DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7381 and megf10

DIOPT Version :9

Sequence 1:	NP_650242.1	Gene:	CG7381 / 41589	FlyBaseID:	FBgn0038098	Length:	712	Species:	Drosophila melanogaster
Sequence 2:	NP_001072726.1	Gene:	megf10 / 780183	XenbaseID:	XB-GENE-491974	Length:	1114	Species:	Xenopus tropicalis

Alignment Length:	783	Identity:	148/783 - (18%)
Similarity:	207/783 - (26%)	Gaps:	369/783 - (47%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 WFLTLGVLCCAVLSPQGDGGVLAVFWPCETEADCTADGTSCDFASGQCECSTFDTVLAENFTQCL 70
            |..|:    |....|:|..|     ..|..|..|...|| ||.|:|||.||
Frog   258 WMGTV----CGQPCPEGRYG-----RNCSQECQCHNGGT-CDSATGQCYCS-------------- 298

  Fly    71 ATSLIGEKCDDSVQCNLMPTGASCKAGVCDCADGQNYLRGKCRPLNG--------LGESCETDL- 126
             ....||:|.:  :|.:...|..| |..|.|.:|     |||..::|        .||.|||.|
Frog   299 -PGYNGERCQE--ECPVGLYGVKC-AQTCQCLNG-----GKCYHISGACLCEPGYTGERCETPLC 354

  Fly   127 -------------DCYFGYDRASVSC--QQNVCGCANG----YYNR------YGNICRRKSMEEN 166
                         .|:..|.:   ||  ....|.|..|    |.|.      ||..|     ::.
Frog   355 SEGTYGMKCDKKCPCHLQYTQ---SCHPMSGECACKPGRSGLYCNETCSLGFYGEFC-----QQI 411

  Fly   167 DACVVNADCDELGAGVECVGLVCTYVDEITTTPGGETEETETTNPGSPEDDDSTTAEAITETADP 231
            .:|...||||.:..  :|   :|.                    ||....|.||.
Frog   412 CSCQNGADCDSVTG--KC---ICA--------------------PGFTGVDCSTA---------- 441

  Fly   232 EQETAFSSRRQLTKAFVHAPPPTHSDAAAQVSFAQLTNGDTEPLISPRSHEIAVQTSIEKYELRE 296
                              .||.|:.     |:.:.|.|.....:.||
Frog   442 ------------------CPPGTYG-----VNCSSLCNCKNNAVCSP------------------ 465

  Fly   297 VGRSVRNAATATTTTTATASTSTSSRRNSSRNQRHAHGQRRRLPALFRFDDEDIKTYSTLGSSRD 361

Frog   466 ----------------------------------------------------------------- 465

  Fly   362 DDDADEKKYGSSCTDNGKTCSGLPHSI-CSKN------------ICLCRQGYYARNGKCFAELGE 413
                         .|...||....|.: ||.|            .|.|..|     |.|
Frog   466 -------------VDGSCTCKAGWHGVDCSINCPRGSWGLGCNLTCQCLNG-----GAC------ 506

  Fly   414 IAESTDECEYEFDQLTKTCNCQKNYFYERDLRNCRKPIQ---YHLSCTSNSQCSPFGASYCHPEI 475
                        :.|..||.|...:   |.|: |..|.|   |.::|.....||  .|..|||..
Frog   507 ------------NPLDGTCTCAPGW---RGLK-CELPCQDGTYGMNCIERCDCS--HADGCHPAT 553

  Fly   476 PR-RCTCEEYALY-DAI----------KQLCEYKRGLGAECESNDGCPVDHSVCSNRVCVCADNY 528
            .. ||......:: |::          ...|:.|.  ||.|..:||           :|.||..|
Frog   554 GYCRCLAGWAGMHCDSVCPGGHWGPNCSLSCDCKN--GASCSPDDG-----------ICECAPGY 605

  Fly   529 FEKDDQCMR----GI-GADCSVE-DDCIPENTECQEKDEEDQSRTCQCRKGYV-----------H 576
              :...|.|    |. |..||.. ..|:..|..|.....:     |.|..|::           .
Frog   606 --RGTTCQRICSPGFYGHRCSQACPQCVHSNGPCHHVTGQ-----CDCLAGFMGSLCNEVCPSGR 663

  Fly   577 FKDECLKEAEELEDECVEDEQCKPLLASC----------------------NSEGKCGCNDEQH- 618
            :...|....     .|..:..|.|:..:|                      |....|.|::..:
Frog   664 YGKNCAGVC-----ACTNNGTCNPIDGTCQCYPGWIGNDCSQACPPGHWGPNCIHTCNCHNGAYC 723

  Fly   619 -AKNGVCE----------TKR----ELGESCTKATECYVEKDPENVECRNSVCQCKLGYSANANQ 668
             |.:|.|:          |:|    ..|:.||...:|....|.:::   ...|.|:.|:.....:
Frog   724 SAYDGECKCSPGWTGLYCTQRCPLGYYGKECTLVCQCQNGADCDHI---TGQCTCRTGFMGKFCE 785

  Fly   669 NQC 671
            .:|
Frog   786 QKC 788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7381	NP_650242.1	EB	68..112	CDD:279949	11/43 (26%)
		EB	101..155	CDD:279949	21/87 (24%)
		EB	570..624	CDD:279949	12/88 (14%)
		EB	613..665	CDD:279949	14/67 (21%)
megf10	NP_001072726.1	EMI	31..98	CDD:369419
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D561378at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010