DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG7381 and F48E3.8

DIOPT Version :9

Sequence 1:	NP_650242.1	Gene:	CG7381 / 41589	FlyBaseID:	FBgn0038098	Length:	712	Species:	Drosophila melanogaster
Sequence 2:	NP_001360756.1	Gene:	F48E3.8 / 181010	WormBaseID:	WBGene00018607	Length:	2111	Species:	Caenorhabditis elegans

Alignment Length:	928	Identity:	203/928 - (21%)
Similarity:	285/928 - (30%)	Gaps:	362/928 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LTLGVLCCA--------VLSPQG-----DGGVLAVFW----PCETEADCTA--DGTSCDFASGQC 53
            |..|..|.|        |..|.|     :.||.....    ||:....|:|  .|..|  ...:|
Worm    79 LNTGTTCIASSTAIQTSVACPAGQTYIREAGVCMTVQQPGEPCQYSQQCSALEPGAYC--LKMRC 141

  Fly    54 EC------STFDTVLAENFTQC-----LATSLIGE----------KCDDSVQCNLMPTGASCKAG 97
            ||      |:.......|  .|     :..|.|||          .|..::||:.....|:|...
Worm   142 ECVYGMKKSSNGCTFVNN--DCKERGHIFISEIGECREVFPPGGKGCSHNLQCSGAYPDATCFMQ 204

  Fly    98 VCDC-------ADG---------QNY--LRGKCRPLNGLGESCETDLDCYFGYDRASVSCQQNVC 144
            .|.|       |||         |.|  :.|:|.|....|:.|.....|...:  ..:.|.:|.|
Worm   205 TCTCPPNLPVAADGTCGRSCPNNQVYSGVTGECLPEKQPGQDCIYSSQCQASF--GGLVCDKNTC 267

  Fly   145 GCANGY-------------YNRY--GNICRR--------------KSMEENDACVVNADCDELGA 180
            .|.||.             :.|.  ..||..              |.:.....||.||.|:   .
Worm   268 RCPNGLVFDGLKCSHGCPPHKRVIDKEICVEGCPSGIVEVAGRCVKQVSIGQPCVANAQCN---F 329

  Fly   181 GVECVGLVCTYVDEITTTPGGETEETETTNPGSPEDDDSTTAEAITETADPEQETAFSSRRQLTK 245
            |..|....|                  ...||....|:...|      .:.|...:..:..:.||
Worm   330 GSFCQSGTC------------------QCPPGFYVQDEQCQA------IESEPNESCQNNEKCTK 370

  Fly   246 AFVHAPPPTHSDAAAQVSFAQLTNGDTEPLISPRSHEIAVQTSIEKYELREVGRSVRNAATATTT 310
            ..|                  ..||...   .||:||:.            .|...:|.|.|...
Worm   371 GSV------------------CYNGKCS---CPRNHELI------------NGHCQQNRAAAHAY 402

  Fly   311 TTATAS--------TSTSSRRNSSRNQRHAHGQRRRLPALFRFDDEDIKTYSTLGSSRDDDDADE 367
            .||..:        .|.|..||||             |.|     .|:           ::|.|.
Worm   403 NTALENIRKIRLRFASQSKSRNSS-------------PQL-----TDV-----------ENDNDT 438

  Fly   368 KKYGSSCTDNGKTCSGLPHSICSKNICLCRQGYYARNGKCF----AELGEIAESTDEC-EYEF-D 426
            ...||:|...|.||.|  .|:|...||:|..|...|||.|.    |..|...::.:|| ::.: .
Worm   439 VPIGSACVRIGVTCDG--GSVCVAGICVCPLGKTPRNGVCIEHVAARPGTSCQNEEECVDHSYCS 501

  Fly   427 QLTKTCNCQKNYFYERDL---RNCRKPIQYHLS--------CTSNSQC----------------- 463
            ..|..|.|.|    ...:   ..||:.::.|..        |..||.|
Worm   502 PETNKCECMK----ASQMVIGGECRERLKAHPGYGCTMGEMCVGNSVCVNGKCACVDGKVEINKI 562

  Fly   464 -------SP----------FGASYCH-------------------------------PEIPRRCT 480
                   .|          .|.|||:                               .:|..|||
Worm   563 CIDQVSAKPGDTCGKGIICEGGSYCNTDSGKCACRRGENSINGICKGFTFVYPGDLCTDITSRCT 627

  Fly   481 ---------CEEYALYDAIKQLCEYKR--GLGAECESNDGCPVDHSVCSNRVCVCADNYFEKDDQ 534
                     ||......||.:.|.:::  ..|..|.....|. ..|||.|.||.|.:|...:|..
Worm   628 GGSYCARGRCECPPRMSAIDKKCVHQQTAAPGEPCSEKVACS-PFSVCENNVCKCVNNMMIRDKM 691

  Fly   535 CMR----GIGADCSVEDDCIPENTECQEKDEEDQSRTCQCRKGYVHFKDEC----------LKEA 585
            |::    .||..|:.||.|: .|:.|.:.:       |||..|:|...|.|          |...
Worm   692 CVQRRKVNIGNSCNNEDQCL-GNSTCMDNN-------CQCGIGFVASMDVCVLRKTVTPGYLCNP 748

  Fly   586 EEL---EDECVEDE-QCKP------------------------------LLASCNSEGKCGCNDE 616
            |::   :..|::.. ||:|                              |:  |.:.|||.|.:.
Worm   749 EDICTGQSVCIKGVCQCQPDYKQMHNICVKKNIGIEGSPCSSRDDCGEGLM--CGASGKCSCPEG 811

  Fly   617 QHAKNGVCETKRELGESCTKATECYVEKDPENVECRNSVCQCKLGYSANANQNQCIR--VMPNKK 679
            ..:.||.|.:..:||::||....| .|:   |.:|:.:.|.|:.||: |.| .||..  |.|
Worm   812 LFSVNGKCRSYVQLGQTCTSDDRC-AER---NAQCQENYCTCRTGYT-NIN-GQCAANIVTP--- 867

  Fly   680 NSSGRPSALKIITFMLIG 697
               ..|..|..:...|:|
Worm   868 ---AEPETLSQVKSGLLG 882

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7381	NP_650242.1	EB	68..112	CDD:279949	18/76 (24%)
		EB	101..155	CDD:279949	19/86 (22%)
		EB	570..624	CDD:279949	19/97 (20%)
		EB	613..665	CDD:279949	16/51 (31%)
F48E3.8	NP_001360756.1	EB	98..154	CDD:366756	14/57 (25%)
		EB	224..280	CDD:366756	14/57 (25%)
		EB	300..351	CDD:366756	12/71 (17%)
		EB	340..392	CDD:366756	15/90 (17%)
		EB	<438..476	CDD:366756	16/39 (41%)
		EB	514..563	CDD:366756	7/48 (15%)
		EB	552..607	CDD:366756	5/54 (9%)
		EB	596..650	CDD:366756	8/53 (15%)
		EB	639..692	CDD:366756	15/53 (28%)
		EB	681..734	CDD:366756	18/60 (30%)
		EB	723..776	CDD:366756	11/52 (21%)
		EB	808..860	CDD:366756	18/57 (32%)
		EB	961..1019	CDD:366756
		EB	<1111..1150	CDD:366756
		EB	1283..1340	CDD:366756
		EB	1413..1473	CDD:366756
		EB	1462..1517	CDD:366756
		EB	1757..1812	CDD:366756
		EB	<1893..1930	CDD:366756
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		oto18781
orthoMCL	1	0.900	-	-		OOG6_112267
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810