DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7381 and drpr

DIOPT Version :9

Sequence 1:	NP_650242.1	Gene:	CG7381 / 41589	FlyBaseID:	FBgn0038098	Length:	712	Species:	Drosophila melanogaster
Sequence 2:	NP_001261276.1	Gene:	drpr / 38218	FlyBaseID:	FBgn0027594	Length:	1042	Species:	Drosophila melanogaster

Alignment Length:	833	Identity:	171/833 - (20%)
Similarity:	252/833 - (30%)	Gaps:	316/833 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 CAVLSPQGDGGVLAVFWPCETEADCTADGTSCDFASGQCECSTFDTVLAENFTQCLATSLIGEKC 79
            ||.:.|:|..|.     .|..:..| .:|..|...||:|:|       |..||        |..|
  Fly   171 CADICPEGFFGA-----NCSEKCRC-ENGGKCHHVSGECQC-------APGFT--------GPLC 214

  Fly    80 DDSVQCNLMPTGASC--------------KAGVCDCADG--QNYLRGKCRPLNGLGESCETDLDC 128
            |  ::|.....||.|              :.|.|.|..|  .:....|| |:...|..|:...:|
  Fly   215 D--MRCPDGKHGAQCQQDCPCQNDGKCQPETGACMCNPGWTGDVCANKC-PVGSYGPGCQESCEC 276

  Fly   129 YFGYDRASVSCQQNVCGCANGY----------YNRYGNICRRKSMEENDACVVNAD----CDELG 179
            |.|.....::.|   |.|..||          .|.||..|.......|||....|:    |:...
  Fly   277 YKGAPCHHITGQ---CECPPGYRGERCFDECQLNTYGFNCSMTCDCANDAMCDRANGTCICNPGW 338

  Fly   180 AGVECVGLVC---TYVDEITTTPGGETEETETTNPGSPEDDDSTTAEAITETADPEQETAFSSRR 241
            .|.:|...:|   .|..:...|...:.|.|:..:|               ||.:.:....:||
  Fly   339 TGAKCAERICEANKYGLDCNRTCECDMEHTDLCHP---------------ETGNCQCSIGWSS-- 386

  Fly   242 QLTKAFVHAPPPTHSDAAAQVSFAQLTNGDTEPLISPRSHEIAVQTSIEKYELREVGRSVRNAAT 306
                                   ||.|...|.....|..               |:..:.:|.|.
  Fly   387 -----------------------AQCTRPCTFLRYGPNC---------------ELTCNCKNGAK 413

  Fly   307 ATTTTTATASTSTSSRRNSSRNQRHAHGQRRRLPALFRFDDEDIKTYSTLGSSRDDDDADEKKYG 371
            .:........               |.|.|                     ....::..:...:|
  Fly   414 CSPVNGTCLC---------------APGWR---------------------GPTCEESCEPGTFG 442

  Fly   372 SSCT-----DNGKTCSGLPHSICSKNICLCRQGYYARNGKCFAELGEIAESTDECEYEFDQLTKT 431
            ..|.     .||..|.  |.:    ..|||..|:  :|.||                  |:
  Fly   443 QDCALRCDCQNGAKCE--PET----GQCLCTAGW--KNIKC------------------DR---- 477

  Fly   432 CNCQKNYFYERDLRNCRKPIQYHLSCTSNSQCSP------FGASYCHPEIPRRCTCEEYALYDAI 490
             .|..|:|.:...:.|        .|.:|:.|:|      ..|.:......|:|...::....|.
  Fly   478 -PCDLNHFGQDCAKVC--------DCHNNAACNPQNGSCTCAAGWTGERCERKCDTGKFGHDCAQ 533

  Fly   491 KQLCEYKRGL----------------GAECESN-------DGCPVDHSVCSNRVCVCADNYFEKD 532
            |..|::...|                |..||:|       :.|        ::||.|.:|.....
  Fly   534 KCQCDFNNSLACDATNGRCVCKQDWGGVHCETNCRSGYYGENC--------DKVCRCLNNSSCDP 590

  Fly   533 DQ----CMRG-IGADCSVEDDCIP--ENTECQEKDEE--DQSRTCQ-------CRKGYVHFKDE- 580
            |.    |..| .||||:  :.|.|  ...||:|:..|  ..:::|.       ||.||:....|
  Fly   591 DSGNCICSAGWTGADCA--EPCPPGFYGMECKERCPEILHGNKSCDHITGEILCRTGYIGLTCEH 653

  Fly   581 ----------C-LK-------EAEELEDECVEDEQCKPLLASCNSEGKC-------GCNDE---Q 617
                      | ||       |...:..:|    ||.|.....|....|       ||...   .
  Fly   654 PCPAGLYGPGCKLKCNCEHGGECNHVTGQC----QCLPGWTGSNCNESCPTDTYGQGCAQRCRCV 714

  Fly   618 HAK-----NG--VCET------------KRELGESCTKATECYVEKDPENVECRNS-VCQCKLGY 662
            |.|     :|  :|||            :...||.|.....|    ...|.:|..: .|.|:.||
  Fly   715 HHKVCRKADGMCICETGWSGTRCDEVCPEGFYGEHCMNTCAC----PSANFQCHAAHGCVCRSGY 775

  Fly   663 SANANQNQCI---RVMPNKKNSSGRPSALKIITFMLIGSAFLITSAAIKQAYY 712
            :.: |.::.|   |:....:|||....||.::...|.  |.:|.:..|   ||
  Fly   776 TGD-NCDELIASQRIADQSENSSRASVALTLVLMTLF--ACIIFAVFI---YY 822

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7381	NP_650242.1	EB	68..112	CDD:279949	11/59 (19%)
		EB	101..155	CDD:279949	16/65 (25%)
		EB	570..624	CDD:279949	20/89 (22%)
		EB	613..665	CDD:279949	17/74 (23%)
drpr	NP_001261276.1	EMI	27..92	CDD:284877
		EGF_CA	274..319	CDD:304395	12/47 (26%)
		DSL	<479..518	CDD:302925	9/46 (20%)
		DSL	<567..606	CDD:302925	10/46 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D561378at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.910