DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7381 and pear1

DIOPT Version :9

Sequence 1:	NP_650242.1	Gene:	CG7381 / 41589	FlyBaseID:	FBgn0038098	Length:	712	Species:	Drosophila melanogaster
Sequence 2:	XP_700533.4	Gene:	pear1 / 571812	ZFINID:	ZDB-GENE-091230-1	Length:	1020	Species:	Danio rerio

Alignment Length:	823	Identity:	145/823 - (17%)
Similarity:	214/823 - (26%)	Gaps:	407/823 - (49%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 GVLC---------CAVLSPQGDGGV--------LAVFW--PCETE--------ADCTAD-----G 43
            |.||         ||...|..:||:        ....|  |..||        .:|:.|     |
Zfish   215 GTLCEESCPRPKRCAARCPCQNGGICQGNGVCLCPPGWMGPVCTERCPPGRFGINCSKDCLCHNG 279

  Fly    44 TSCDFASGQCECSTFDTVLAENFTQCLATSLIGEKCDDSVQCNLMPTGASCKAGVCDCADGQNYL 108
            ..||...|||:|....|               ||:|::  :|.:...|..|| ||||||:|....
Zfish   280 GHCDQEKGQCQCDAGYT---------------GERCNE--ECPVGTYGEDCK-GVCDCANGARCY 326

  Fly   109 ---------------------------------RGKCRPLNGLGESC---ETDLDCYFGYDRASV 137
                                             |..|.|||.|  ||   :.:..|..|:  |.:
Zfish   327 NIHGGCLCEPGFKGPRCDHRMCPEAVFGMHCQHRCLCNPLNTL--SCHPLKGECTCQPGW--AGL 387

  Fly   138 SCQQNVCGCANGYYNRYGNICRRKSMEENDACVVNADCDELGAGVECV-GLVCTYVDEITTTPGG 201
            .|.:.   ||.||   |||.|.       :.|:             || |.||
Zfish   388 YCNET---CAQGY---YGNGCL-------EPCL-------------CVNGGVC------------ 414

  Fly   202 ETEETETTNPGSPEDDDSTTAEAITETADPEQETAFSSRRQLTKAFVHAPP---PTHSDAAAQVS 263
                            ||.|.:.                        |.||   ..|.:...:..
Zfish   415 ----------------DSVTGQC------------------------HCPPGFTGLHCEKLCEDG 439

  Fly   264 FAQLTNGDTEPLISPRSHEIAVQTSIEKYELREVGRSVRNAATATTTTTATASTSTSSRRNSSRN 328
            |
Zfish   440 F---------------------------------------------------------------- 440

  Fly   329 QRHAHGQRRRLPALFRFDDEDIKTYSTLGSSRDDDDADEKKYGSSCTDNGKTCSGLPHSICS--K 391
                                                     ||..|.   ..|..:...:||  .
Zfish   441 -----------------------------------------YGKGCL---SACKCVNSIVCSPVD 461

  Fly   392 NICLCRQGYYARNGKCFAELGEIAESTDECEYEFDQLTKTCNCQKNYFYERDLRNCRKPIQYHLS 456
            ..|:|::|:..                .:|.....:.|....|.         |.|:
Zfish   462 GACICKEGWRG----------------PDCSIACSEGTWGPGCN---------RTCK-------- 493

  Fly   457 CTSNSQCSPFGASYCHPEIPRRCT-------CEEYALYDAIKQLCEYKRGLGAECESNDGCPVDH 514
            ||:.:.|.|...| |      :||       |:|..|.......|:.:    .:|..::||   .
Zfish   494 CTNGASCDPADGS-C------KCTAGWRGASCDEPCLIGTFGPGCQNQ----CDCVHDEGC---E 544

  Fly   515 SVCSNRVCVCADNYFEKDDQCMRGI-GADCSVEDDCIPENTECQEKDEEDQSRTCQCRKGY---- 574
            ||....:|:..........||..|. |..|:....|:...| ||.     .:.||.|:.|:
Zfish   545 SVTGQCLCLPGWTGVRCTQQCPEGTWGIQCNQTCSCLNSAT-CQA-----HTGTCLCKPGFWGAQ 603

  Fly   575 -VH------FKDECLKEAEELEDECVEDEQCK--------------PLL----------ASCNSE 608
             .|      |.::|.:..    ..||....|.              ||.          :.|::.
Zfish   604 CQHMCSAGLFGEKCSRHC----PPCVHASSCHHITGDCQCLSGYTGPLCEQACPVGRYGSHCSNV 664

  Fly   609 GKCGCNDEQHAKNGVCETKR--------------ELGESCTKATECYVEKDPENVEC--RNSVCQ 657
            .:|..|...|.:.|:|....              ..|.:|.:...|     |.|..|  .|..|.
Zfish   665 CRCTNNATCHHEVGLCICPAGWTGSDCSLLCQAGTFGINCAQTCSC-----PPNHSCDPHNGDCV 724

  Fly   658 CKLGYSANANQNQCIRVM----PNKKNSSGRPSALKIITFMLI 696
            |:.|........|.:.||    |.:::|.|..:.:.::..:::
Zfish   725 CEPGPGEACKPEQELSVMVPVSPVERDSWGAIAGIVVLVILVV 767

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7381	NP_650242.1	EB	68..112	CDD:279949	15/76 (20%)
		EB	101..155	CDD:279949	19/89 (21%)
		EB	570..624	CDD:279949	15/88 (17%)
		EB	613..665	CDD:279949	14/67 (21%)
pear1	XP_700533.4	EMI	29..96	CDD:284877
pear1	XP_700533.4	Laminin_EGF	411..451	CDD:278482	15/199 (8%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D561378at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910