DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7381 and stab1

DIOPT Version :9

Sequence 1:	NP_650242.1	Gene:	CG7381 / 41589	FlyBaseID:	FBgn0038098	Length:	712	Species:	Drosophila melanogaster
Sequence 2:	NP_001182543.1	Gene:	stab1 / 570626	ZFINID:	ZDB-GENE-050208-554	Length:	2553	Species:	Danio rerio

Alignment Length:	890	Identity:	177/890 - (19%)
Similarity:	272/890 - (30%)	Gaps:	306/890 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 PCETEADCTADGTSCDFASGQCECSTFDTVLAENFTQCLATSLIGEKCDDSVQC------NLMPT 90
            ||..:..| .||.:   .:|.|:|....|.:..:.  |......||.||:..:|      |...:
Zfish   727 PCYGKGTC-FDGIN---GNGSCKCEAAFTGVGCHL--CSNPKKHGENCDEDCRCVHGVCDNRPGS 785

  Fly    91 GASCKAG----------------VCDCADGQ----------NYLRGK----CRP-LNGLGESCET 124
            ...|:.|                ||| :||.          .|::|:    |:| ..|.|.:|..
Zfish   786 SGVCRRGSCFEGFLGELCDQTASVCD-SDGALLHCHIHAICLYVKGQTTCVCQPGYEGDGYACTE 849

  Fly   125 DLDCYF----GYDRASVSCQQNV----CGCANGYYNRYGNIC---RRKSMEENDACVVNADCDEL 178
            ...|..    |.|..:| |..|.    |.|..|:... |::|   ....:|....|..||||...
Zfish   850 SNPCLLPQRGGCDTNAV-CSYNAGKVNCVCMEGWTGD-GSLCVEINNCQLESRGGCHENADCTST 912

  Fly   179 GAGV-ECV--------GLVCTYVDEITTTPGG--ETEETETTNPGSPE---------DDDSTTAE 223
            ..|. ||.        |::|..|:...:..||  ...:.:.|:||:.|         |..|....
Zfish   913 APGQNECSCKKGYMGDGIICKIVNPCLSDNGGCHSLAKCKLTSPGTRECTCPSEFEGDGLSCYGN 977

  Fly   224 AITE--------------------------TADPEQETAFSSRRQLTKAF---VHAPPPTHSDAA 259
            .:.|                          ||....:.||.:...|.::|   .:..|  |   .
Zfish   978 MLVELDGNSEFYYFNRFLQRHKVIETDSQVTALVPSKAAFKNLSDLEESFWFDYYRLP--H---L 1037

  Fly   260 AQVSFAQ--LTNGDTEPLISPRSHEIAVQT-SIEKYELREVGRS--VRNAATATTTTTA------ 313
            .||.|.:  .|:.|.......     .||| .:.|:|::..||.  :.||........|
Zfish  1038 LQVHFLEGIYTSEDLRQKAGK-----TVQTIGMTKWEVQSNGRELMISNATILVPDIKAINGCIH 1097

  Fly   314 ---------------TASTSTSSRRNSS-----RNQRHAHGQRRRLPA-----LFRFDD------ 347
                           ...|......|:.     |.....:.....:|.     |..:|.
Zfish  1098 IIDTVLRPPLSDFPPPPPTLMKFLNNTPEFSLFRQAALLYNLENSIPTRDYTILIPYDSAVQEYL 1162

  Fly   348 ----------EDIKTYSTLGSSRDDDDADEKKYGSSCTDNGKTCS-------------------- 382
                      |.:|.:..|......:...::.:.::...||....
Zfish  1163 IKTNATQLSKEIVKYHVILSEQLFPEHLSDRLFKNTFLGNGTQIMFFVDIENQIIANDVPVNMSY 1227

  Fly   383 ---------GLPHSI------CSKNICLCRQGYYARNGKCFA----------------------- 409
                     |:|..:      |||::.|...|   |.|.|.|
Zfish  1228 IETRHGIVFGIPRVLDLHKNHCSKDVILKITG---RCGDCKAAPQCPFSAKPTQPKFPQNMKSNC 1289

  Fly   410 ----ELGEIAESTDECEYEFDQLTKTCNCQKNYFYERDLRNCRKPIQYHLSCTSNSQCSP--FGA 468
                .:|:..::...|..:..:.||..:|...|| ..|...|  |......|::|.||..  .|.
Zfish  1290 KYRTRVGKKRKTVSGCLMDCLRTTKDHSCCPGYF-GHDCGKC--PGTLDNWCSNNGQCEDGLHGT 1351

  Fly   469 SYCHPEIPRRCTCEEYALYDAIKQLCEYKRGLGAECESNDGCPVDHSVC-----SNRVCVCADNY 528
            .        :|.|.| ..:....::||..| .|.:|:|.  |..:|..|     .|..|:|...:
Zfish  1352 G--------KCLCNE-GFHGTACEMCEPGR-YGKDCKSE--CHCEHGKCLDGLEGNGQCICFKGW 1404

  Fly   529 -------FEKDDQCMRGIGADCSVEDDCIPENTECQEKDEEDQSRTCQCRKGYVHFKDECLKEAE 586
                   ...||.|    |..|.|..:||        ..:.....||.|..||......|    |
Zfish  1405 KGVKCSVVVVDDAC----GGVCDVNANCI--------SGDSGTPPTCSCTAGYKGNGTSC----E 1453

  Fly   587 ELEDECVEDEQCKPLLASCN----SEGKCGCNDEQHAKNGVCETKRELGES--CTKATECYVEKD 645
            |: :.|.||.....:.|:|.    .|..|.|            |...:|:.  |.:...|.|...
Zfish  1454 EI-NPCAEDNGGCSVNANCTKTAPGERTCTC------------TTNYIGDGVICVEMDACLVNNG 1505

  Fly   646 --PENVECRNS-----VCQCKLGYSANANQNQCIRVMPNKKNSSG 683
              .||..|..:     .|.|:.|:.:..  ::|:.|.|.:|::.|
Zfish  1506 GCDENAICMKTGPNRVACACRPGFISQG--HRCLAVNPCRKDNGG 1548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7381	NP_650242.1	EB	68..112	CDD:279949	16/79 (20%)
		EB	101..155	CDD:279949	18/76 (24%)
		EB	570..624	CDD:279949	14/57 (25%)
		EB	613..665	CDD:279949	12/60 (20%)
stab1	NP_001182543.1	EGF_3	227..257	CDD:289699
		Fasciclin	379..475	CDD:295423
		FAS1	455..630	CDD:225214
		Fasciclin	504..630	CDD:280607
		EGF_3	819..847	CDD:289699	6/27 (22%)
		EGF_3	859..889	CDD:289699	9/31 (29%)
		EGF_3	901..932	CDD:289699	9/30 (30%)
		EGF_3	938..974	CDD:289699	7/35 (20%)
		Fasciclin	1002..1103	CDD:280607	23/110 (21%)
		Fasciclin	1125..1242	CDD:295423	11/116 (9%)
		EGF_3	1458..1494	CDD:289699	10/47 (21%)
		EGF_3	1500..1536	CDD:289699	8/37 (22%)
		EGF_3	1542..1578	CDD:289699	2/7 (29%)
		Fasciclin	1611..1711	CDD:280607
		Fasciclin	1734..1864	CDD:280607
		EGF_3	2085..2120	CDD:289699
		EGF_3	2128..2163	CDD:289699
		Link_domain_TSG_6_like	2198..2290	CDD:239592
		Fasciclin	2322..2448	CDD:295423
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900