DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7381 and Megf6

DIOPT Version :9

Sequence 1:	NP_650242.1	Gene:	CG7381 / 41589	FlyBaseID:	FBgn0038098	Length:	712	Species:	Drosophila melanogaster
Sequence 2:	NP_075244.1	Gene:	Megf6 / 65049	RGDID:	621188	Length:	1574	Species:	Rattus norvegicus

Alignment Length:	875	Identity:	165/875 - (18%)
Similarity:	232/875 - (26%)	Gaps:	400/875 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 TLGVLCCAVLSPQGDGGVLAVFWPC------------ETEADCTAD------------------- 42
            |.||.|        .|....|..||            :|..||.||
  Rat   739 TFGVNC--------SGSCSCVGAPCHRVTGECLCPPGKTGEDCGADCPEGRWGLGCQEICPACEH 795

  Fly    43 GTSCDFASGQCECSTFDTVLAENFTQCLATSLIGEKCDDSV------------------------ 83
            |.||:..:|.|.|               ....:|.:|.|:.
  Rat   796 GASCNPETGTCLC---------------LPGFVGSRCQDTCSAGWYGTGCQIRCACANDGHCDPT 845

  Fly    84 --QCNLMP--TGASCKAGV------------CDCADGQNYLRGKCRPLNGLGESCETDLDCYFGY 132
              :|:..|  ||.||:...            |:|:.|    .|.|..::||   |.    |..||
  Rat   846 TGRCSCAPGWTGLSCQRACDSGHWGPDCIHPCNCSAG----HGNCDAVSGL---CL----CEAGY 899

  Fly   133 DRASVSCQQNVCGCANGYYNRYGNICRRKSMEENDACVVNADCDELGAGVECV----GLVCTYVD 193
            :  ...|:|:   |..||   ||..|.:|.     .|...|.||.:.....|.    |..|.:
  Rat   900 E--GPRCEQS---CRQGY---YGPSCEQKC-----RCEHGAACDHVSGACTCPAGWRGSFCEH-- 949

  Fly   194 EITTTPGG----ETEETETTNPGSPEDDDSTTAEAITETADPEQETAFSSRRQLTKAFVHAPPPT 254
               ..|.|    :.:.....:.|:|  .|:.|...|....           |...:.....||.|
  Rat   950 ---ACPAGFFGLDCDSACNCSAGAP--CDAVTGSCICPAG-----------RWGPRCAQSCPPLT 998

  Fly   255 HSDAAAQVSFAQLTNGDTEPLISPRSHEIAVQTSIEKYELREVGRSVRNAATATTTTTATASTST 319
            .....:|:.                                    :..|.|:..:.|
  Rat   999 FGLNCSQIC------------------------------------TCFNGASCDSVT-------- 1019

  Fly   320 SSRRNSSRNQRHAHGQRRRLPALFRFDDEDIKTYSTLGSSRDDDDADEKKYGSSCTDNGKTC-SG 383
                          ||....|...                                  |.|| ..
  Rat  1020 --------------GQCHCAPGWM----------------------------------GPTCLQA 1036

  Fly   384 LPHSICSKNI---CLCRQGYYARNGKCFAELGE---------IAESTDECEYE------------ 424
            .|..:..||.   ||||.|     |:|...||:         :|     ||.|
  Rat  1037 CPPGLYGKNCQHSCLCRNG-----GRCDPILGQCTCPEGWTGLA-----CENECLPGHYAAGCQL 1091

  Fly   425 ---------FDQLTKTCNCQKNYFYERDLRNCRK-----PIQYHLSCTSNSQCSPF-GASYCHP- 473
                     .|:||..|.|...:..::...:|..     ..:.|.:|...:.|... ||.:|.|
  Rat  1092 NCSCLHGGICDRLTGHCLCPAGWTGDKCQSSCVSGTFGVHCEEHCACRKGASCHHVTGACFCPPG 1156

  Fly   474 --------EIPR---------RCTCEEYALYDAIKQLCEYKRG--------------LGAECESN 507
                    ..||         ||.|...|....:...|....|              .|.:||..
  Rat  1157 WRGPHCEQACPRGWFGEACAQRCLCPTNASCHHVTGECRCPPGFTGLSCEQACQPGTFGKDCEHL 1221

  Fly   508 DGCPVDHSVC--SNRVCVCADNYF-----------------EKDDQCMRG--------------- 538
            ..||.:...|  ::.||.||..|.                 |...:|:.|
  Rat  1222 CQCPGETWACDPASGVCTCAAGYHGTGCLQRCPSGRYGPGCEHICKCLNGGTCDPATGACYCPAG 1286

  Fly   539 -IGADCSVEDDCIPE---NTECQEKDEEDQSRTCQCRKGYV--HFKDECL----KEAEELEDECV 593
             :|||||:   ..|:   ...|        :..|.||:|..  .....|:    |.....|..|.
  Rat  1287 FLGADCSL---ACPQGRFGPSC--------AHVCACRQGAACDPVSGACICSPGKTGVRCEHGCP 1340

  Fly   594 ED---EQCKPLLASCNSEGKCGCNDEQHAKNGVCETKRE-LGESCTKA-----------TECYVE 643
            :|   :.|: |..:|.:.|.|      ||.||.|..... :|..|..|           .||:.:
  Rat  1341 QDRFGKGCE-LKCACRNGGLC------HATNGSCSCPLGWMGPHCEHACPAGRYGAACLLECFCQ 1398

  Fly   644 KDPENVECR--NSVCQCKLGYSANANQNQC 671
               .|..|.  ...|.|..|:...|.::.|
  Rat  1399 ---NNGSCEPTTGACLCGPGFYGQACEHSC 1425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7381	NP_650242.1	EB	68..112	CDD:279949	13/83 (16%)
		EB	101..155	CDD:279949	15/53 (28%)
		EB	570..624	CDD:279949	17/62 (27%)
		EB	613..665	CDD:279949	15/65 (23%)
Megf6	NP_075244.1	EMI	42..112	CDD:284877
		FXa_inhibition	127..162	CDD:291342
		vWFA	<154..202	CDD:294047
		vWFA	<237..285	CDD:294047
		vWFA	<284..325	CDD:294047
		FXa_inhibition	338..373	CDD:291342
		vWFA	<371..410	CDD:294047
		vWFA	<413..452	CDD:294047
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1555..1574
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900