DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7381 and SCARF2

DIOPT Version :9

Sequence 1:	NP_650242.1	Gene:	CG7381 / 41589	FlyBaseID:	FBgn0038098	Length:	712	Species:	Drosophila melanogaster
Sequence 2:	NP_699165.3	Gene:	SCARF2 / 91179	HGNCID:	19869	Length:	871	Species:	Homo sapiens

Alignment Length:	448	Identity:	99/448 - (22%)
Similarity:	138/448 - (30%)	Gaps:	155/448 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   368 KKYGSSCTDNGKTCSGLPHSICSKN-------ICLCRQGYYARN--GKCFAEL------------ 411
            ::.|..|  ....|.|  :|.||:|       .|.||.||:..|  .||..:.
Human    69 RQQGDEC--GIAVCEG--NSTCSENEVCVRPGECRCRHGYFGANCDTKCPRQFWGPDCKELCSCH 129

  Fly   412 --GEIAESTDECEYEF----DQLTKTCNCQKNYFYERDLRNCR-KPIQYHLSCTS------NSQC 463
              |:..:.|.:|....    .:....|.||....:.|. ..|| :|..:...|.|      .|:|
Human   130 PHGQCEDVTGQCTCHARRWGARCEHACQCQHGTCHPRS-GACRCEPGWWGAQCASACYCSATSRC 193

  Fly   464 SP-FGASYCHP-----EIPRRCTCEEYALYDAIKQLCEYKRG--------LGAECESNDGC---- 510
            .| .||..||.     ....:|.|.        ...||.:.|        .||.|:....|
Human   194 DPQTGACLCHAGWWGRSCNNQCACN--------SSPCEQQSGRCQCRERTFGARCDRYCQCFRGR 250

  Fly   511 --PVDHSVCSNRVCVCADNYFEK--DDQC---MRGIGA-----------DCSVED----DCIP-- 551
              |||.:      |.|...|..|  .:.|   ..|:|.           .|:|.:    .|.|
Human   251 CHPVDGT------CACEPGYRGKYCREPCPAGFYGLGCRRRCGQCKGQQPCTVAEGRCLTCEPGW 309

  Fly   552 ENTECQEKDE-----EDQSRTC-QCRKGYV--HFKDECLK-EAEELEDEC-------VEDEQCKP 600
            ..|:|.:...     |..|..| .||.|:.  |...:|.: .|..:.|.|       ...|.|..
Human   310 NGTKCDQPCATGFYGEGCSHRCPPCRDGHACNHVTGKCTRCNAGWIGDRCETKCSNGTYGEDCAF 374

  Fly   601 LLASCNS------EGKCGCNDEQHAK--NGVCETKRELGESCTKATECYVEK-DPENVEC----- 651
            :.|.|.|      .|:|.|:...|..  |..|..... |..|.:|..|:.:. ||....|
Human   375 VCADCGSGHCDFQSGRCLCSPGVHGPHCNVTCPPGLH-GADCAQACSCHEDTCDPVTGACHLETN 438

  Fly   652 -RNSV---------------------CQCKLGYSANANQNQCIRVMPNKKNSSGRPSA 687
             |..|                     |.|:       .::...|..|.::.|.||..|
Human   439 QRKGVMGAGALLVLLVCLLLSLLGCCCACR-------GKDPTRRPRPRRELSLGRKKA 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7381	NP_650242.1	EB	68..112	CDD:279949
		EB	101..155	CDD:279949
		EB	570..624	CDD:279949	18/71 (25%)
		EB	613..665	CDD:279949	15/81 (19%)
SCARF2	NP_699165.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		PHA03247	<534..871	CDD:223021
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	570..871
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900