DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7381 and lgx-1

DIOPT Version :9

Sequence 1:	NP_650242.1	Gene:	CG7381 / 41589	FlyBaseID:	FBgn0038098	Length:	712	Species:	Drosophila melanogaster
Sequence 2:	NP_001360720.1	Gene:	lgx-1 / 180825	WormBaseID:	WBGene00002983	Length:	1754	Species:	Caenorhabditis elegans

Alignment Length:	691	Identity:	143/691 - (20%)
Similarity:	219/691 - (31%)	Gaps:	196/691 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 DSVQCNLMPTGASCKAGVCDCADGQNYLRGKCRPLNGLGESCETDLDCYFGYDRASVSCQQNV-- 143
            :|::.|.|..|.|.:|||                    |..|..:.||..|     ..|..|.
Worm   521 NSIKINQMKIGGSKQAGV--------------------GVRCSLNTDCMIG-----AYCNGNTNP 560

  Fly   144 --CGCANGYYNRYGNICRRKSMEENDACVVNADCDELGAGVECVGLVCT------YVDE------ 194
              |.|.:.:.|..|. |.:........|..:..|....:|..|:..:|.      .||:
Worm   561 PSCQCLSTHVNIEGR-CEKVIYPGQVGCRSDLQCHAAHSGTHCIDRICVCPEGQRAVDQTCVSAS 624

  Fly   195 --ITTTPGGETEETETTNPGSP--------EDDDSTTAEAITETADPEQETAFSSRRQLTKA--- 246
              :|:.|||..........||.        .|........|...:.|  :.....|..:.:.
Worm   625 EPVTSPPGGSCSNLRECTGGSVCREGWCICPDPSMIVNRGICIQSGP--KPTLPPRTPIPQVPLP 687

  Fly   247 -----FVHAPPPTHSDAAAQVSFAQLTNGDTEPLISPRSHEIAV-------------QTSIEKYE 293
                 .||.|         ||:..:.....||..::|:..:|..             ...||.:.
Worm   688 PQLPISVHVP---------QVTITKAQPFITEAPLAPQGKKIVPGGRCGPIDVCVGGSNCIEGFC 743

  Fly   294 LREVGRSVRNAA--------------TATTTTTATASTSTSSRRNSSRNQRHAHG--QRRRLPAL 342
            |...|:...|:.              .:||||..|.:|:|:....:|........  ..||.||.
Worm   744 LCPAGQQPSNSGRCEKFTTTSRQTTLPSTTTTQGTTTTTTAPPPTTSVFSFTIADLLSTRRQPAF 808

  Fly   343 FRFDDEDIKTYSTLGSSRDDDDADEKKYGSSCTDNGKTCSGLPHSICSKNICLCRQGYYARNGKC 407
            .     :|.|:..|.::....| ||      ||..|..|.|  :::|....|.|.:.|...:..|
Worm   809 I-----EIPTHVPLTTTAIQTD-DE------CTAIGLICKG--NTVCRNKSCQCPETYVLHHDGC 859

  Fly   408 FA-ELGEIAESTDECEYEFDQLTKTCNCQKNYFYERDLRNCRKPIQYHLSCTSNSQCSPFGASYC 471
            .: |.....::..:..:|                ....|...||.:   |||....|  .|.|.|
Worm   860 VSPEEAARRKARGKARHE----------------ATTARLYSKPGE---SCTQGQTC--VGGSAC 903

  Fly   472 HPEIPRRCTCEEYALYDAIKQ-LCEYKRGL----GAECESNDGCPVDHSVCSNRVCVCADNYFEK 531
              ...:.|.|.:..  ..|.| .|...|.|    ||.|.:|..| ...|.|.:.:|.|...|...
Worm   904 --SFRKLCECPQDK--SEISQGQCVTPRKLEVVPGASCNANTVC-TKGSTCESGLCRCQPGYIAV 963

  Fly   532 DDQC----------MRGIGADCSVEDDCIPENTE-CQEKDEED-QSRTCQCRKGYVHFKDECL-- 582
            ...|          ||.|....   :.|  ||.| |:.....| .:..|.|..|.:.|..:|:
Worm   964 SGNCVALPMSTTPKMRVIAKPL---ESC--ENGETCEGGSNCDYDTGICMCPPGQIVFNVQCMPP 1023

  Fly   583 --------------KEAEELEDECVEDEQCKPLLASCNS-----EGKCGCNDEQHAKNGVCETKR 628
                          |.|..:..:.:....|: :.|:|..     .|||.|.......:|.||...
Worm  1024 PTQPQITTRVTTPVKAAPVVTPKPIHSTDCE-IDANCGENKICVSGKCKCKPGFVDNSGTCEPLE 1087

  Fly   629 EL-------GESCTKATECYVEKDPENVECRNSVCQCKLGY 662
            .:       |::|.:    |.:|.....:|.:.:|:|..|:
Worm  1088 GIRGRSLRYGQACDR----YQDKCINGAKCIDKICKCAPGF 1124

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7381	NP_650242.1	EB	68..112	CDD:279949	8/30 (27%)
		EB	101..155	CDD:279949	10/57 (18%)
		EB	570..624	CDD:279949	14/74 (19%)
		EB	613..665	CDD:279949	12/57 (21%)
lgx-1	NP_001360720.1	EB	322..382	CDD:366756
		PHA02682	<388..>493	CDD:177464
		EB	565..620	CDD:366756	11/55 (20%)
		EB	609..666	CDD:366756	9/56 (16%)
		EB	<718..757	CDD:366756	6/38 (16%)
		EB	911..967	CDD:366756	16/58 (28%)
		EB	956..1020	CDD:366756	16/68 (24%)
		EB	1009..1083	CDD:366756	14/74 (19%)
		EB	1072..1124	CDD:366756	11/55 (20%)
		EB	<1215..1253	CDD:366756
		EB	1242..1301	CDD:366756
		EB	1290..1346	CDD:366756
		CE4_CDA_like_1	1409..1684	CDD:200596
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910