DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7381 and MEGF11

DIOPT Version :9

Sequence 1:	NP_650242.1	Gene:	CG7381 / 41589	FlyBaseID:	FBgn0038098	Length:	712	Species:	Drosophila melanogaster
Sequence 2:	NP_001371957.1	Gene:	MEGF11 / 84465	HGNCID:	29635	Length:	1140	Species:	Homo sapiens

Alignment Length:	798	Identity:	157/798 - (19%)
Similarity:	227/798 - (28%)	Gaps:	308/798 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 CAVLSPQGDGGVLAVFWPCETEADCTADGTSCDFASGQCECSTFDTVLAENFTQCLATSLIGEKC 79
            ||...|.|..|     ..|..:..| ..|..||..:|||.|:               ...:|::|
Human   258 CAQPCPPGTFG-----QNCSQDCPC-HHGGQCDHVTGQCHCT---------------AGYMGDRC 301

  Fly    80 DDSVQCNLMPTGASCKAGVCDCADGQNYLRGKCRPLNGLGESCETDLDCYFGYDRASVSCQQNVC 144
            .:  :|.....|..|... |||.:|     |:|.|..|   :||    |..||  ....||:.:|
Human   302 QE--ECPFGSFGFQCSQH-CDCHNG-----GQCSPTTG---ACE----CEPGY--KGPRCQERLC 349

  Fly   145 -------------------------------------------GCANGYYNRYGNICRRKSMEEN 166
                                                       .|..||   ||:.|:...
Human   350 PEGLHGPGCTLPCPCDADNTISCHPVTGACTCQPGWSGHHCNESCPVGY---YGDGCQLPC---- 407

  Fly   167 DACVVNADCDELGAGVEC----VGLVCTYVDEITTTPGGETEETETTNPG---SPEDDDSTTAEA 224
             .|...|||..:..|..|    :|.||. |.....|.|.......:.|.|   ||.|...|..|.
Human   408 -TCQNGADCHSITGGCTCAPGFMGEVCA-VSCAAGTYGPNCSSICSCNNGGTCSPVDGSCTCKEG 470

  Fly   225 ITETAD-----PEQETAFSSRRQLTKAFVHAPPPTHSDAAAQVSFAQLTNGDTEPLISPRSHEIA 284
             .:..|     |......:.....|.|...|..|.....:....:.    |||..|..|
Human   471 -WQGLDCTLPCPSGTWGLNCNESCTCANGAACSPIDGSCSCTPGWL----GDTCELPCP------ 524

  Fly   285 VQTSIEKYELREVGRSVRNAATATTTTTATASTSTSSRRNSSRNQRHAHGQRRRLPALFRFDDED 349
                                       ..|...:.|...:.|    ||.|          .|...
Human   525 ---------------------------DGTFGLNCSEHCDCS----HADG----------CDPVT 548

  Fly   350 IKTYSTLG--SSRDDDDADEKKYGSSCT-----DNGKTCS----------GLPHSICSKNICLCR 397
            .......|  ..|.|......::|.:|:     :||.:||          |....:|.:   :|.
Human   549 GHCCCLAGWTGIRCDSTCPPGRWGPNCSVSCSCENGGSCSPEDGSCECAPGFRGPLCQR---ICP 610

  Fly   398 QGYYARNGKCFAELGEIAESTDECEYEFDQLTKTCN-------------CQKNYFYERDLRNCRK 449
            .|:|...  |.........|:..|.:    ::..|.             |...||.:...:.|
Human   611 PGFYGHG--CAQPCPLCVHSSRPCHH----ISGICECLPGFSGALCNQVCAGGYFGQDCAQLC-- 667

  Fly   450 PIQYHLSCTSNSQCSPFGASYCHPEIPRRCTCEEYALYDAIKQLCEYKRGLGAECESNDGCPVDH 514
                  ||.:|..|||...|         |.|              :...:|.:|  :..||...
Human   668 ------SCANNGTCSPIDGS---------CQC--------------FPGWIGKDC--SQACPPGF 701

  Fly   515 --SVCSNRVCVCADNYFEKDDQCMRGIGADCSVED---DCIPENTE--CQEKDE-----EDQSRT 567
              ..|.: .|.|.:             ||.||.||   .|.|..|.  |.::..     :|..|.
Human   702 WGPACFH-ACSCHN-------------GASCSAEDGACHCTPGWTGLFCTQRCPAAFFGKDCGRV 752

  Fly   568 CQCRKGYVHFKDECLKEAEELEDECVEDEQCKPLLASCNS-EGKCGCN---DEQHAKNGVCETK- 627
            |||:.|                             |||:. .|||.|.   ..||     ||.:
Human   753 CQCQNG-----------------------------ASCDHISGKCTCRTGFTGQH-----CEQRC 783

  Fly   628 --RELGESCTKATECYVEKDPENVECRNSVCQCKLGYSA-NANQ--------NQCIRVMP---NK 678
              ...|..|.:..||......::|   ...|.|..|:.. ..:|        |...::.|   .:
Human   784 APGTFGYGCQQLCECMNNSTCDHV---TGTCYCSPGFKGIRCDQAALMMEELNPYTKISPALGAE 845

  Fly   679 KNSSGRPSALKIITFMLI 696
            ::|.|..:.:.::.|:::
Human   846 RHSVGAVTGIMLLLFLIV 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7381	NP_650242.1	EB	68..112	CDD:279949	10/43 (23%)
		EB	101..155	CDD:279949	17/96 (18%)
		EB	570..624	CDD:279949	11/57 (19%)
		EB	613..665	CDD:279949	13/58 (22%)
MEGF11	NP_001371957.1	EMI	26..93	CDD:400092
		EGF_CA	275..320	CDD:419698	14/63 (22%)
		EGF_CA	362..409	CDD:419698	6/54 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D561378at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910