DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7381 and MEGF6

DIOPT Version :9

Sequence 1:	NP_650242.1	Gene:	CG7381 / 41589	FlyBaseID:	FBgn0038098	Length:	712	Species:	Drosophila melanogaster
Sequence 2:	XP_011539187.1	Gene:	MEGF6 / 1953	HGNCID:	3232	Length:	1603	Species:	Homo sapiens

Alignment Length:	835	Identity:	165/835 - (19%)
Similarity:	236/835 - (28%)	Gaps:	358/835 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 CETEAD-CTADGTSCDF------ASGQCEC-------STFDTVLAENFT---------QCLATSL 74
            |:.:.| |......|..      .|..|||       :...|.||.|..         .|:..::
Human   220 CQYDVDECRTHNGGCQHRCVNTPGSYLCECKPGFRLHTDSRTCLAINSCALGNGGCQHHCVQLTI 284

  Fly    75 IGEKCDDSVQC----NLMPTGASCKAGVCDCADGQNYLRGKCRPLNGLGESCETDLDCYFGYDRA 135
            ...:|    ||    .|...|..| .....||:.......:|:.:.||.. ||    |:.||..|
Human   285 TRHRC----QCRPGFQLQEDGRHC-VRRSPCANRNGSCMHRCQVVRGLAR-CE----CHVGYQLA 339

  Fly   136 S--------VSCQQNVCGCANGYYNRYGNI----------------CRRKSMEENDACVVN---- 172
            :        ..|...:..||:|..|..|:.                |.|..||..::|..|
Human   340 ADGKACEDVDECAAGLAQCAHGCLNTQGSFKCVCHAGYELGADGRQCYRIEMEIVNSCEANNGGC 404

  Fly   173 -ADCDELGAGVECV----------GLVCTYVDEITTTPGGETEETETTNPGSPE---------DD 217
             ..|....||..|.          ...|..||:...:|.  .::..|.|||..|         ..
Human   405 SHGCSHTSAGPLCTCPRGYELDTDQRTCIDVDDCADSPC--CQQVCTNNPGGYECGCYAGYRLSA 467

  Fly   218 DSTTAEAITETADPEQETAFSSR-------RQLTKAF---VHAPPPTHSDAAAQVSFAQ-LTNGD 271
            |....|.:.|.|        |||       ..|..:|   ..|....|.|........: :.:.|
Human   468 DGCGCEDVDECA--------SSRGGCEHHCTNLAGSFQCSCEAGYRLHEDRRGCSPLEEPMVDLD 524

  Fly   272 TE-PLISPRSHEIAVQTSIEKYELREVGRSVRNAATATTTTTATASTSTSSRRNSSRNQRHAHGQ 335
            .| |.:.|..|...:|.
Human   525 GELPFVRPLPHIAVLQD------------------------------------------------ 541

  Fly   336 RRRLPALFRFDDEDIKTYSTLGSSRDDDDADEKKYGSSCTDNGKTCSGLPHSICSKNICL----- 395
              .||.||:.||        :|:  |:::|:.:         |:      |::..|.:||
Human   542 --ELPQLFQDDD--------VGA--DEEEAELR---------GE------HTLTEKFVCLDDSFG 579

  Fly   396 ---------CRQGYYARNGKCFAELGEIAESTDECEYEFDQLTKTCNCQKNYFYERDLRNCRKPI 451
                     ||.|     |.|...|                  ..|:|.:.:
Human   580 HDCSLTCDDCRNG-----GTCLLGL------------------DGCDCPEGW------------- 608

  Fly   452 QYHLSCTSNSQCSP--FGASYCHPEIPRRCTCEEYALYDAIKQLCEYKRGL-GAECESNDGCPVD 513
             ..|.|  |..|.|  ||.:...     .|:|:.....|::...|....|: |..||  ||||..
Human   609 -TGLIC--NETCPPDTFGKNCSF-----SCSCQNGGTCDSVTGACRCPPGVSGTNCE--DGCPKG 663

  Fly   514 H--------SVCSNR--------VCVCADNYFEKDDQCMRG-----------IGADCSVEDDCI- 550
            :        ..|:||        .|:|        |..:.|           .|..||.|..|:
Human   664 YYGKHCRKKCNCANRGRCHRLYGACLC--------DPGLYGRFCHLTCPPWAFGPGCSEECQCVQ 720

  Fly   551 PENTECQEKDEEDQSRTCQCRKGYVHFKDE-CLKEAE--ELEDECVEDEQCKPLLASCNS-EGKC 611
            |....|.::|     .:|.|:.|   |:.| |..|.|  .....|.:...| |:..:|:| .|:|
Human   721 PHTQSCDKRD-----GSCSCKAG---FRGERCQAECELGYFGPGCWQACTC-PVGVACDSVSGEC 776

  Fly   612 G-----------CNDE--------------------QHAKNGVCETK------------------ 627
            |           |..|                    .|...|.|...
Human   777 GKRCPAGFQGEDCGQECPVGTFGVNCSSSCSCGGAPCHGVTGQCRCPPGRTGEDCEADCPEGRWG 841

  Fly   628 ---RELGESCTKATECYVEKDPENVECR------NSVCQ--CKLGYSANANQNQC 671
               :|:..:|..|..|    |||...|.      .|.||  |..|:...:.|.:|
Human   842 LGCQEICPACQHAARC----DPETGACLCLPGFVGSRCQDVCPAGWYGPSCQTRC 892

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7381	NP_650242.1	EB	68..112	CDD:279949	9/47 (19%)
		EB	101..155	CDD:279949	16/61 (26%)
		EB	570..624	CDD:279949	19/88 (22%)
		EB	613..665	CDD:279949	18/100 (18%)
MEGF6	XP_011539187.1	EMI	108..176	CDD:284877
		vWFA	<215..261	CDD:294047	8/40 (20%)
		FXa_inhibition	268..304	CDD:291342	6/39 (15%)
		vWFA	<342..384	CDD:294047	6/41 (15%)
		FXa_inhibition	397..432	CDD:291342	6/34 (18%)
		vWFA	<432..469	CDD:294047	9/38 (24%)
		vWFA	<472..511	CDD:294047	11/46 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900