Protein Alignment CG31342 and Apba1

DIOPT Version :10

• Sequence 1: NP_001097763.1
• Gene: CG31342 / 41592
• FlyBaseID: FBgn0051342
• Length: 994
• Species: Drosophila melanogaster
• Sequence 2: NP_796008.2
• Gene: Apba1 / 319924
• MGIID: 1860297
• Length: 842
• Species: Mus musculus
• Alignment Length: 945
• Identity: 180/945 - (19%)
• Similarity: 305/945 - (32%)
• Gaps: 300/945 - (31%)

  Fly   189 PLPPPPPVPAALVPGVERVVAPSHQAPPAPPPEPPTSPVPTTPAPPAPAPAAMSNT-LTQHLLNM 252
            |.|.||| ||...|       ..|:..|||||.||.............|.:|.:.: ...|....
Mouse    40 PSPSPPP-PAGHEP-------EDHRGHPAPPPPPPPQEEEEEERGECLARSASTESGFHNHTDTA 96

  Fly   253 LSDPISTYSEQI-SESVESASGQEDVAVAEEPPAEQPT-TSDAD--------------------- 294
            ..|.::...:.. :|..:.|..:...||...|.||:.| .::|:
Mouse    97 EGDVLAAARDGYEAERAQDADDESAYAVQYRPEAEEYTEQAEAEHVEAAQRRALPNHLHFHSLEH 161

  Fly   295 ---LNLS---------------DDEYLSPL---------------------LRKACMLTEN---- 316
               :|.:               |:.|..|.                     .|....|.|.
Mouse   162 EEAMNAAYSGYVYTHRLFHRAEDEPYAEPYADYGGLQEHVYEEIGDAPELEARDGLRLYERERDE 226

  Fly   317 ---------GARV----------------DVVVVTGQRV-SADQVLNLEHILQCERLIPRPQTSR 355
                     |||:                :.......|: |.:|..:::.|:        .:..:
Mouse   227 AAAYRQEALGARLHHYDERSDGESDSPEKEAEFAPYPRMDSYEQEEDIDQIV--------AEVKQ 283

  Fly   356 SMSAGAADKSKRPQRKPLQSQSSSAAPTNSADSQDNITIIQVSNTANSGQEHPPELPPKNTTTAE 420
            |||:.:.||:  .:..|...|....|||......|:..:     .|.:||:......|..:...:
Mouse   284 SMSSQSLDKA--AEDMPEAEQDLERAPTPGGGHPDSPGL-----PAPAGQQQRVVGTPGGSEVGQ 341

  Fly   421 VFRFPEVKSKPQTNAKQQPIQTHHEYKSNVQIIPSNASSSTSTIQVLGKQSSSSNPYTTPVKQSS 485
            .:      ||.:.:|....|:...|....|:         |.||:         :|||....:..
Mouse   342 RY------SKEKRDAISLAIKDIKEAIEEVK---------TRTIR---------SPYTPDEPKEP 382

  Fly   486 SNGSSSQVSGTTKV--KVLGDGDATTKVAVYGTCYPAAGGSAPSSSAASSSV-----NPAKPQTP 543
            .......:|.|...  :...|||:           |:.|.|:| ..|.|||:     :|.:..|.
Mouse   383 IWVMRQDISPTRDCDDQRPVDGDS-----------PSPGSSSP-LGAESSSIPLHPGDPTEASTN 435

  Fly   544 RLSKKIILSANTSGITNISVNTEQGSDSIISGNIHYEKVFLSSSIPITSRSSPTR---------- 598
            :.|:|.:.|..    |.:.|......:.:|.| |.:...:|.|: .:.|..:|::
Mouse   436 KESRKSLASFP----TYVEVPGPCDPEDLIDG-IIFAANYLGST-QLLSDKTPSKNVRMMQAQEA 494

  Fly   599 VANTNTTQPVTNGSPALPRRRLASPATAQPVTPNAAGRATPQLTRGLTELVISSRPSRRDFHYLK 663
            |:...|.|.:...      |:.|....:||:|.              .:|.||::       .:|
Mouse   495 VSRIKTAQKLAKS------RKKAPEGESQPMTE--------------VDLFISTQ-------RIK 532

  Fly   664 LLNT---------PLKT--------------KTSHKSTSAANNNIEQSTPSSSNSTQVTPTQRNN 705
            :||.         ||:|              .......|.:..|:|.|.||.
Mouse   533 VLNADTQEPMMDHPLRTISYIADIGNIVVLMARRRMPRSNSQENVEASHPSQ------------- 584

  Fly   706 TSIVTGDSQEQRR---RSSSTSDAQAPLQRVPQPATQRNANNNEFTPSRNGAFRMQPPPQGTPPS 767
                  |.:.|.:   ....:.|||...|.:.|..   :....||..: ||
Mouse   585 ------DGKRQYKMICHVFESEDAQLIAQSIGQAF---SVAYQEFLRA-NG-------------- 625

  Fly   768 STNPAQQSPNKRLTLREQQVMQLRREIMHPG------GVRLNLRRKDCVGSI----AWVEAFGGV 822
             .||...|..:...|...|.| ...:::|..      .|.:..::.:.:|.:    .|......|
Mouse   626 -INPEDLSQKEYSDLLNTQDM-YNDDLIHFSKSENCKDVFIEKQKGEILGVVIVESGWGSILPTV 688

  Fly   823 WIAGWKQKEHPVLYNALHIGDQLLSIAGVS-----ISSAAEANKIIRNTNTLFVEVLLRRIPFGR 882
            .||.............|:||||::||.|.|     :|:.....|.::|.:.:.:.::  |.|...
Mouse   689 IIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLPLSTCQSIIKGLKNQSRVKLNIV--RCPPVT 751

  Fly   883 AYAIRRDREGQCLGL-IRDGNTSTIVDVVPNSLAARHGLPPKTQSCDGNSLTFWMLTEINGRSLN 946
            ...|||......||. :::|   .|..::...:|.|.|:....:           :.||||:|:.
Mouse   752 TVLIRRPDLRYQLGFSVQNG---IICSLMRGGIAERGGVRVGHR-----------IIEINGQSVV 802

  Fly   947 LFFKDFEIRDRLNSVGRDISILVQPSDLITKLKKQ 981
            ....:..:....|:|| :|.:...|:.:...|..|
Mouse   803 ATPHEKIVHILSNAVG-EIHMKTMPAAMYRLLTAQ 836

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31342	NP_001097763.1	PHA03247	<589..785	CDD:223021	40/231 (17%)
		PDZ_canonical	<838..866	CDD:483948	11/32 (34%)
		PDZ_canonical	879..969	CDD:483948	20/90 (22%)
Apba1	NP_796008.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..121		22/88 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	238..349		22/131 (17%)
		Mint1_CID	348..393	CDD:439308	11/62 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	366..439		21/102 (21%)
		PTB_X11	457..628	CDD:269919	41/237 (17%)
		Autoinhibitory helix linker. /evidence=ECO:0000250	631..648		4/17 (24%)
		PDZ1_APBA1_3-like	660..745	CDD:467203	18/84 (21%)
		PDZ2_APBA1_3-like	749..826	CDD:467255	19/91 (21%)