKI 359
            .:|.               |...:|..|.|.|     .|.:|..|:......|....|.......
 Frog   283 LVDR---------------LCERDPYQLYQRLEQQAREYVLEMKVRLLKHLSIGFKVNSTIQGPP 332

  Fly   360 SAERMLTYILDGYSDLNCISQKISLSLFAFENDFLRKFRLSWVLLCQRLFQQHVFT-PLGDTMLA 423
            .|.:.::.:|:.||.|...:..|...|...||:.|:||:::|.|..:.||:..||: ||....|.
 Frog   333 QAHQFISLLLEEYSALCQAACTIGTFLVTLENEHLKKFQVTWELHNKHLFENLVFSEPLLQNSLP 397

  Fly   424 CILSLKEVAPSAQT-------TALIKRYMLFDEHMHSIERRWTDIWIELNKFNLSPTEHERRMGL 481
            .::|...:..::..       :.|::||...::.|:.:...|              .|.::|
 Frog   398 ALVSQLRLGTASHDSYSEDMYSTLLQRYHQLEQEMNQVSEEW--------------LECQKR--- 445

  Fly   482 LDVYNIFDKVVLDATSFSLPDISDDEFIDFQRIVDRQLAWKNIMAFTKLKWPDGFYDPPNKLVHE 546
            :|.| :.:::.|......|.:  |.||...:|.::.||..|..:.     ..:.|.|....::..
 Frog   446 IDNY-VDEQMALKTKQRMLKE--DWEFFKQRRFIEEQLNNKKTVT-----GENNFTDKMRHMLST 502

  Fly   547 DL----CKKCNSLLEHHNENCKCITCSIAGTPLRPRQAGHCAKCTTLGIVEKDPKLMKSKILSTC 607
            .:    |..||     :...|.|..||::          |...|               .|:.|.
 Frog   503 RMCMSDCPNCN-----YRRRCTCDDCSLS----------HILTC---------------GIMDTP 537

  Fly   608 TSDEAKHNAAIAATTSSSTSTAQQQRRTSD-LPEDESPT-GSGSSGSVFRRQAETSDTLRTTYHI 670
            .:|:...|           ....|...|.| |.|...|: .|.||||
 Frog   538 LTDDIHLN-----------QLPLQVESTPDYLSEMHPPSMSSASSGS------------------ 573

  Fly   671 AWAVFQHLATRKRYRHETIEPQFICGENCRVSACQLARKILSNQLSPLLTKYLLRCFQPLSFTRE 735
                                     |.:..::..|..|.||::
 Frog   574 -------------------------GSSSPITIQQHPRLILAD---------------------- 591

  Fly   736 ELRSTIPSLMFFNRKLAPSPAELQELRNQHYVYKTYWTFVLSIYANFFVKFNSSSTDFGHLELIK 800
                                                               |.|:..||
 Frog   592 ---------------------------------------------------NGSAPTFG------ 599

  Fly   801 GDLRLRLNSVVGDKEDNRFEQFLAQVIGYSPF--KVTDDFTLG---DANI--------EKLQFGV 852
                       .|.||.            :|.  |..|.:.|.   ||::        .:|..|.
 Frog   600 -----------SDDEDG------------APLSAKYADIYPLNNYDDADVVANMNGIHSELNGGG 641

  Fly   853 DQLMMLHDSQIIKRTKPDSTTGLSGAKSKLGESNVPQSGGKNGEAGGNKKSKEKMRKCCSDYADI 917
            :.:.:..:|.::..|...|                  |...:.||.|         :.|.:.:::
 Frog   642 ENMALKDESPVVSSTSSSS------------------SEADDEEADG---------ESCGEQSEV 679

  Fly   918 GEPCKENHSKKRVKKECNHARFNETRDRLRKKLSQIVNERKTKSTEETTPSKTKCS----KPEPV 978
              |.::....||..               ||:.::|.:...:..:.:..|....|.    |.|..
 Frog   680 --PKEDLQIGKRSP---------------RKEGTKIESPPPSYLSPQVEPVPNSCECHVCKQEAS 727

  Fly   979 AVPAPAAIPPKRPP--SPFNPPKLPAVLAVAALDRICREEHEDDSLLRLDSLCKSLQRHTDATDA 1041
            .: :|:|:.|.|.|  ..|..|:.||..|:.....|    |....|..:..|.:.|...|
 Frog   728 GL-SPSALVPGRLPVGHQFINPEKPAHPALHLYPHI----HGHLPLHTIPHLPRPLIHPT----- 782

  Fly  1042 SAAAAALAAFKHGSGFPA-----DYSKEDM----MQDF---AEFLGTYTYTREQDQQRWINETLN 1094
               ..|.:.|.|....|.     ..||..:    :||.   :.|..:..:.|.:....|.:|.:|
 Frog   783 ---LYAASPFAHNKALPPTTVPNHTSKHQVFNASLQDHIYPSCFGNSPEWNRSKFLSLWGSEMMN 844

  Fly  1095 FIEGKSQQPHTANPKKAA-----KKAKQKMRKE---------------EEKRIKELEDLRCQFLD 1139
               .|:..|.|..|...|     ..|..::|.|               :||:....:.....|.|
 Frog   845 ---EKNWNPATFLPDPLAGGEILGPALPEIRPEALPISSSDSAPVHDIKEKKNSAKKKCLYNFQD 906

