DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7381 and megf6b

DIOPT Version :9

Sequence 1:	NP_650242.1	Gene:	CG7381 / 41589	FlyBaseID:	FBgn0038098	Length:	712	Species:	Drosophila melanogaster
Sequence 2:	XP_009304569.1	Gene:	megf6b / 557764	ZFINID:	ZDB-GENE-101112-3	Length:	1589	Species:	Danio rerio

Alignment Length:	846	Identity:	166/846 - (19%)
Similarity:	235/846 - (27%)	Gaps:	337/846 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LGVLC-----------------CAVLSPQGDGGVLAVFWPCETEADC-TADGTSCDFASGQCECS 56
            |||.|                 |..:...|..|:     .||:..|| .|||. ||..:|:|.|.
Zfish   863 LGVRCNPVSGRCSCPPGWTGHNCRKVCDAGRWGL-----DCESVCDCRNADGV-CDAQTGRCHCE 921

  Fly    57 TFDTVLAENFT------QCLATSLIGEKCDDSVQCNLMPTGASCK--AGVCDCADGQNYLRGKCR 113
            .       .||      :|.|.| .|..|....||.   ..|||.  .|.|.|..|..
Zfish   922 A-------GFTGARCDQKCPAGS-FGPGCKHRCQCE---NQASCDHVGGACTCKTGWT------- 968

  Fly   114 PLNGLGESCETDLDC---YFGYDRASVSCQQNVCGCANGYYNRY------------GNICRRK-- 161
                 |..||.  .|   ::|.|     |||. |.|.||....:            |..|.:.
Zfish   969 -----GTFCEK--PCPQGFYGLD-----CQQK-CVCLNGGLCDHVSGQCFCKAGWIGTRCNQTCP 1020

  Fly   162 ------SMEENDACVVNADCDELGAGVECVGLVCTYVDEITTTPGGETEETETTNPGSPEDDDST 220
                  |..:...|..|:.||.:....||              ..|.|.:|.:....:....|..
Zfish  1021 AGWFGVSCSQTCVCHNNSSCDAVSGQCEC--------------GAGWTGDTCSQRCPAGVFGDGC 1071

  Fly   221 TAEAITE---TADPEQETAFSSRRQLTKAFVHAPPPTHSDAAAQVSFAQLTNGDTEPLISPRSHE 282
            ....:.:   :.|||....|.             |...:.||.|:.
Zfish  1072 VHRCLCQNGASCDPESGHCFC-------------PSGWTGAACQLE------------------- 1104

  Fly   283 IAVQTSIEKYELREVGRSVRNAATATTTTTATASTSTSSRRNSSRNQRHAHGQRRRLPALFRFDD 347
                                        ..|....|....|....|.....||..|......:..
Zfish  1105 ----------------------------CPAGRFGSDCQDRCECVNGAQCDGQTGRCVCPPGWTG 1141

  Fly   348 EDIKTYSTLGSSRDDDDADEKKYGSSC-----TDNGKTCSGLPHSICSKNICLCRQGYYARNGKC 407
            |           |.:::.:...:|..|     .|:|..|    |.:..:  |||..|:..|..:.
Zfish  1142 E-----------RCENECERGWFGVGCEDRCQCDHGAVC----HHVSGQ--CLCPAGWRGRRCEK 1189

  Fly   408 FAELGEIAE---------STDECEYEFDQLTKTCNCQKNYFYERDLRNCRKPIQYHLSCTSNSQC 463
            ....|...:         |...|.:    :|..|.|...:..:....:| .|..:...|....||
Zfish  1190 ACLPGSFGQDCVQRCSCPSGSSCHH----VTGHCGCAPGFTGDGCEHSC-LPGTFGQDCNQVCQC 1249

  Fly   464 SP--------FGASYCHPEIP-RRC--TCEEYALYDAIKQLCEYKRG----------------LG 501
            |.        .|..||.|... .:|  ||.:.......:..||...|                :|
Zfish  1250 SERNQLCHPVTGVCYCAPGFTGLKCEQTCPQGLYGSGCEHQCECLNGGVCLSDSGSCQCPAGFIG 1314

  Fly   502 AECESNDGCPVD---------------------------HSV---------------CSNR---- 520
            |:|  |..||..                           |.|               ||||
Zfish  1315 AQC--NQTCPAGRYGLDCAHVSACGTGVRNDPATGRCTAHQVCPPGWFGSGCSQRCDCSNRGVCD 1377

  Fly   521 ----VCVCADNYFEK--DDQCMRG-IGADCSVEDDCIPENTECQEKDEEDQSRTCQCRKGYV--- 575
                .|.||..:..|  |.:|..| .|.|||::..| ..|:.|     :..:.:|.||.||.
Zfish  1378 GVSGNCSCALGWTGKHCDKECPDGSFGPDCSLQCSC-QNNSTC-----DRVTGSCHCRPGYYGHL 1436

  Fly   576 --H------FKDECLKEAEELEDECVEDEQCKPLLASCNSEGKCGCNDEQHAK--NGVCETKREL 630
              |      |...|.::.     :|:....|.|      ..|:|.|....|..  ..||...| .
Zfish  1437 CEHACPAGLFGSGCQQQC-----DCMNGASCHP------DTGQCVCPAGVHGPRCQHVCAQGR-F 1489

  Fly   631 GESCTKATECY--VEKDP-----------ENVECRNS------------VCQCKLGYSANANQNQ 670
            |.:|:::.:|.  ...||           ..|.|.:.            :|:|:.|...::...:
Zfish  1490 GVNCSQSCDCADGASCDPVSGRCVCPSGKTGVRCDSDCSVNRFGPDCSLLCECENGAQCDSRNGR 1554

  Fly   671 C 671
            |
Zfish  1555 C 1555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7381	NP_650242.1	EB	68..112	CDD:279949	14/45 (31%)
		EB	101..155	CDD:279949	15/68 (22%)
		EB	570..624	CDD:279949	14/66 (21%)
		EB	613..665	CDD:279949	15/78 (19%)
megf6b	XP_009304569.1	EMI	33..102	CDD:284877
		FXa_inhibition	152..187	CDD:291342
		vWFA	<184..227	CDD:294047
		FXa_inhibition	234..270	CDD:291342
		FXa_inhibition	276..311	CDD:291342
		vWFA	<308..350	CDD:294047
		FXa_inhibition	363..398	CDD:291342
		vWFA	<396..436	CDD:294047
		FXa_inhibition	445..480	CDD:291342
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900