DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7381 and Pear1

DIOPT Version :9

Sequence 1:	NP_650242.1	Gene:	CG7381 / 41589	FlyBaseID:	FBgn0038098	Length:	712	Species:	Drosophila melanogaster
Sequence 2:	NP_001128431.1	Gene:	Pear1 / 295293	RGDID:	1305653	Length:	1033	Species:	Rattus norvegicus

Alignment Length:	732	Identity:	148/732 - (20%)
Similarity:	223/732 - (30%)	Gaps:	262/732 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LGVLCCAVLSPQGDGGVLAVFWP-CETEADCTADGTSCDFASGQCECSTFDTVLAENFTQCLATS 73
            :||: |::..|:|..|      | |..|..| .:|..||..:|||.|               |..
  Rat   253 MGVI-CSLPCPEGFHG------PNCTQECRC-HNGGLCDRFTGQCHC---------------APG 294

  Fly    74 LIGEKCDDSVQCNLMPTGASCKAGVCDCADGQNYLRGKCRPLNGLGESCETDLDCYFGY--DRAS 136
            .||::|.:  :|.:...|..| |..||||.|     .:|.|.||   :|.    |..|:  ||
  Rat   295 YIGDRCRE--ECPVGRFGQDC-AETCDCAPG-----ARCFPANG---ACL----CEHGFTGDR-- 342

  Fly   137 VSCQQNVCGCANGYYNRYGNICRRKSMEENDACVVNAD----CDELGAGVEC----VGLVCTYVD 193
              |.:.:  |.:|   |||..|:       |.|..:.:    |..:.....|    .||.|
  Rat   343 --CTERL--CPDG---RYGLSCQ-------DPCTCDPEHSLSCHPMHGECSCQPGWAGLHC---- 389

  Fly   194 EITTTPGGETEETETTNPGSPEDDDSTTAEAITETADPEQETAFSSRRQLTKAFVHAPPPTHSDA 258
                            |...|:|         |..|..::..          ..:|.     ...
  Rat   390 ----------------NESCPQD---------THGAGCQEHC----------LCLHG-----GVC 414

  Fly   259 AAQVSFAQLTNGDTEP----LISPRSHEIAVQTSIEKYELREVGRSVRNAATATTTTTATASTST 319
            .|.....:...|.|.|    |..|.::.|...:..          |..||...:...........
  Rat   415 LADSGLCRCAPGYTGPHCANLCPPNTYGINCSSHC----------SCENAIACSPVDGTCICKEG 469

  Fly   320 SSRRNSSRNQRHAHGQRRRLPALFRFDDEDIKTYSTLGSSRDDDDADEKKYGSSCTDNGKTCSGL 384
            ..|.|.|            :|                        .....:|.||   ..:|...
  Rat   470 WQRGNCS------------VP------------------------CPPGTWGFSC---NASCQCA 495

  Fly   385 PHSICS--KNICLCRQGYYARNGKC-----FAELGEIAESTDECEYE--FDQLTKTCNCQKNYFY 440
            ...:||  ...|.|..|:  |...|     ..:.||...|..:|::.  .|.:...|.||..:..
  Rat   496 HEGVCSPQTGACTCTPGW--RGVHCQLPCPKGQFGEGCASVCDCDHSDGCDPVHGHCRCQAGWMG 558

  Fly   441 ERDLRNCRKPIQ---YHLSCTSNSQCSPFGASYCHPEIPRRCTCEEYALYDAIKQLC---EY-KR 498
            .|    |..|..   :..:|::...|...|.  |.|| ...|.|.......:.::.|   .| ||
  Rat   559 TR----CHLPCPEGFWGANCSNACTCKNGGT--CVPE-NGNCVCAPGFRGPSCQRPCPPGRYGKR 616

  Fly   499 GLGAECESNDGCPVDHSVCSNRVCVCADNYFEKDDQCMRG-IGADCSVEDDCIPEN--TECQEKD 560
            .:..:|.::..|......||                |:.| .|.|||  :.|.|.:  .:|
  Rat   617 CVPCKCNNHSSCHPSDGTCS----------------CLAGWTGPDCS--ESCPPGHWGLKC---- 659

  Fly   561 EEDQSRTCQCRKGYVHFKDECLKEAEELEDECVEDEQCKPLLASCN-SEGKCGCNDEQHAKNGVC 624
                |:.|||..|                             |:|: .:|.|.|...:...|  |
  Rat   660 ----SQPCQCHHG-----------------------------ATCHPQDGSCVCIPGRTGPN--C 689

  Fly   625 E---TKRELGESCTKATECYVEKDP-ENVECRNSVCQCKLGYS---ANANQNQCIRVMPNK---K 679
            .   ..|..|.:|::..:|    || |........|.|..|:|   ......:...:||..   .
  Rat   690 SEGCPSRMFGVNCSQLCQC----DPGEMCHPETGACVCPPGHSGAHCKVGSQESFTIMPTSPVIH 750

  Fly   680 NSSGRPSALKIITFMLI 696
            ||.|....:.::..:::
  Rat   751 NSLGAVIGIAVLGTLVV 767

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7381	NP_650242.1	EB	68..112	CDD:279949	13/43 (30%)
		EB	101..155	CDD:279949	16/55 (29%)
		EB	570..624	CDD:279949	8/54 (15%)
		EB	613..665	CDD:279949	14/58 (24%)
Pear1	NP_001128431.1	EMI	25..93	CDD:284877
		EGF_CA	535..580	CDD:304395	9/48 (19%)
		Laminin_EGF	620..665	CDD:278482	15/70 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D561378at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910