  Fly  1140 IYFKEFIDKYEMKTLTAAGG-----------------RKKEKKRIGELETNIKNLQRAKAKVETV 1187
            .:.:.  :|..|.|.:|...                 ..|....|||:..|||...|..:
 Frog   907 AFIES--NKVVMATSSATSSVSCTATTVQSSSNQFKVSSKRPSSIGEVFHNIKEDHRHPS----- 964

  Fly  1188 ILELIATVKQTNSEFKFSYLPTKQQQLAKMAQLEEILN----GGPTTATAEPVRQEP-----PQQ 1243
                 ......||....|.|||....:...|....|.:    ..|.||...|...:|     |..
 Frog   965 -----TPAAPRNSPTSLSSLPTISPAVHSSAPSSHIQSIAAPSFPKTAATAPGFVDPHLGFCPST 1024

  Fly  1244 SAPQYPEFSSNASFYHPPGLGQQNTPVCFAPP------------QQSQHPPQLSRDVIAAMAASS 1296
            :||  |..:::.:...||.       ||..|.            ...|:..:.|:|..:....||
 Frog  1025 AAP--PTSTTDGNLSAPPS-------VCSDPDCEGHRCENNGAYDHQQYDGEESQDEDSCSEHSS 1080

  Fly  1297 IT---------------------------ADPSKRIVTIR---RVQLPHPGAEQ-----QVTVVA 1326
            .|                           |..|:....:|   |::|.....||     |:....
 Frog  1081 STSTSTNQKEGKYCDCCYCEFFGHGGPPSAPTSRNYAEMREKLRLRLTKRKEEQPKKPDQLPERD 1145

  Fly  1327 KGSAPHEDKL--LYTFVNGHMVASGPIQPEEMAPRQATVPAPAPSVPEKSAKAKKKEAKRAAAAA 1389
            .|......|:  |..|:|..  .|.|:.....|.|                 |:.|:.|....:.
 Frog  1146 TGGVVDHRKVDDLVQFINSS--ESKPVSSSRAAKR-----------------ARHKQRKEYGTSP 1191

  Fly  1390 AAE-----------------AAAAAEAAAAAAAEAAAEQKAKLKNKKQAKKTAVAVATASSSTAS 1437
            |..                 ::.|.|....|.||...|:..|.:.:::|::.|
 Frog  1192 AINKIVSHVLGSERSMQGSCSSTAEERTDKAEAEPDKERLGKQQLEEKARQEA------------ 1244

  Fly  1438 SNSSKSQTPQSTRESSVCSVKPKTVPKKPTSKPPKVVEVTPPPPVPEPEPEPPKRQKRLKSRLDP 1502
                      ..||.....:..:...::...:..:.::       ...|.:..|::|:.:|..|.
 Frog  1245 ----------EVREQEELQLLEEQRQREEEERLKQELQ-------RHQECQALKKKKKERSSKDS 1292

  Fly  1503 GQLDNNPWKALHMQDSSEGEWETGSESDEGVP--TPAQPPIRQQPKLPAAPAPKPVAPSVVTKAK 1565
            .:||    :..|....::   |..:.:.|.||  |..||.|::     ..|.|...:|:..|:..
 Frog  1293 HKLD----RLAHHPLCNK---EPIAITSELVPNGTVEQPEIKE-----TLPVPLLGSPAHRTEPS 1345

  Fly  1566 PAPAAVAAPAKKVKQQEAPAHQKQPAAKTQAQPKSKSTFASVGKSNPPQQQQQQYQQEKVPPTKS 1630
            |.|.|:..|......::..:|       |..:.|:|                 |::|..:....:
 Frog  1346 PLPEALNKPPHHTNGRDCTSH-------THREAKAK-----------------QHEQLSLLLDLA 1386

  Fly  1631 QQQRPAESSRKQKQAPGNLESNRSAPNQRCEHLQTQQAPRSGRVNGRTKPTPGGQQQPVQQHSNA 1695
            ..:   |.|.||||           |..:...|..:|..:|....      |...|..|:.||.|
 Frog  1387 HHK---EYSVKQKQ-----------PKLQIPKLSPEQVKKSEACK------PPDAQAKVRNHSEA 1431

  Fly  1696 HAAESIAPP----KKSQRGKRGHRQKQEDLSGIPHNMGYFNPNEIAIPPQSGSYASTL-AQQLQH 1755
            ......|||    |:.::...|:.:||              ||.:.....||:....: ::|.|:
 Frog  1432 KVRAVEAPPVVEQKREEKKSNGNNKKQ--------------PNHVKEEKTSGAGDPFMHSEQPQN 1482

  Fly  1756 LRI-----SQPGGSS--NSKEASQSPNCSIMDQLNRGVQVEHLSLPPGITLTKVDPAKSEQ 1809
            .::     .||.|.:  |.|:.....|.||.|          :.||..|.|..|:..::|:
 Frog  1483 NKLLKAESPQPKGKNKKNKKKKGDKINSSIDD----------VFLPKDIDLDSVEMDETER 1533

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG7518	NP_731761.3	None
fam193a	XP_004911320.1	CFTR_protein	<346..>445	CDD:273530	25/112 (22%)
		Herpes_BLLF1	<775..1044	CDD:282904	59/300 (20%)
		FAM193_C	1514..1569	CDD:374220	7/30 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008017
OrthoInspector	1	1.000	-	-		oto105551
Panther	1	1.100	-	-	O	PTHR15109
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.100